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    Background: Although immune checkpoint inhibitors (ICIs) have provided practice-changing outcomes in treating many cancers, ICI-related gastrointestinal toxicity can limit their use. Upper gastrointestinal toxicity is not common nor as well described as lower gastrointestinal toxicity. We aimed to characterize the clinical presentation, endoscopic and…

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    • JUST PUBLISHED: Clinicopathologic Features, Treatment Response, and Outcomes of Immune Checkpoint Inhibitor–Related #Esophagitis: https://t.co/DO2ZMBtUx0 @Path_Wei @MehmetAltanMD @PGrivasMDPhD #toxicity #immunotherapy #adverseevents https://t.co/5Wq2848OP7

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    Cancer immunotherapies can successfully activate immune responses towards certain tumors. However, this can also result in the development of treatment-induced immune-related adverse events (irAEs) in multiple tissues. Growing evidence suggests that cytokine production in response to these therapeutics potentiates the development of irAEs and may have predictive value as biomarkers for irAE…

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    • Read the Feature Review @TrendsImmuno on Predicting & #Preventing #Immune #Checkpoint Inhibitor #Toxicity: Targeting #Cytokines by Jee Hye Kang, Jeffrey Bluestone & Arabella Young #AACR21 https://t.co/Ls4yyEpPj0 https://t.co/kEf02oVAWJ

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    Cardiovascular disease (CVD) is a major source of financial burden and distress, which has three main domains: (1) psychological distress; (2) cost-re…

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    • New: Dr Slavin @sdslavin and colleagues from @MethodistHosp address #financial burden, distress and #toxicity in #cardiovascular diseases and provide action items to overcome related clinical inertia. @haiderwarraich @rohan_khera @jvaleromd @HJRyooAli https://t.co/7vWZ6fZ0BY @NIH https://t.co/YvAszelmZ0

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    Bone & Joint Research - 3 year(s) ago

    Tranexamic acid toxicity in human periarticular tissues

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    • Tranexamic acid (TXA) is an anti-fibrinolytic medication commonly used to reduce perioperative bleeding. This study demonstrates that TXA caused significant periarticular tissue #toxicity ex vivo & in vitro at commonly used clinical concentrations https://t.co/NmcNpfL14p #ortho https://t.co/XhV0fD0TxN

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    When Eating Becomes a Pain in the GutIrritable bowel syndrome often appears following gastrointestinal infection and is marked by diarrhea, dysbiosis, fever, and intestinal pain following eating. A recent study by Aguilera-Lizarraga et al. now demonstrates that a breakdown in intestinal immunotolerance sparks an inflammatory response to typically tolerated food antigens and causes visceral…

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    • Read April issue @TrendsImmuno: #immunity #pain #IBS, #liver #metastasis responsiveness, #tumor #neoantigens, #glioblastoma #macrophage/#microglia, #cytokines & #checkpoint #toxicity, #IFN & #SARSCoV2, #leukocytes & #lamins, #Bcl6 & #Tfh, #ATM & immunity!! https://t.co/yJe57PKnW3 https://t.co/ipv8Ee6tzn