• Mashup Score: 0

    Objectives We aim to assess the association of cardiovascular medications with outcomes of patients referred to the diagnostic heart failure (HF) clinic with symptoms or signs of possible HF, raised N-terminal pro-brain-type natriuretic peptide (NT-proBNP) but no evidence of HF on transthoracic echocardiography (TTE). Methods Data were collected prospectively into the Sheffield HEArt Failure…

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    • CV medication in patients with raised #NTproBNP, but no #HeartFailure in the Sheffield HF (SHEAF) registry 1766 pts with ⬆️ #NT-proBNP with no evidence of #HF on #TTE Mortality was ⬆️ with 🧔‍♂️ gender, VHDs and #CKD https://t.co/H8B53D74uZ @Open_HeartBMJ @Heart_BMJ @mmamas1973 https://t.co/1YHif2jfC8

  • Mashup Score: 3

    Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction are at a high risk of developing heart failure. The addition of neprilysin inhibition to renin angiote

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    • 4/5 Median time after AMI was 3.6 y, and thus this study did not assess the effect of Sac/Val on early remodeling in the acute phase of MI. https://t.co/KAhiukkRUF #AHAJournals

    • 3/5 Median #NTproBNP was 230 mg/ml, lower than most #HFrEF pts, and exploratory analysis showed sign reverse remodeling in those with #NTproBNP above median. https://t.co/KAhiukkRUF #AHAJournals https://t.co/D7SwWZ3XbI

    • 2/5 No significant difference was present for the primary outcome of #LVESVI, and also the secondary #CMR and #biomarker outcomes https://t.co/KAhiukkRUF #AHAJournals https://t.co/kzHHZKMKsG

    • 1/5 #RCT of 93 pts w EF<40% after #AMI, but w/o #HF: 52w #Sac/Val vs valsartan did not sign reverse cardiac remodeling or reduce #NTproBNP/#troponin. @Kieranfdocherty https://t.co/KAhiukkRUF #AHAJournals https://t.co/P5nDZrSpCy