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Mashup Score: 24Non-Metastatic Clear Cell Renal Cell Carcinoma Immune Cell Infiltration Heterogeneity and Prognostic Ability in Patients Following Surgery - 3 month(s) ago
Predicting which patients will progress to metastatic disease after surgery for non-metastatic clear cell renal cell carcinoma (ccRCC) is difficult; however, recent data suggest that tumor immune cell infiltration could be used as a biomarker. We evaluated the quantity and type of immune cells infiltrating ccRCC tumors for associations with metastatic progression following attempted curative surgery. We quantified immune cell densities in the tumor microenvironment and validated our findings in two independent patient cohorts with multi-region sampling to investigate the impact of heterogeneity on prognostic accuracy. For non-metastatic ccRCC, increased CD8+ T cell infiltration was associated with a reduced likelihood of progression to metastatic disease. Interestingly, patients who progressed to metastatic disease also had increased percentages of exhausted CD8+ T cells. Finally, we evaluated the spatial heterogeneity of the immune infiltration and demonstrated that patients without m
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 10Nature Reviews Cancer - Volume 23 Issue 6, June 2023 - 11 month(s) ago
Hermes the messenger, inspired by the Perspective on p408.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Nature Reviews Cancer - Volume 23 Issue 6, June 2023 - 11 month(s) ago
Hermes the messenger, inspired by the Perspective on p408.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 6
Adding anti-PD1 antibodies to 5-FU/platinum chemotherapy improves survival in a subset of advanced gastroesophageal adenocarcinoma (GEA) patients. Beyond PD-L1 expression and mismatch repair status we have limited insight into molecular predictors of response or the relative contribution of PD-1 blockade. We conducted an investigator sponsored phase II trial (n = 47) sequentially adding…
Source: medRxivCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1
Dying tumor cells promote pro-metastatic signaling in surviving neighbor cells by releasing extracellular DNAāprotein complexes enriched in RAGE…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Nature Reviews Cancer - Volume 23 Issue 3, March 2023 - 1 year(s) ago
A splice of bread, inspired by the Review on p135.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our March issue, out NOW! With articles on immomodulating the #TME for #headandneckcancer, as well as the role of RNA splicing dysregulation, STAT proteins and Acetyl-CoA #metabolism in #cancer! There's a loooot to check out in there š š https://t.co/ePYgejyCxI @natrescancer https://t.co/72KFuLP8qC
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Mashup Score: 6Home - 1 year(s) ago
The Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network is part of the Cancer Moonshot Initiative that is intended to accelerate cancer research. Specifically, this network falls under a scientific priority designated by the Blue Ribbon Panel as Recommendation A: Establish a Network for Direct Patient Engagement. The PE-CGS Network will function as a collaborative network to…
Source: Ohio State UniversityCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Targeting tumor microenvironment for cholangiocarcinoma: Opportunities for precision medicine - 1 year(s) ago
Systemic treatments (e.g., chemotherapy and targeted therapies) have limited efficacy for patients with locally advanced ā unresectable ā and metastatā¦
Source: www.sciencedirect.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Pancreatic ductal cells transport bicarbonate from blood to pancreatic juice. A study shows that pancreatic cancer retains SLC4A4-mediated bicarbonate import to fuel cancer growth via enhanced glycolysis and establish a pro-tumorigenic immune microenvironment. Targeting SLC4A4 mitigates acidosis and can be combined with checkpoint blockade.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 7
Researchers at CCR have found that nutrient-deprived solid tumors rely on a steady stream of glutamine, a type of fuel for energy production generated from collagen breakdown in support cells near the tumor. This finding, published November 18, 2022, in Nature Communications, reveals a novel strategy to slow the growth of tumors by blocking collagen uptake ā a pathway not targeted by other…
Source: ccr.cancer.govCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Congrats to Dan Shapiro @wiscurology @UWCarbone for showing @Cancers_MDPI that CD8+ T cells in the #TME of nonmetastatic clear cell renal cell carcinoma are associated with reduced risk of developing metastases later. Exhausted T cells show increased risk https://t.co/qzHstlnrJq