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Mashup Score: 5Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity - 6 month(s) ago
Nature – A screen of nutrient-derived compounds identified trans-vaccenic acid as a promoter of effector T cell function, and functional assays demonstrate that this occurs via inactivation of…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes - 11 month(s) ago
There is growing evidence that the metabolism is deeply intertwined with head and neck squamous cell carcinoma (HNSCC) progression and survival but little is known about circulating metabolite patterns and their clinical potential. We performed unsupervised hierarchical clustering of 209 HNSCC patients via pre-treatment plasma metabolomics to identify metabolic subtypes. We annotated the subtypes…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Early interesting data of #HNCA risk stratification by Pre-Treatment Plasma Metabolics @WinshipAtEmory @DeborahWBruner1 @utennpress https://t.co/T3QiIjkTSV #mdpicancers via @Cancers_MDPI
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Mashup Score: 0
KEYNOTE-048 has opened new vistas to managing patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). Nonetheless, uncertainties remain in matching the correct patient with the correct strategy. Join Drs. Barbara Burtness and Nabil Saba as they parse the key trials and offer insight into building treatment algorithms designed to optimize outcomes for your patients…
Source: reachmd.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Happy to share this CME activity covering Personalizing Treatment of Recurrent/Metastatic HNSCC: A Multifactorial Path https://t.co/6vcZsaBupr via @ReachMD
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Mashup Score: 6
Radiotherapy plays an essential role in the treatment of head and neck squamous cell carcinoma (HNSCC), yet radioresistance remains a major barrier to therapeutic efficacy. A better understanding of the predominant pathways determining radiotherapy response could help develop mechanism-informed therapies to improve cancer management. Here we report that radioresistant HNSCC cells exhibit…
Categories: Hem/Oncs, Latest HeadlinesTweet-
c-Met-Signaling mediates resistance to EGFR as well as radio resistance in Head and Neck Cancer; sharing this interesting pre-clinical data https://t.co/aepTMbiSUZ
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Mashup Score: 6Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial - Nature Medicine - 1 year(s) ago
In a phase 2 trial of pembrolizumab and cabozantinib in patients with advanced head and neck cancer, a high clinical benefit rate was achieved, which positively correlated with levels of CD8+ T cell infiltration but not tumor mutational burden.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Sharing our Pembro and Cabo phase 2 RM data @NatureMedicine @WinshipAtEmory@MoffittNews @ExelixisInc @ConorSteuerMD @JMuzaffarMD @DrKedarKirtane @DrHaddadRobert @HeadNeckMD https://t.co/vTuZ2dAfBu
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Mashup Score: 3Insurance authorization and access to proton therapy for patients with head and neck cancers - PubMed - 1 year(s) ago
BIPOC patients were significantly more likely to have insurance plans unfavorable to proton therapy coverage. These PU insurance plans were associated with a longer median time to determination, a lower approval rate for proton therapy, and a longer time to start radiation of any modality.
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Important findings by @markmcdonaldmd that deserve highlighting; @StokedStokes @JamesBatesMD @JillRemickMD @soumon_rudra @sueyom @IJROBP @NRGonc @WinshipAtEmory @EmoryRadOncRes insurance authorization and access to proton therapy for patients with HNCA https://t.co/tvsdSGOZWN
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Mashup Score: 0Patterns of toxicity burden for FDA-approved immune checkpoint inhibitors in the United States - PubMed - 1 year(s) ago
Tissue and organ toxicities of ICIs are age and sex specific. There are risks of respiratory and urinary system toxicity in male patients and reproductive system toxicity in female patients treated with the ICIs studied. Future studies on the toxicity burden of ICIs should incorporate age and sex di …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
An interesting overview of IRAEs patterns and burdens by gender, age and class of the different @FDAOncology approved ICI agents; @WinshipAtEmory @sitcancer https://t.co/m1H2wC5jTt
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Mashup Score: 0Patterns of toxicity burden for FDA-approved immune checkpoint inhibitors in the United States - PubMed - 1 year(s) ago
Tissue and organ toxicities of ICIs are age and sex specific. There are risks of respiratory and urinary system toxicity in male patients and reproductive system toxicity in female patients treated with the ICIs studied. Future studies on the toxicity burden of ICIs should incorporate age and sex di …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
A needed overview of the patterns of IR toxicities of the @FDA approved ICI; interesting differences between PD1 and PDL1 inhibitors @WinshipAtEmory @sitcancer @ASCO https://t.co/m1H2wC5jTt
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Mashup Score: 2The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss - PubMed - 2 year(s) ago
Oropharyngeal squamous cell carcinoma (OPSCC) accounts for over half of all head and neck cancers. Since the 1970s, OPSCC has shifted from an environmentally triggered to virally mediated disease due to a sharp rise in human papillomavirus (HPV)-related SCC. Although a highly effective prophylactic …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
A timely call to action; The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to miss @BarbaraBurtness @WinshipAtEmory @RobertFerrisMD @EmoryVaccineCtr @YaleCancer @UPMCHillmanCC https://t.co/Ba5BihObRg
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Mashup Score: 1
Sinonasal and Skull Base Malignancies by Nabil F. Saba, 9783030976170, available at Book Depository with free delivery worldwide.
Source: www.bookdepository.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Check out our released “Sinonasal and Skull Base Malignancies” textbook; A phenomenal effort with contributions by many talented experts @ Derrick Lin, @MassGenBrigham @WinshipAtEmory @springerpub https://t.co/DCYvaQTHxq via @bookdepository
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Dietary derived nutrient TVA and its effect on effector CD8+ T cell anti tumor immunity; fascinating findings by Jing Chen and colleagues @nature with potential implications on future IO approaches @LesinskiLab https://t.co/1Q9MWNxDQO