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    Currently, mankind has succeeded in increasing life expectancy above 60 years worldwide, with even more impressive achievements in developed countries, such as Japan (over 82 years), Australia (over 80 years), or Europe. However, this increase is at the expense of the increased prevalence of neurodegenerative diseases, especially dementia.Aging is an inherent process in all living organisms, and…

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    • Researching the Mechanisms of Brain Aging? Why not take a look at the new topic in Frontiers in Aging Neuroscience, open for papers NOW! To register your interest or find out more, follow this link: https://t.co/V2Rhd0EcRv #research #neurodegeneration #submissions #OpenAccess https://t.co/IJF2jydoHo

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    Metabolic syndrome and obesity involve dysregulation of adipokines (leptin, adiponectin) and hyperglycemia caused by the gradual development of insulin resistance and type 2 diabetes. Recently, progranulin has also been described as an adipokine involved in insulin signaling. Adipokines are particularly regulated by the intake of fat, and different types of fat have an impact on lipid rafts,…

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    • 🚨Deadline extended🚨 Last chance to get involved in this exciting Research Topic led by Johanna Ojala, Ana Ledo and Jennifer Griffin via Frontiers in Neuroscience 🗓️Deadline: 15 April 2023 Submit today▶️https://t.co/wmyLHy0tAM #lipidrafts #neurodegeneration #metabolism https://t.co/ocXUqP1PDd

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    17 Mar 2023 Here’s a tau twist that may take some adapting to. CD4+ and CD8+ T cells, yes, those mercurial executioners of the immune system, may be responsible for the neurodegeneration seen in Alzheimer’s disease and other tauopathies. That’s the scenario outlined by David Holtzman, Washington University, St. Louis, and colleagues in Nature on March 8. The scientists report that,…

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    • #Neurodegeneration—It’s Not the Tangles, It’s the #TCells https://t.co/571GEFzpMZ #microglia #CD8+ #meninges #brain #parenchyma #immunity #PD1 #dementia #amyloid #tau #Aβ Activated immune cells drive neurodegeneration in an #Alzheimer’s model https://t.co/VUaJjzkPk7 Can #AD… https://t.co/UGZigewVsm https://t.co/3BL4qnK4CR

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    The spatial and temporal development of the brain, overlying meninges (fibroblasts, vasculature and immune cells) and calvarium are highly coordinated…

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    • REVIEW: Stuck on you: #Meninges cellular crosstalk in #development. @SiegenthalerLab https://t.co/o1HQ1T2mYy #brain #duramater #Arachnoiditis #biomarkers Expeditious approach to role of #leptomeninges & #BBB in health and #neurodegeneration See also: https://t.co/vdrPDKA2qW https://t.co/JPTTEbr1Wq