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Mashup Score: 12Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging - 1 year(s) ago
Background and Objectives Relapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody–positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) may have overlapping clinical features. There is an unmet need for imaging markers that differentiate between them when serologic testing is unavailable or ambiguous….
Source: NeurologyCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 3Frequency of New or Enlarging Lesions on MRI Outside of Clinical Attacks in Patients With MOG-Antibody–Associated Disease - 1 year(s) ago
Background and Objective To determine the frequency of new or enlarging T2-hyperintense or enhancing lesions outside of clinical attacks in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) vs multiple sclerosis (MS) and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Methods We retrospectively included Mayo Clinic patients with MOGAD…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
This study found new or enlarging lesions outside of attacks rarely developed on surveillance brain MRI in #MOGAD differing from #MS. Read the open access article: https://t.co/inMP11cMeL #NeuroTwitter https://t.co/HoCQKhUUY8
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Mashup Score: 6Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination - 1 year(s) ago
Background and Objectives Acute inflammatory CNS diseases include neuromyelitis optica spectrum disorders (NMOSDs) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). Both MOGAD and acute disseminated encephalomyelitis (ADEM) have been reported after vaccination. Consequently, the mass SARS-CoV-2 vaccination program could result in increased rates of these conditions. We…
Categories: Latest Headlines, NeurologyTweet-
In this study, Francis and colleagues describe the features of patients presenting with new acute CNS demyelination resembling #NMOSD or #MOGAD within 8 weeks of SARS-CoV-2 vaccination. Read the article: https://t.co/pkYK3ekFsD #COVID https://t.co/2MnKlOQW9S
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Mashup Score: 5MOG Antibody–Associated Disease and Thymic Hyperplasia - 1 year(s) ago
Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic…
Categories: Latest Headlines, NeurologyTweet-
MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings https://t.co/tYVQmdsjm1 #NeuroTwitter #MS #MOGAD https://t.co/gD7ifRxUUG
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Mashup Score: 4Pearls & Oy-sters: Tumefactive Demyelinating Lesions With MOG Antibodies Preceding Late Infantile Metachromatic Leukodystrophy - 1 year(s) ago
The development of acute neurologic dysfunction associated with tumefactive demyelinating lesions and mild diffuse involvement of the corpus callosum has been described in children as a sentinel event that may allow diagnosis of juvenile metachromatic leukodystrophy (MLD) at an early and potentially treatable stage. We report a child who developed this clinico-radiologic pattern associated with…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Tumefactive demyelinating lesions and involvement of the splenium of the corpus callosum with or without MOG antibodies in a child may be a clue for early diagnosis of late infantile metachromatic leukodystrophy. Learn more: https://t.co/Etp2weQ9ZT #NeurologyRF #MOGAD https://t.co/RxaoxafYkR
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Mashup Score: 3Early Immunotherapy and Longer Corticosteroid Treatment Are Associated With Lower Risk of Relapsing Disease Course in Pediatric MOGAD - 1 year(s) ago
Background and Objectives We sought to identify early factors associated with relapse and outcome in paediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD). Methods In a multicenter retrospective cohort of pediatric MOGAD (≤18 years), onset features and treatment were compared in patients with monophasic vs relapsing disease (including cases with follow-up ≥12…
Categories: Latest Headlines, NeurologyTweet-
Early Immunotherapy and Longer Corticosteroid Treatment Are Associated With Lower Risk of Relapsing Disease Course in Pediatric #MOGAD: https://t.co/tX4DmDdI8Z #NeuroTwitter #Neurology https://t.co/rfTqS3BNEF
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Mashup Score: 6Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination - 1 year(s) ago
Background and Objectives Acute inflammatory CNS diseases include neuromyelitis optica spectrum disorders (NMOSDs) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). Both MOGAD and acute disseminated encephalomyelitis (ADEM) have been reported after vaccination. Consequently, the mass SARS-CoV-2 vaccination program could result in increased rates of these conditions. We…
Categories: Latest Headlines, NeurologyTweet-
In this study, Francis and colleagues describe the features of patients presenting with new acute CNS demyelination resembling #NMOSD or #MOGAD within 8 weeks of SARS-CoV-2 vaccination. Read the article: https://t.co/pkYK3ekFsD #COVID https://t.co/7nvWEg0NCq
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Mashup Score: 2Long-term Effectiveness and Safety of Rituximab in Neuromyelitis Optica Spectrum Disorder and MOG Antibody Disease - 1 year(s) ago
Background and Objectives Rituximab is used widely for relapse prevention in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein (MOG)-IgG–associated disease (MOGAD); however, data regarding the effectiveness and safety of long-term rituximab use in these conditions are limited. In this study, we sought to evaluate long-term clinical outcomes in patients with…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
Long-term Effectiveness and Safety of Rituximab in Neuromyelitis Optica Spectrum Disorder and MOG Antibody Disease: https://t.co/A5SOiMoSp1 #NeuroTwitter #NMOSD #MOGAD https://t.co/nonN2miJwF
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Mashup Score: 4Area Postrema Syndrome - 1 year(s) ago
Objectives Area postrema syndrome (APS) is one of the core clinical features of neuromyelitis optic spectrum disorder (NMOSD). APS is mostly associated with neuromyelitis optica (NMO) and rarely reported in myelin oligodendrocyte glycoprotein antibody disease. We herein report a case of APS as an initial presentation of double-seropositive aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG)…
Source: Neurology Clinical PracticeCategories: Latest Headlines, NeurologyTweet-
Ranjan and colleagues report a case of area postrema syndrome as an initial presentation of double-seropositive aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) antibodies. Read the clinical/scientific note: https://t.co/Z9azou6wKO #MOGAD #NeuroTwitter https://t.co/l7ClzYwctO
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Mashup Score: 6Frequency of New or Enlarging Lesions on MRI Outside of Clinical Attacks in Patients With MOG-Antibody–Associated Disease - 2 year(s) ago
Background and Objective To determine the frequency of new or enlarging T2-hyperintense or enhancing lesions outside of clinical attacks in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) vs multiple sclerosis (MS) and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Methods We retrospectively included Mayo Clinic patients with MOGAD…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
This study found new or enlarging lesions outside of attacks rarely developed on surveillance brain MRI in #MOGAD differing from #MS. Read the open access article: https://t.co/inMP11cMeL #NeuroTwitter https://t.co/b7GzrTDby8
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This study assessed whether imaging characteristics typical of MS discriminate relapsing-remitting #MS from aquaporin-4 antibody–positive #NMOSD and #MOGAD, alone and in combination. Read the results now: https://t.co/I96053rJBB https://t.co/r8kZqMZLZh