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Mashup Score: 9
Previous simulation studies investigated the role of reflexes and central pattern generators to explain the kinematic and dynamic adaptations in reaction to step-down perturbations. However, experiments also show preparatory adaptations in humans based on visual anticipation of a perturbation. In this study, we propose a high-level anticipatory strategy augmenting a low-level muscle-reflex…
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Risk factors of disease flares in a Chinese lupus cohort with low-grade disease activity - 2 year(s) ago
Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Risk factors of disease flares in a Chinese lupus cohort with low-grade disease activity - 2 year(s) ago
Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Risk factors of disease flares in a Chinese lupus cohort with low-grade disease activity - 2 year(s) ago
Objective Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Methods Patients with low-grade disease activity (the Safety of Estrogens in Lupus Erythematosus National Assessment–SLE Disease Activity Index (SELENA-SLEDAI) =≤6, daily prednisone…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
Noninvasive Respiratory Strategies and Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19-Reply
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Personalized Management Strategies in Mast Cell Disorders: ECNM-AIM User´s Guide for Daily Clinical Practice* - 2 year(s) ago
Mastocytosis is a myeloid neoplasm defined by expansion and focal accumulation of clonal mast cells (MC) in one or more organs. The disease exhibits a complex pathology and may be complicated by MC activation, bone abnormalities, neurological problems, gastrointestinal symptoms, and/or hematologic progression. The World Health Organization divides mastocytosis into cutaneous forms, systemic…
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation - 2 year(s) ago
Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of…
Source: FrontiersCategories: Latest Headlines, TransplantationTweet-
The #progress of cardiac Xtx has been immense. The increase of #xenografts #immunocompatibility from genetically engineered pigs, along with targeted immunosuppression, will pave the way to advance further in the field. https://t.co/WxN2bts0KR 9/ https://t.co/kDXxjgZFLU
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To achieve long-term xenograft survival, various #immunosuppression regimens have been used along with GE pigs. https://t.co/WxN2bts0KR 8/ https://t.co/f99OSdQIyQ
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Several #genetic #strategies have been developed to prevent early graft failure from preformed antibodies and coagulation dysfunction resulting in generation of GE pigs. https://t.co/WxN2bts0KR 7/ https://t.co/4dRoQPafFv
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Furthermore, while organs such as kidneys can be accommodated in the abdomen, the growth of a heart xenograft is more problematic, in fact despite several anatomical and physiological similarities between pigs and humans, their growth rate is different. https://t.co/WxN2bts0KR 6/
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Another potential problem for cardiac Xtx is a zoonotic viral transmission from swine, most notable of which is a porcine endogenous retrovirus. However, studies have shown complete elimination of all copies of it in donor pigs. https://t.co/WxN2bts0KR 5/
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Coagulation dysregulation is also a major impediment to succeed. The most extreme manifestations are systemic consumptive #coagulopathy, with thrombocytopenia and bleeding, ultimately leading to graft loss for ischemia from thrombotic #microangiopathy. https://t.co/WxN2bts0KR 4/
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The presence of natural #preformed #antibodies against pig antigens is a primary and significant hurdle for the success of cardiac XTx. Besides, acute cellular #rejection of cardiac xenografts can be mediated by innate and adaptive immune response. https://t.co/WxN2bts0KR 3/
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In the past few years, substantial progress has been made in the #xenotransplantation (XTx) field. With the discovery and use of novel #molecular #biology techniques, genetically engineered (GE) porcine organ donors have been created. https://t.co/WxN2bts0KR 2/
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Mashup Score: 0Got what it takes to be a Legendary Investor? Find out! - 2 year(s) ago
#WhatitTakes #InvestingLegends #PersonalityProfiles #WinningWays #keystosuccessFREE TEST https://www.16personalities.com/free-personality-test 💰Celsius IA P…
Source: YouTubeCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 0Self-Advocacy in Healthcare - 2 year(s) ago
Discover these helpful strategies to better advocate for yourself while seeking medical care.
Source: Verywell HealthCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0
isrctn.org Identifier: ISRCTN16912075.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
#Computersimulations show effectiveness of muscular control #strategies used while walking @unibt @SciReports https://t.co/zznMkBeHIc https://t.co/2xoTMYx13H