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Mashup Score: 0Immune Repertoire Profiling Reveals Its Clinical Application Potential and Triggers for Neuromyelitis Optica Spectrum Disorders - 10 month(s) ago
Background and Objectives Neuromyelitis optica spectrum disorders (NMOSD) is widely recognized as a CNS demyelinating disease associated with AQP4-IgG (T cell–dependent antibody), and its trigger is still unclear. In addition, although the treatment of NMOSD currently can rely on traditional immunosuppressive and modulating agents, effective methods to predict the efficacy of these therapeutics…
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Mashup Score: 0Synthetic Cell-Based Immunotherapies for Neurologic Diseases - 10 month(s) ago
The therapeutic success and widespread approval of genetically engineered T cells for a variety of hematologic malignancies spurred the development of synthetic cell-based immunotherapies for CNS lymphoma, primary brain tumors, and a growing spectrum of nononcologic disease conditions of the nervous system. Chimeric antigen receptor effector T cells bear the potential to deplete target cells with…
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Review: Synthetic Cell-Based Immunotherapies for Neurologic Diseases https://t.co/FU6aoeNcPF #NeuroTwitter #Neurology https://t.co/zYTQk4oMwf
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Mashup Score: 3Neurology - Neuroimmunology Neuroinflammation: 10 (4) - 10 month(s) ago
Acknowledgment to ReviewersResearch Articles Open Access Treatment With Erythropoietin for Patients With Optic NeuritisLong-term Follow-up Sebastian Küchlin, Gabriele Ihorst, Birgit Grotejohann, Flemming Beisse, Sven P. Heinrich, Philipp Albrecht, Judith Ungewiss, Michael Wörner, Martin J. Hug, Sebastian Wolf, Ricarda Diem, Wolf A. Lagrèze …
Categories: Latest Headlines, NeurologyTweet-
The July 2023 issue of Neurology: Neuroimmunology & Neuroinflammation is now online! All articles are free to read: https://t.co/S2yq724zol #NeuroTwitter https://t.co/2feftuorwl
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Mashup Score: 2Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy - 10 month(s) ago
Objectives JC virus granule cell neuronopathy is a potentially fatal otherwise highly disabling disease without an approved therapeutic option. This case report presents the positive record to T-cell therapy in JC virus granule cell neuronopathy. Methods The patient represented with subacute cerebellar symptoms. Diagnosis of JC virus granule cell neuronopathy was made because of infratentorially…
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Grote-Levi and colleagues present the case report of a positive response to T-cell therapy in JC virus granule cell neuronopathy leading to an improvement of symptoms. https://t.co/9DO7EdCinB #NeuroTwitter https://t.co/UD2tqu6oyI
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Mashup Score: 2Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis - 10 month(s) ago
Background and Objective Despite accumulating evidence of intrathecal inflammation in patients with primary progressive multiple sclerosis (PPMS), immunomodulatory and suppressive treatment strategies have proven unsuccessful. With this study, we investigated the involvement of CD20+ T cells and the effect of dimethyl fumarate on CD20+ T cells in PPMS. Methods The main outcomes in this…
Categories: Latest Headlines, NeurologyTweet-
This study investigated the involvement of CD20+ T cells and the effect of dimethyl fumarate on CD20+ T cells in primary progressive multiple sclerosis. Read the open access article: https://t.co/s8L9LI7Pwk #NeuroTwitter #MS https://t.co/5Yy0MOYLM7
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Mashup Score: 0TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis - 10 month(s) ago
Background and Objectives In the multiple sclerosis (MS) brain, chronic active lesions can be detected using MRI- and PET-based methods. In this study, we investigated whether the frequency of TSPO-PET–detectable chronic active lesions associates with disease progression measured using the Expanded Disability Status Scale (EDSS) at 5-year follow-up. Methods Chronic lesion–associated innate…
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Study results show that single TSPO-PET–based in vivo lesion phenotyping of chronic multiple sclerosis (MS) lesions provides a strong predictor for #MS disease progression. Learn more: https://t.co/GkI17BjNos #NeuroTwitter https://t.co/SQ1dmSrS6o
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Mashup Score: 0Frequency and Referral Patterns of Neural Antibody Studies During the COVID-19 Pandemic - 11 month(s) ago
Objective To determine whether the frequency of paraneoplastic or autoimmune encephalitis antibodies examined in a referral center changed during the COVID-19 pandemic. Methods The number of patients who tested positive for neuronal or glial (neural) antibodies during pre–COVID-19 (2017–2019) and COVID-19 (2020–2021) periods was compared. The techniques used for antibody testing did not change…
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Frequency and Referral Patterns of Neural Antibody Studies During the #COVID-19 Pandemic: Experience From an Autoimmune Neurology Center https://t.co/za6n7BMIr4 #NeuroTwitter https://t.co/mCcOTF5Zc9
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Mashup Score: 0Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia - 11 month(s) ago
Objectives Vaccine-induced immune thrombotic thrombocytopenia (VITT), a recently described entity characterized by thrombosis at unusual locations such as cerebral venous sinus and splanchnic vein, has been rarely described after adenoviral-encoded COVID-19 vaccines. In this study, we report the immunohistological correlates in 3 fatal cases of cerebral venous thrombosis related to VITT analyzed…
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This study reports the immunohistological correlates in 3 fatal cases of cerebral venous thrombosis related to vaccine-induced immune thrombotic thrombocytopenia after adenoviral COVID-19 vaccination, analyzed at an academic medical center: https://t.co/mJeJLAP4mF #NeuroTwitter https://t.co/Wefgjwv91x
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Mashup Score: 0Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits in the Long-term Course of Limbic Encephalitis - 11 month(s) ago
Background and Objectives Limbic encephalitis (LE) is an autoimmune disease often associated with temporal lobe epilepsy and subacute memory deficits. It is categorized into serologic subgroups, which differ in clinical progress, therapy response, and prognosis. Using longitudinal MRI analysis, we hypothesized that mesiotemporal and cortical atrophy rates would reveal serotype-specific patterns…
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This longitudinal case-control study investigated whether mesiotemporal and cortical atrophy rates would reveal serotype-specific patterns and reflect disease severity in patients with limbic encephalitis: https://t.co/vP4AG33xmV #NeuroTwitter https://t.co/NFGAYKxZLG
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Mashup Score: 2Anti-LGI1 Encephalitis With Co-occurring IgLON5 Antibodies - 11 month(s) ago
Objectives Autoimmune encephalitis (AE) with antibodies against LGI1 and IgLON5 are clinically distinctive but share some particularities such as a strong association with specific human leukocyte antigen (HLA) class II alleles. Methods We clinically describe a patient with double positivity for LGI1 and IgLON5 antibodies. In addition, we conducted specific immunodepletion with the patient’s…
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Anti-LGI1 Encephalitis With Co-occurring IgLON5 Antibodies: Clinical Features and Human Leukocyte Antigen Haplotypes https://t.co/iT8FWlkzGP #NeuroTwitter https://t.co/kyVjD7XbXm
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This study's findings suggest that the occurrence of AQP4 immunoglobulin G+ neuromyelitis optica spectrum disorder (#NMOSD) may be associated with cytomegalovirus infection. Read the open access article: https://t.co/4gAg5No8nS #NeuroTwitter https://t.co/zo1JNu4Ptv