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    Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…

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    • #Epidemiology #outcomes Dr. Ye & group data reinforce the importance of treat to target in #lupus management and identified aPLs as another #riskfactors for #SLE #flares to pave the way towards #patient-tailored flare #prevention #strategies in the future. https://t.co/iQg9WdY0Cj

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    Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…

    Tweet Tweets with this article
    • #Epidemiology #outcomes Dr. Ye & group data reinforce the importance of treat to target in #lupus management and identified aPLs as another #riskfactors for #SLE #flares to pave the way towards #patient-tailored flare #prevention #strategies in the future. https://t.co/iQg9WdY0Cj

  • Mashup Score: 0

    Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…

    Tweet Tweets with this article
    • #Epidemiology #outcomes Dr. Ye & group data reinforce the importance of treat to target in #lupus management and identified aPLs as another #riskfactors for #SLE #flares to pave the way towards #patient-tailored flare #prevention #strategies in the future. https://t.co/iQg9WdY0Cj

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    Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of…

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    • The #progress of cardiac Xtx has been immense. The increase of #xenografts #immunocompatibility from genetically engineered pigs, along with targeted immunosuppression, will pave the way to advance further in the field. https://t.co/WxN2bts0KR 9/ https://t.co/kDXxjgZFLU

    • To achieve long-term xenograft survival, various #immunosuppression regimens have been used along with GE pigs. https://t.co/WxN2bts0KR 8/ https://t.co/f99OSdQIyQ

    • Several #genetic #strategies have been developed to prevent early graft failure from preformed antibodies and coagulation dysfunction resulting in generation of GE pigs. https://t.co/WxN2bts0KR 7/ https://t.co/4dRoQPafFv

    • Furthermore, while organs such as kidneys can be accommodated in the abdomen, the growth of a heart xenograft is more problematic, in fact despite several anatomical and physiological similarities between pigs and humans, their growth rate is different. https://t.co/WxN2bts0KR 6/

    • Another potential problem for cardiac Xtx is a zoonotic viral transmission from swine, most notable of which is a porcine endogenous retrovirus. However, studies have shown complete elimination of all copies of it in donor pigs. https://t.co/WxN2bts0KR 5/

    • Coagulation dysregulation is also a major impediment to succeed. The most extreme manifestations are systemic consumptive #coagulopathy, with thrombocytopenia and bleeding, ultimately leading to graft loss for ischemia from thrombotic #microangiopathy. https://t.co/WxN2bts0KR 4/

    • The presence of natural #preformed #antibodies against pig antigens is a primary and significant hurdle for the success of cardiac XTx. Besides, acute cellular #rejection of cardiac xenografts can be mediated by innate and adaptive immune response. https://t.co/WxN2bts0KR 3/

    • In the past few years, substantial progress has been made in the #xenotransplantation (XTx) field. With the discovery and use of novel #molecular #biology techniques, genetically engineered (GE) porcine organ donors have been created. https://t.co/WxN2bts0KR 2/

    • 🥁Hot off the press from Professor Muhammad M. Mohiuddin's group👉Cardiac #Xenotransplantation: #Progress in Preclinical Models and Prospects for Clinical Translation https://t.co/WxN2bts0KR 1/ https://t.co/VVwkzTM2Pb

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    #WhatitTakes #InvestingLegends #PersonalityProfiles #WinningWays #keystosuccessFREE TEST https://www.16personalities.com/free-personality-test 💰Celsius IA P…

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