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Mashup Score: 2Multiple Sclerosis Disease Activity and Disability Following Cessation of Fingolimod for Pregnancy - 12 month(s) ago
Background and Objective Discontinuation of fingolimod ≥2 months before pregnancy is recommended to minimize potential teratogenicity. The magnitude of MS pregnancy relapse risk, particularly severe relapses, after fingolimod cessation is unclear, as is whether this risk is reduced by pregnancy or modifiable factors. Methods Pregnancies who stopped fingolimod treatment within 1 year before or…
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Mashup Score: 0Multiple Sclerosis Disease Activity and Disability Following Cessation of Fingolimod for Pregnancy - 12 month(s) ago
Background and Objective Discontinuation of fingolimod ≥2 months before pregnancy is recommended to minimize potential teratogenicity. The magnitude of MS pregnancy relapse risk, particularly severe relapses, after fingolimod cessation is unclear, as is whether this risk is reduced by pregnancy or modifiable factors. Methods Pregnancies who stopped fingolimod treatment within 1 year before or…
Categories: Latest Headlines, NeurologyTweet-
According to this study, #MS relapses during pregnancy after #fingolimod cessation are common. Approximately 6% of women will retain clinically meaningful disability from these pregnancy-related, fingolimod cessation relapses 1 year postpartum. https://t.co/tB8Xy4SYTk https://t.co/crnGvIs1Vi
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Mashup Score: 0Anti–GABA-A Receptor Antibody-Mediated Epilepsia Partialis Continua After Treatment With Alemtuzumab - 12 month(s) ago
Background and Objectives Patients with anti–GABA-A receptor encephalitis characteristically experience therapy-refractory epileptic seizures. General anesthesia is often required to terminate refractory status epilepticus. The immunologic mechanisms leading to antibody formation remain to be elucidated. Described triggers of anti–GABA-A autoimmunity are tumors, mainly thymomas, and herpes…
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This case describes a severe autoantibody-induced encephalitis in a young patient with multiple sclerosis, with alemtuzumab as a potential trigger for anti–GABA-A receptor encephalitis. https://t.co/gT4Lf6dRDq #NeuroTwitter #MS https://t.co/d2zUFarUAj
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Mashup Score: 3
Objectives Adenosine deaminase 2 deficiency (DADA2) is a genetic, neurologic, and systemic vasculitis syndrome, which can lead to recurrent strokes, typically lacunar. In the cohort of now 60 patients followed up at the NIH Clinical Center (NIH CC), no patient has had a stroke since starting tumor necrosis factor (TNF) blockade. We present a family with multiple affected children to highlight the…
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This case series illustrates the importance of testing for DADA2 in young patients with cryptogenic stroke, given the hemorrhagic risks with antiplatelet drugs in these patients & effectiveness of TNF blockade as secondary stroke prevention. https://t.co/0zHY8d7hUI #NeuroTwitter https://t.co/Ub9qQln1eW
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Mashup Score: 1
Background and Objectives SARS-CoV-2 infection has been associated with a syndrome of long-term neurologic sequelae that is poorly characterized. We aimed to describe and characterize in-depth features of neurologic postacute sequelae of SARS-CoV-2 infection (neuro-PASC). Methods Between October 2020 and April 2021, 12 participants were seen at the NIH Clinical Center under an observational…
Categories: Latest Headlines, NeurologyTweet-
This report describes clinical, laboratory, and imaging findings in a small but comprehensively tested cohort of patients with neuro-postacute sequelae of SARS-CoV-2 infection. Learn more: https://t.co/cHZ9hK51c5 #NeuroTwitter #COVID https://t.co/oTDDslV2Nw
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Mashup Score: 0Mutational Profile in 75 Patients With Anti–Myelin-Associated Glycoprotein Neuropathy - 1 year(s) ago
Background and Objectives Neuropathy with antibodies to myelin-associated glycoprotein (MAG) is the most common paraproteinemic IgM neuropathy. Recently, the mutational profile of the MYD88 and CXCR4 genes has been included in the diagnostic workup of IgM monoclonal gammopathies. The objective of our study was to assess the prevalence of MYD88 L265P and CXCR4 S338X gene variants in patients…
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Mutational Profile in 75 Patients With Anti–Myelin-Associated Glycoprotein Neuropathy: Clinical and Hematologic Therapy Response and Hints on New Therapeutic Targets https://t.co/ZOmb7TL3tl #NeuroTwitter https://t.co/DshJWM25DN
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Mashup Score: 1
Background and Objectives SARS-CoV-2 infection has been associated with a syndrome of long-term neurologic sequelae that is poorly characterized. We aimed to describe and characterize in-depth features of neurologic postacute sequelae of SARS-CoV-2 infection (neuro-PASC). Methods Between October 2020 and April 2021, 12 participants were seen at the NIH Clinical Center under an observational…
Categories: Latest Headlines, NeurologyTweet-
“Deep Phenotyping of Neurological Post-Acute Sequelae of SARS-CoV2 Infection” by Mina, Y., et al. Neurology-Neuroimmunology Neuroinflammation https://t.co/JaEUKNaetJ https://t.co/RyUyycJw0Q
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Mashup Score: 2Neurology - Neuroimmunology Neuroinflammation: 10 (3) - 1 year(s) ago
Research Articles Open Access Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy , Fumitaka Shimizu, Motoi Kuwahara, Yoichi Mizukami, Kenji Watanabe, Toshihiko Maeda, Yasuteru Sano, Yukio Takeshita, Michiaki Koga, Susumu Kusunoki, Takashi Kanda Open Access …
Categories: Latest Headlines, NeurologyTweet-
The May 2023 issue of Neurology: Neuroimmunology & Neuroinflammation is available online now! All articles are free to read: https://t.co/liqp9e5KUC #NeuroTwitter https://t.co/ZL5g9iDvp6
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Mashup Score: 17
Objective We report a case of biopsy-proven giant cell arteritis after an initial presentation of area postrema syndrome. Methods A 65-year-old man was evaluated using MRI, temporal artery biopsy, and ultrasound. Results The patient presented with refractory nausea, vomiting, and hiccups that caused weight loss without any other neurologic or clinical symptoms. His MRI scan 15 days later…
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This case demonstrates the importance of expanding the differential diagnosis in patients with area postrema syndrome and no other signs of #NMOSD. Learn more: https://t.co/1tmMqszDAP #NeuroTwitter https://t.co/XOYA7tihqg
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Mashup Score: 0Arterial Spin Labeling Changes Parallel Asymmetric Perisylvian and Perirolandic Symptoms in 3 Pediatric Cases of Anti-NMDAR Encephalitis - 1 year(s) ago
Background and Objectives Anti-NMDA receptor autoimmune encephalitis (NMDAR AE) is an autoantibody-mediated disorder characterized by seizures, neuropsychiatric symptoms, movement disorder, and focal neurologic deficits. Conventionally defined broadly as an inflammatory brain disease, the heterotopic localization is rarely discussed in children. Imaging findings are often nonspecific, and there…
Categories: Latest Headlines, NeurologyTweet-
Arterial Spin Labeling Changes Parallel Asymmetric Perisylvian and Perirolandic Symptoms in 3 Pediatric Cases of Anti-NMDAR Encephalitis: https://t.co/qgAJWXcMWO #NeuroTwitter https://t.co/UxDzbYiJyf
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According to this study, #MS relapses during pregnancy after #fingolimod cessation are common. Approximately 6% will retain clinically meaningful disability from these pregnancy-related, fingolimod cessation relapses 1 year postpartum. https://t.co/tB8Xy4SYTk https://t.co/Ad456JEP4T