• Mashup Score: 1
    Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche - PubMed - 2 year(s) ago

    Aging is the final stage of development with stereotyped changes in tissue morphology. These age-related changes are risk factors for a multitude of chronic lung diseases, transcending the diverse pathogenic mechanisms that have been studied in disease-specific contexts. Two of the hallmarks of agin …

    Source: PubMed
    Categories: Latest Headlines, Pulmonology
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      ATS_BSHSR

      Intersection of #Inflammation and #Senescence in the #Aging #Lung #Stem #Cell #Niche https://t.co/3Br1Jb8JFH https://t.co/uprWVEYav5

  • Mashup Score: 0
    What's Your Biological Age? A New 'Aging Clock' Has the Answer - 2 year(s) ago

    The clock used a simple statistical model, which looked at a certain type of epigenetic modification at just two target sites on DNA.

    Source: Singularity Hub
    Categories: Healthcare Professionals, Latest Headlines
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      westr

      New ‘#Aging Clock’: #Epigenetic age. https://t.co/ZvPIhtGPad https://t.co/lAjP18NNIC Epigenetic aging is distinct from cellular #senescence, #telomere attrition, genomic instability, and associated with #nutrient sensing, #mitochondria activity and #stemcell composition. #EpiAge https://t.co/XnBwOGwHvP

  • Mashup Score: 3
    Volume 22 Issue 6, June 2022 - 2 year(s) ago

    Editorial Editorial …

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      Our June issue, out NOW! With articles on #therapyresistance, #senescence & targeting CDK4 & CDK6 in #cancer! Plus, a Comment on cancer mRNA vaccines as well as the launch of our new Tools of the Trade articles #NRCToT. So much content 👇🏻 💌 https://t.co/Fo6XRWV3OZ @natrescancer https://t.co/rbxRPqLV6g

  • Mashup Score: 3
    Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence - 2 year(s) ago

    The capability of tumour cells to escape from therapy-induced senescence, as well as cell-non-autonomous functions of senescence, support the premise that senescence could serve as one pathway to tumour dormancy (among others that include quiescence and diapause) that is permissive for disease recurrence. Consequently, the pharmacologic targeting of senescent tumour cells could mitigate the risk…

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      BrJCancer

      Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence Read for free using #SharedIt: https://t.co/8NOYoekwUK #Chemotherapy #Senescence https://t.co/Y1PTzsbZAx

  • Mashup Score: 26
    Exploiting senescence for the treatment of cancer - Nature Reviews Cancer - 2 year(s) ago

    This Review discusses how senescence can be induced in cancer cells and how distinctive features of senescent cancer cells might be exploited for their selective eradication as a potential cancer therapy.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      NEW Review! Wang, Lankhorst & Bernards discuss how #senescence can be induced in cancer cells and how features of senescent cancer cells might be exploited as potential therapy. https://t.co/8pXnsmNvVI @natrescancer @oncodeinstitute @NKI_nl https://t.co/7GrFJwUdzE

  • Mashup Score: 0
    tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR - 2 year(s) ago

    Author summary Senescence is a tumor suppressive mechanism induced in response to oncogenes or chemotherapy. Senescence was initially defined as a definitive arrest of cell proliferation but doubts have emerged as to the value of this mechanism in terms of suppression. Recent findings published by several laboratories including our own have shown that some cells escape senescence to become more…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      How can cells escape #senescence? Guillon et al identify specific tRNAs controlled by mTOR that are differently expressed in growing, senescent or emerging cells They find corresponding tRNA ligases are required for senescence escape https://t.co/XT2MKzqZd6

  • Mashup Score: 1
    tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR - 2 year(s) ago

    Author summary Senescence is a tumor suppressive mechanism induced in response to oncogenes or chemotherapy. Senescence was initially defined as a definitive arrest of cell proliferation but doubts have emerged as to the value of this mechanism in terms of suppression. Recent findings published by several laboratories including our own have shown that some cells escape senescence to become more…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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    • Profile photo of PLOSGenetics
      PLOSGenetics

      How can cells escape #senescence? Guillon et al @icat_sfr identify specific tRNAs controlled by mTOR that are differently expressed in growing, senescent or emerging cells They find corresponding tRNA ligases are required for senescence escape https://t.co/XT2MKzIA4E

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