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Mashup Score: 39Genome-wide prediction of disease variant effects with a deep protein language model - 10 month(s) ago
Nature Genetics – A modified framework leveraging a protein language model (ESM1b) is used to predict all possible 450 million missense variant effects in the human genome and shows potential for…
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 10Topography of mutational signatures in human cancer - 10 month(s) ago
Comprehensive topography analysis of mutational signatures encompassing 82,890,857 somatic mutations in 5,120 whole-genome-sequenced tumors across 40 cancer types. Otlu et al. provide an online resource, through the COSMIC signatures database, that allows researchers to explore the interactions between somatic mutational processes and genome architecture within and across cancer types.
Source: www.cell.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Bartomeu_Colom: 'Topography of mutational signatures in human cancer' https://t.co/UozFuL7ZQc https://t.co/UEYINwHGgw
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Mashup Score: 3
CheckMate -901 is the first and only Phase 3 trial with an immunotherapy-based combination to demonstrate a survival benefit compared to standard-of-care cisplatin-based combinations in the first-line treatment of this patient population Bristol Myers Squibb (NYSE: BMY) today announced that the sub-study of the Phase 3 CheckMate -901 trial met the dual primary endpoints of overall survival (OS)…
Source: investors.bms.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Nivolumab in Combination with Cisplatin-Based Chemotherapy Shows Overall Survival and Progression-Free Survival Benefit for Cisplatin-Eligible Patients with Unresectable or Metastatic Urothelial Carcinoma in the Phase 3 CheckMate -901 Trial https://t.co/QULmdn3MAe
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Mashup Score: 4
We uncover the mechanism underlying the restriction point phenomenon, suggest a role for cyclin-dependent kinase 4 and 6 activity in S and G2 phases, and explain the behaviour of cells following loss of mitogen signalling.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
“small molecule CDK4/6 is may be effective in phases of the cell cycle beyond G1 phase, particularly if combined with traditional chemotherapies that extend the mitosis clock by inducing DNA damage and triggering cell cycle checkpoints” https://t.co/9WNZSmcfBm
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Mashup Score: 1
Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Therapy-induced APOBEC3A drives evolution of persistent cancer cells | Nature https://t.co/6m9ltLJD2y
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Mashup Score: 4Barbara McClintock: Free to discover | Cold Spring Harbor Laboratory - 11 month(s) ago
Barbara McClintock missed an important call on the morning of October 10, 1983. She had chosen “to be free” of the interruptions that came with owning a telephone, and so it was her students and colleagues who told her that she had received the Nobel Prize for Physiology or Medicine. “That’s nice,” she said with…
Source: Cold Spring Harbor LaboratoryCategories: Hem/Oncs, Latest HeadlinesTweet-
https://t.co/YEY68sT9sr
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Mashup Score: 2Bladder cancer - Nature - 12 month(s) ago
Nature – Bladder cancer
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Congratulations @Dan_Theodorescu @Zihai @CedarsSinaiMed and @CSCancerCenter on this landmark paper. Fantastic work highlighting the role of the Y chromsome loss in bladdercancer immune evasion @urotoday https://t.co/wvAmrWBSWk https://t.co/GQCpOCLEaj
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Mashup Score: 0Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling - Nature Communications - 1 year(s) ago
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
UTUC is an FGFR3-driven disease state as we and others showed https://t.co/xrfPot6UpD Agree that FGFR3 genomic alterations do not explain the full benefit. We see the luminal-papillary immune depleted phenotype even in cases with only ⬆️ FGFR3 mRNA expression without mutations https://t.co/PGmEbNKfIF
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Mashup Score: 10Cisplatin, carboplatin shortage prompts rationing of lifesaving drugs—patients will die - The Cancer Letter - 1 year(s) ago
Thousands of cancer patients across the U.S. are getting bewildering news from their oncologists: Proven curative regimens containing platinum-based drugs—cisplatin and carboplatin—have become largely unavailable because of a nationwide drug shortage. The institutions that have some supplies of cisplatin and carboplatin are setting up algorithms for rationing their dwindling stocks, which usually…
Source: The Cancer LetterCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @TheCancerLetter: Cisplatin, carboplatin shortage prompts rationing of lifesaving drugs—patients will die. https://t.co/s8k8Y2BbdV
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Mashup Score: 1
Talks that conference attendees could see in person are more likely to be cited than talks they most likely missed.
Source: www.nature.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Do scientific meetings matter? Turning up for talks brings surprise benefits https://t.co/b29EVK6zrt
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RT @vntranos: Excited that our paper is now published in Nature Genetics: https://t.co/C5dvCXoKeP Overall we show that protein language mo…