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    Background Parkinson’s disease is generally asymptomatic at earlier stages. At an early stage, there is an extensive progression in the neuropathological hallmarks, although, at this stage, diagnosis is not possible with currently available diagnostic methods. Therefore, the pressing need is for susceptibility risk biomarkers that can aid in better diagnosis and therapeutics as well can objectively serve to measure the endpoint of disease progression. The role of small extracellular vesicles (sEV) in the progression of neurodegenerative diseases could be potent in playing a revolutionary role in biomarker discovery. Methods In our study, the salivary sEV were efficiently isolated by chemical precipitation combined with ultrafiltration from subjects (PD = 70, healthy controls = 26, and prodromal PD = 08), followed by antibody-based validation with CD63, CD9, GAPDH, Flotillin-1, and L1CAM. Morphological characterization of the isolated sEV through transmission electron microscopy. The qu

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    • New research from @aiims_newdelhi finds #Fluorescence-tagged salivary small #extracellularvesicles to have potential in screening the progression of early #Parkinsonsdisease https://t.co/52WIzxWQmT @SimranR61580474 #SarojKumarlab #clinicaldiagnostics #nanotool https://t.co/Qt8NIUxpEy

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    Blood test could enable earlier diagnosis and expedite treatment as well as stratify patients for inclusion in clinical trials for new treatments.

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    • Researchers headed by a team at @DukeMedSchool have developed a blood test that detects #Parkinsonsdisease, potentially establishing a way to help diagnose the condition before nervous system damage worsens. Learn more: https://t.co/C9avteWXc1 https://t.co/wJuwH869tQ