-
Mashup Score: 5CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory–like Cells - 2 year(s) ago
This article is featured in Top Reads , p.[][1] [1]: /lookup/volpage/208/1515
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
-
Mashup Score: 1The Amer. Assn. of Immunologists - 2 year(s) ago
On June 19, 1913, a group of physician-scientists gathered on the University of Minnesota campus to form a society devoted to a nascent medical specialty–immunology.…
Source: VimeoCategories: Allergy-Immunology, Latest HeadlinesTweet-
Tune in for #PillarTalk: #Treg Influence Decisions between Concomitant Immunity versus Sterile Cure, featuring @EugeneOltz @DeBroski1 & David L. Sacks #PillarsofImmunology #ReadTheJI #bacterialimmunology #Leishmania https://t.co/1tj3sEX9Re https://t.co/Jwks10v4Vg
-
-
Mashup Score: 8Insulin signaling establishes a developmental... - 3 year(s) ago
Systematic characterizations of adipose regulatory T (Treg) cell subsets and their phenotypes remain uncommon. Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor (TCR) sequencing to map mouse adipose Treg cells, we identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns. Analysis of TCR-sharing data implied a state transition between…
Source: www.nature.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Adipose tissue-resident regulatory T (#Treg) cells are important for maintaining normal metabolic function and adiposity. Li and colleagues demonstrate that insulin signaling directly controls adipose Treg cell development and functionality https://t.co/ca9nlf9j7F https://t.co/2zTxfSZeLD
-
-
Mashup Score: 10Acute pharmacological degradation of Helios destabilizes regulatory T cells - Nature Chemical Biology - 3 year(s) ago
Two degraders targeting zinc finger transcription factor IKZF2 (Helios) were developed by reprogramming CRL4CRBN E3 ligase, and the pharmacologic degradation of Helios results in Treg destabilization.
Source: Nature Chemical BiologyCategories: Latest Headlines, Oncologists1Tweet-
SCI leader Nathanael Gray and colleagues developed two degraders that target zinc finger transcription factor Helios and destabilize regulatory T cells. https://t.co/w4ebFsDIUr @nchembio #treg #chembio
-
-
Mashup Score: 0Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury - PubMed - 3 year(s) ago
Obesity-related IL-18 induces Treg dysfunction that may contribute to the pathogenesis of PGD. Evaluation of Treg suppressive function along with IL-18 levels may serve as screening tools to identify pre-transplant obese recipients with increased risk of PGD.
Source: PubMedCategories: Critical Care, Latest HeadlinesTweet-
#Obesity- #related #IL-18 Impairs #Treg #Function and Promotes #Lung #Ischemia- #reperfusion #Injury @ATSBlueEditor #AJRCCM https://t.co/jm5quu1JL2 https://t.co/yfOy9Dyotc
-
-
Mashup Score: 5T Regulatory Cells Influence Decisions between Concomitant Immunity versus Sterile Cure - 3 year(s) ago
Host-protective immunity is dependent upon the generation of inflammatory responses that mediate pathogen clearance, but if left unchecked, it can result in excessive tissue pathology. It is now established that distinct T lymphocyte populations serve inflammatory versus suppressive roles, but these
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#PillarsofImmunology: #Treg Cells Influence Decisions between Concomitant Immunity versus Sterile Cure | Juan M. Inclan-Rico and @DeBroski1 https://t.co/FL4YM5oOQB https://t.co/PhdReNYoZX
-
-
Mashup Score: 7Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells - 3 year(s) ago
Foxp3+ regulatory T (TR) cells are phenotypically and functionally diverse and broadly distributed in lymphoid and nonlymphoid tissues. However, the pathways guiding the differentiation of tissue-resident TR cell populations have not been well defined. By regulating E-protein function, Id3 controls the differentiation of CD8+ effector T cells and is essential for TR cell maintenance and function….
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI_JI from @DJC5651 | #tissueresident #Treg cells develop in a multistep process associated with #Id3 downregulation @BRIautoimmune #CuttingEdge #ReadTheJI #immunology #FreetoRead https://t.co/4sUy1WRCn9 https://t.co/fDoigFeaMl
-
-
Mashup Score: 2
This article is featured in Top Reads , p.[1979][1] [1]: /lookup/volpage/206/1979
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
#JI_TopRead: From researchers @TUS_PR | commensal #gutbacteria regulate #inflammation at distal sites in the #airway via #Treg expansion #microbiome #ReadTheJI #immunology https://t.co/CdCcBASRm8 https://t.co/GnNFojsIKM
-
-
Mashup Score: 5Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut - 3 year(s) ago
The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3+ …
Source: www.sciencedirect.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Benoist, Yan &co reveal a regulatory circuit in which microbial signals condition neuronal density & activation, & neuron-produced IL-6 tunes #Treg cell generation, with implications for intestinal tolerance #neuroimmunology https://t.co/R1blsA5TqR https://t.co/QIxe1F4rX8
-
-
Mashup Score: 1
Key Points. A novel irradiation-based conditioning regimen allows age-adapted myeloablative haploidentical transplantation for leukemia patients.The combination
Source: ashpublications.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Haploidentical age-adapted myeloablative transplant and regulatory and effector T cells for acute myeloid leukemia https://t.co/eGHWvXvbLe… Hard work, but finally out! A new transplant option for our patients! So proud! #transplant #Treg #AML #leukemia https://t.co/FZPWFQCocb
-
#JI_TopRead from David Rawlings @UW | integration of #HIV genes into BACH2 exon in primary #CD4Tcells generates #Treg-like cells #ReadTheJI #immunology #generegulation #LTR https://t.co/wLkqzKVPG0 https://t.co/4uKae3TAxK