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Mashup Score: 69
Nature Microbiology – Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 2Acknowledgment to Reviewers - 9 day(s) ago
The Cancer Research editors wish to acknowledge with sincere appreciation the assistance of the following reviewers who have generously contributed their time and effort during the past year1 in the appraisal of manuscripts. These reviewers have been enormously helpful in assessing the merit of original articles: their careful analysis and critique and their constructive recommendations have greatly enhanced the value of manuscripts they have handled. The quality of the journal can be attributed in large measure to the quality of their effort. We are sincerely grateful.A. Avelar, R.Abal, M.Abdel-Wahab, O.Abdul Pari, A.Abu-Eid, R.Adelaiye-Ogala, R.Adinolfi, E.Adnan, D.Ager, C.Agnihotri, S.Agudo, J.Aguirre, A.Ajani, J.Akbay, E.Akdemir, K.Aktary, Z.Alachkar, H.Aladjem, M.Alexandre Alcantara dos Santos, S.Alitalo, K.Alspach, E.Altea-Manzano, P.Alumkal, J.Alves-Guerra, M.Amati, B.Amatruda, J.Amaya, M.Amend, S.Amit, M.Amor, C.An, W.An, Z.Anant, S.Anbalagan, S.Ando, M.Andrews, M.Anichini, A.A
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
A big thank you to all our 2024 reviewers at @CR_AACR The journal's reputation and quality of papers published would not be where it is without our reviewers donating their time and expertise. @AACR @ciacobu @HarmonyTurk https://t.co/24PGdc8mLg
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Mashup Score: 2Cancer Prevalence across Vertebrates - 9 day(s) ago
Analysis of 16,049 animal necropsies from 292 vertebrate species shows that cancer prevalence increases with body mass and somatic mutation rates, but decreases with gestation time.
Source: aacrjournals.orgCategories: General Medicine News, Hem/OncsTweet-
Link to paper: https://t.co/gJBnkbkAb6
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Mashup Score: 6TrueFood Dashboard - 9 day(s) ago
TrueFood helps select less processed foods in grocery
Source: www.truefood.techCategories: General Medicine News, Hem/OncsTweet-
Select your "healthy" brand at the TrueFood database https://t.co/R2S8Hqpwum https://t.co/UkSmhy2AUR
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Mashup Score: 8GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA AND EXTRA-PANCREATIC MALIGNANCIES: A NATIONWIDE DATABASE ANALYSIS - 10 day(s) ago
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. About 10% of affected individuals have an inherited component. Deleterious germline variants increase the lifetime risk for PDAC and are often associated with an elevated risk for extra-pancreatic malignancies. In this study, we aim to determine the prevalence and impact of germline pathogenic variants (gPVs) in patients with PDAC and extra-pancreatic malignancies. Using tissue samples and longitudinal data from a nationwide pathology database, we identified patients with PDAC and a set of seven extra-pancreatic malignancies to investigate the presence of gPVs in 25 cancer susceptibility genes with targeted next-generation sequencing.
Source: www.modernpathology.orgCategories: General Medicine News, Hem/OncsTweet-
Link to paper below: GERMLINE PATHOGENIC VARIANTS IN PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA AND EXTRA-PANCREATIC MALIGNANCIES: A NATIONWIDE DATABASE ANALYSIS https://t.co/2dEeydyakv
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Mashup Score: 9Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival - 10 day(s) ago
Nature Medicine – Analyses of clinical and genomic data from a cohort of 2,336 patients with pancreatic adenocarcinoma find that KRAS dosage gains are a hallmark of disease progression and are…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
That KRAS Wild type #PancreaticCancer is a distinct entity from KRAS mutant disease was also recently reported by @EileenMOReilly & colleagues in their single institution study from @MSKCancerCenter in @NatureMedicine https://t.co/4gxFsPObfv
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Mashup Score: 6
This cohort study assesses the incidence of KRAS mutations and their association with clinical outcomes based on the most common treatments used in patients with pancreatic ductal adenocarcinoma.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet-
Link to the @JAMANetworkOpen paper below: KRAS Mutation Status and Treatment Outcomes in Patients With Metastatic Pancreatic Adenocarcinoma https://t.co/nsYpkV6dbk
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Mashup Score: 27
The gut microbiome plays an important role in the carcinogenesis of luminal gastrointestinal malignancies and response to antineoplastic therapy. Preclinical studies have suggested a role of intratumoral gammaproteobacteria in mediating response to gemcitabine-based chemotherapy in pancreatic ductal adenocarcinoma (PDAC). To our knowledge, this is the first study to evaluate the impact of the PDAC microbiome on chemotherapy response using samples from human pancreatic tumor resections. We performed 16S rRNA gene amplification and sequencing on both formalin-fixed paraffin-embedded (FFPE) and fresh frozen human PDAC resection samples. We analyzed frozen samples from 26 patients with resected PDAC and examined tumor and tumor-adjacent normal tissue. These patients represented nine long-term survivors (LTS) and nine short-term survivors (STS) after neoadjuvant gemcitabine therapy and eight control patients who did not receive any neoadjuvant therapy prior to resection. We also included FF
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Is there a functionally consequential intratumoral #microbiome in pancreatic cancer or not? New study from @DrGManji & colleagues @columbiacancer Low Bacterial Biomass in Human #PancreaticCancer and Adjacent Normal Tissue https://t.co/IeGVhLlWqm In this study, Gulam examined… https://t.co/APmrzW4lPO
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Mashup Score: 2The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer - 11 day(s) ago
The development of hepatic metastases is the leading cause of mortality in gastrointestinal (GI) cancers and substantial research efforts have been focused on elucidating the intricate mechanisms by which tumor cells successfully migrate to, invade, and ultimately colonize the liver parenchyma. Recent evidence has shown that perturbations in myeloid biology occur early in cancer development, characterized by the initial expansion of specific innate immune populations that promote tumor growth and facilitate metastases.
Source: www.ghadvances.orgCategories: General Medicine News, Hem/OncsTweet-
Link to the review https://t.co/QGwIDxcYrs
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Mashup Score: 5
Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, in part resulting from cellular heterogeneity that supports overall tumorigenicity. Cancer associated fibroblasts (CAF) are key determinants of PDAC biology and response to systemic therapy. While CAF subtypes have been defined, the effects of patient-specific CAF heterogeneity and plasticity on tumor cell behavior remain unclear. Here, multi-omics was used to characterize the tumor microenvironment (TME) in tumors from patients undergoing curative-intent surgery for PDAC. In these same patients, matched tumor organoid and CAF lines were established to functionally validate the impact of CAFs on the tumor cells. CAFs were found to drive epithelial-mesenchymal transition (EMT) and a switch in tumor cell classificiaton from classical to basal subtype. Furthermore, we identified CAF-specific interleukin 8 (IL-8) as an important modulator of tumor cell subtype. Finally, we defined neighborhood relationships betwee
Source: www.biorxiv.orgCategories: General Medicine News, Hem/OncsTweet-
Link to preprint: https://t.co/6gLCC90QTG
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RT @EricTopol: The gut microbiome products and..... —propensity to eat foods high in sugar https://t.co/tXKjwSjZUK @NatureMicrobiol —accel…