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Mashup Score: 20Sex differences orchestrated by androgens at single-cell resolution - 10 month(s) ago
Nature – The effects of sex and androgens on the molecular programs and cellular populations are explored using a single-cell transcriptomic atlas comprising over 2.3 million cells from different…
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Mashup Score: 23FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy - 10 month(s) ago
Nature – Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.
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Mashup Score: 42HOME - Cancer Immunotherapy: From bench to bedside and back - 10 month(s) ago
Join me at this event!
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Mashup Score: 26HOME - Cancer Immunotherapy: From bench to bedside and back - 11 month(s) ago
Join me at this event!
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Mashup Score: 127Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells - 1 year(s) ago
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune responses and clear infected cells will probably be necessary to achieve reduction of the latent reservoir. In the present study, we report two single-chain diabodies (scDbs) that target the HIV-1 envelope protein (Env)…
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Mashup Score: 57Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria - 1 year(s) ago
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses antitumor T cell immunity. However, LA is a natural energy metabolite that can be oxidized in the mitochondria and could potentially stimulate T cells. Here we show that the lactate-lowering mood stabilizer lithium carbonate (LC) can inhibit LA-mediated…
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Mashup Score: 48The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates - 1 year(s) ago
Antigen-experienced CD8+ T cells form effector and central memory T cells (TEM and TCM cells, respectively); however, the mechanism(s) controlling their lineage plasticity remains incompletely understood. Here we show that the transcription cofactor Tle3 critically regulates TEM and TCM cell fates and lineage stability through dynamic redistribution in antigen-responding CD8+ T cell genome….
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Mashup Score: 38BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity - 1 year(s) ago
After a century of using the Bacillus Calmette–Guérin (BCG) vaccine, our understanding of its ability to provide protection against homologous (Mycobacterium tuberculosis) or heterologous (for example, influenza virus) infections remains limited. Here we show that systemic (intravenous) BCG vaccination provides significant protection against subsequent influenza A virus infection in mice. We…
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Mashup Score: 41Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2 - 1 year(s) ago
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of individuals with clear LC and non-LC clinical trajectories, 8 months postinfection. We found that LC individuals…
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Mashup Score: 116Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states - 1 year(s) ago
Memory B cells (MBCs) are phenotypically and functionally diverse, but their developmental origins remain undefined. Murine MBCs can be divided into subsets by expression of CD80 and PD-L2. Upon re-immunization, CD80/PD-L2 double-negative (DN) MBCs spawn germinal center B cells (GCBCs), whereas CD80/PD-L2 double-positive (DP) MBCs generate plasmablasts but not GCBCs. Using multiple approaches,…
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RT @Nature: Nature research paper: Sex differences orchestrated by androgens at single-cell resolution https://t.co/uITGjf5Fgn