As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.
Medical Research Future Fund and National Health and Medical Research Council (Australia), Health Research Council (New Zealand), Royal Australasian College of Physicians, and Baxter.
Qiu et al. identify that reduced mannose metabolism is a key characteristic of T cell dysfunction. Enhancing mannose metabolism in T cells through D-mannose supplementation boosts anti-tumor activity,…
In a recently published article in Device, Saehyun Kim et al. report that selective excitation of bacteria can inhibit their proliferation in an antibiotic-free manner. We…
In vertebrates and flies, brain development relies on the removal of surplus apoptotic neurons by phagocytic glia. Here, Hilu-Dadia et al. describe that Santa-maria, a fly…
Detecting pathogenic germline variants in the clinic remains technically challenging. We analyzed 145 previously identified, hard-to-detect variants in 100 samples using HiFi long-read sequencing (LRS).…
Sodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis
Happy New Year from AJKD! We’d like to take this opportunity to look back on the top ten AJKDBlog posts of 2024. Special thanks to…
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