-
Mashup Score: 19Extrachromosomal DNA in cancer - 2 month(s) ago
Nature Reviews Cancer – Extrachromosomal DNA (ecDNA) is now accepted as a major contributor to cancer pathogenesis. In this Review, Yan, Mischel and Chang highlight the recent advancements in ecDNA…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 16AACR Elections - 3 month(s) ago
The voting deadline for the AACR Election is February 27.
Source: www.aacr.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 6Predicting Response in TIME and Space: Neoadjuvant Chemoimmunotherapy in Muscle-invasive Bladder Cancer - 5 month(s) ago
Author links open overlay panel Priyanka Yolmo a b, D. Robert Siemens a b c, Madhuri Koti a b c There are more references available in the full text version of this
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 2
Genomic stratification may help improve the management of patients with metastatic urothelial cancer (mUC), given the recent identification of targeta…
Source: www.sciencedirect.comCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 0Antibody-drug conjugates for urothelial carcinoma - 7 month(s) ago
The standard of care for advanced urothelial carcinoma includes platinum chemotherapy and immunotherapy. Antibody-drug conjugates (ADCs), originally d…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 30
Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to five years. Using NIH data for the period 2006-2022, we report that ~230 K99 awards were made every year, representing ~$25 million annually. About 40% of K99 awardees were women and ~89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet
Source: www.biorxiv.orgCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 41The complete sequence of a human Y chromosome - 9 month(s) ago
Nature – We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 1A viral ADP-ribosyltransferase attaches RNA chains to host proteins - 9 month(s) ago
Nature – Bacteriophage T4 uses an enzyme known as ADP-ribosyltransferase ModB to modify the translational apparatus of bacteria it infects, not only by ADP-ribosylating proteins, but also by…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 39Genome-wide prediction of disease variant effects with a deep protein language model - 9 month(s) ago
Nature Genetics – A modified framework leveraging a protein language model (ESM1b) is used to predict all possible 450 million missense variant effects in the human genome and shows potential for…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 10Topography of mutational signatures in human cancer - 9 month(s) ago
Comprehensive topography analysis of mutational signatures encompassing 82,890,857 somatic mutations in 5,120 whole-genome-sequenced tumors across 40 cancer types. Otlu et al. provide an online resource, through the COSMIC signatures database, that allows researchers to explore the interactions between somatic mutational processes and genome architecture within and across cancer types.
Source: www.cell.comCategories: Hem/Oncs, Latest HeadlinesTweet
RT @anton_gh: Beautiful review article on ecDNA in @NatureRevCancer by @HowardYChang @mischellab !! 🔥🔥👇🏻👇🏻 https://t.co/TXPMSXrpMM