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    Years of life lost to diabetes is a metric that is receiving increasing attention given its potential use in health education and advocacy. People with diabetes have a loss of life expectancy of between 2·5 years and 12·9 years over the lifespan, as shown in multiple high-income populations.1

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    Pregnant women with diabetes continue to have adverse pregnancy outcomes that are often related to hyperglycaemia.1 Tight glycaemic control has been recommended to reduce these adverse outcomes, but it is difficult to achieve these tight glycaemic targets. Part of the reason for this is the difficulty of matching exogenous insulin with glucose excursions, not only because of the difficulty estimating carbohydrate content in foods, but also the difficulty in matching the timing of insulin action with glucose excursions.

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    • Linked Comment by Denice S Feig: Faster and faster: meeting the challenges of delayed #insulin action during #pregnancy https://t.co/uulYR6nTOK #T1D #T2D