-
Mashup Score: 1Genomic Alterations in Molecularly Defined... : Neurosurgery - 1 day(s) ago
er, previous studies predominantly used research panels that are not readily available to providers and patients. Accordingly, we explore genomic alterations in molecularly defined oligodendrogliomas using clinically standardized next-generation sequencing (NGS) panels. METHODS: A retrospective single-center study evaluated adults with pathologically confirmed IDH-mutant, 1p/19q-codeleted oligodendrogliomas diagnosed between 2005 and 2021. Genetic data from formalin-fixed, paraffin-embedded specimens were analyzed with the NGS Solid Tumor Panel at the Johns Hopkins Medical Laboratories, which tests more than 400 cancer-related genes. Kaplan-Meier plots and log-rank tests compared progression-free survival (PFS) and overall survival by variant status. χ2 tests, t-tests, and Wilcoxon rank-sum tests were used to compare clinical characteristics between genomic variant status in the 10 most frequently altered genes. RESULTS: Two hundred and seventy-seven patients with molecularly defined o
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet
-
Mashup Score: 6Caudal Agenesis: Classification Based on the... : Neurosurgery - 3 month(s) ago
level of conus, considering both its shape and filum. We evaluated its accuracy in reflecting the neurological status and the need for untethering. METHODS: Patients with radiologic studies available on our institute’s electronic image view system between 1985 and 2019 were reviewed. Our classification categorized patients with CA into 3 groups: the failure of formation (a conus level > L1 or normal level conus with a blunt shape), the failure of regression (a conus level < L3 or normal level conus with a thickened filum or a filar lipoma), and the normal (a normal level conus without specific abnormalities). We analyzed which of the following 3 classifications better reflects the neurological status and the probability of recommending untethering: classifications based on (1) bony defect level, (2) conus level, and (3) pathoembryogenic mechanism. RESULTS: A total of 89 patients were included in this study. The pathoembryogenic classification revealed more significant differences in mo
Source: journals.lww.comCategories: General Medicine News, NeurologyTweet-
RT @NeurosurgeryCNS: #NEUNew Caudal Agenesis: Classification Based on the Pathoembryogenesis of the Spinal Cord https://t.co/mUMAHNb32q by…
-
-
Mashup Score: 3Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, NeurologyTweet-
RT @NeurosurgeryCNS: #NEUNew Long-Term Durability of Stand-Alone Lateral #Lumbar Interbody Fusion https://t.co/PJpnBbhrZR by @NitinAgarwalM…
-
-
Mashup Score: 5Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, NeurologyTweet-
RT @NeurosurgeryCNS: #NEUNew #NEUEditorial On Chatbots and Generative Artificial Intelligence https://t.co/w4Xaqg6SFx by @DKondziolkaCNS an…
-
-
Mashup Score: 4Wolters Kluwer Health - 2 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Latest Headlines, NeurologyTweet-
RT @NeurosurgeryCNS: #NEUNew #NEUEditorsChoice Intellectual Property Protection in Neurosurgery: An Overview https://t.co/lVqdY80WT3 by Dyk…
-
RT @NeurosurgeryCNS: #NEUNew Genomic Alterations in Molecularly Defined Oligodendrogliomas https://t.co/U0iHwbZsZL by Weber-Levine et al @H…