TIFAB modulates metabolic pathways in KMT2A::MLLT3−induced AML through HNF4A
Key PointsTIFAB regulates oxidative phosphorylation in AML stem/progenitor cells.HNF4A, a newly identified downstream target of TIFAB, rescues the metaboli
Key PointsTIFAB regulates oxidative phosphorylation in AML stem/progenitor cells.HNF4A, a newly identified downstream target of TIFAB, rescues the metaboli
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Key Points. Triplets provide longer TTNT and improved OS than doublets in Octogenarians.The introduction of daratumumab-based regimens resulted in signific
Key PointsCul5 regulates production of megakaryocyte-committed stem cells to prevent excess megakaryopoiesis.Cul5-deficient megakaryopoiesis is largely ind
Dorothy was shocked when diagnosed with acral melanoma, a rare, dangerous skin cancer. Now, she wants to educate people on what to look for.
Key PointsLCH-HI is life threatening, defined as hemoglobin ≤7 g/dL and/or platelets ≤20 × 109/L.LCH-HI severity, associated with BRAFV600E variant and mac
The FDA approved brentuximab vedotin plus lenalidomide and rituximab for relapsed or refractory large B-cell lymphoma.
Researchers at the @OSUCCC_James have developed an AI algorithm to identify which pancreatic cysts are likely to develop into cancer, and a less-invasive, organ-saving technique…
Key Points:Air pollution exposure is common, and may increase risk of developing blood clots.Greater long-term exposure to air pollution (ie, PM2.5, NOxNO2