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Mashup Score: 2
Currently, numerous studies focus on employing fMRI-based deep neural networks to diagnose neurological disorders such as Alzheimer’s Disease (AD), yet only a handful have provided results regarding explainability. We address this gap by applying several prevalent explainability methods such as gradient-weighted class activation mapping (Grad-CAM) to an fMRI-based 3D-VGG16 network for AD diagnosis to improve the model’s explainability. The aim is to explore the specific Region of Interest (ROI) of brain the model primarily focuses on when making predictions, as well as whether there are differences in these ROIs between AD and normal controls (NCs). First, we utilized multiple resting-state functional activity maps including ALFF, fALFF, ReHo, and VMHC to reduce the complexity of fMRI data, which differed from many studies that utilized raw fMRI data. Compared to methods utilizing raw fMRI data, this manual feature extraction approach may potentially alleviate the model’s burden. Subse
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Mashup Score: 27
INTRODUCTION Alzheimer’s disease (AD) pathology is defined by β-amyloid (Aβ) plaques and neurofibrillary tau, but Lewy bodies (LBs; 𝛼-synuclein aggregates) are a common co-pathology for which effect…
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Mashup Score: 82The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology - 11 day(s) ago
Nature Reviews Neurology – In this Perspective, the authors propose a new classification system for amyotrophic lateral sclerosis and related neurodegenerative disorders that recognizes, in…
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Mashup Score: 9
Nature Reviews Neurology – Gliomas are the most common malignant primary brain tumours in adults, and they frequently contain mutations in the isocitrate dehydrogenase 1 (IDH1) or IDH2 gene….
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Mashup Score: 80Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms - 15 day(s) ago
Nature Reviews Neurology – Nociplastic pain arises from altered nociception despite the absence of tissue damage. In this Review, the authors summarize the risk factors and clinical presentation of…
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Mashup Score: 29Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results - 17 day(s) ago
Nature Medicine – Interim results from the low-dose cohort of the PROCLAIM trial show that AAV-based delivery of the progranulin gene in patients with frontotemporal dementia was safe and was…
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Mashup Score: 12CAR T cells offer hope in glioblastoma - 17 day(s) ago
Nature Reviews Neurology – Novel CAR T cells delivered directly to the CNS could have therapeutic effects in recurrent glioblastoma, according to two early-stage trials.
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Mashup Score: 6Blood test for early Parkinson disease diagnosis - 17 day(s) ago
Nature Reviews Neurology – Blood test for early Parkinson disease diagnosis
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Mashup Score: 14Genetic protection against Alzheimer disease - 17 day(s) ago
Nature Reviews Neurology – Genetic protection against Alzheimer disease
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Mashup Score: 5Infant microbiome predicts neurodevelopmental disorders - 17 day(s) ago
Nature Reviews Neurology – Infant microbiome predicts neurodevelopmental disorders
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Explainability of three-dimensional convolutional neural networks for functional magnetic resonance imaging of Alzheimer’s disease classification based on gradient-weighted class activation mapping https://t.co/brhNELMdkq