• Mashup Score: 6
    Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD - 4 year(s) ago

    Intestinal epithelial glycosylation is influenced by host genetics, the environment and the gut microbiota. In this Review, Kudelka et al. describe the functions of epithelial glycans and discuss the role of epithelial glycosylation in Crohn’s disease and ulcerative colitis.

    Source: Nature Reviews Gastroenterology & Hepatology
    Categories: Gastroenterology, Latest Headlines
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      NatRevGastroHep

      Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD by Matthew R. Kudelka, Sean R. Stowell, Richard D. Cummings & Andrew S. Neish https://t.co/wMJ1qhEugH https://t.co/3mUVyq4iJO

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      NatRevGastroHep

      In our new Review, the authors examine downstream effects of altered #glycosylation in #IBD, including in mucin biology, glycan–lectin interactions, host–microorganism interactions & immune regulation, plus opportunities to target host #glycans in IBD. https://t.co/wMJ1qhEugH https://t.co/tMhmAxtTlm

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      NatRevGastroHep

      In this new Review, Andrew Neish et al. discuss the regulation of intestinal epithelial #glycosylation, altered epithelial glycosylation in #IBD & mechanisms for how these alterations contribute to disease #pathobiology incl. #GutMicrobiota interactions https://t.co/wMJ1qhEugH https://t.co/3YtjuDGRNH

  • Mashup Score: 0
    Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity - 4 year(s) ago

    Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a major breakthrough in cancer treatment. PD-1 is an inhibitory receptor expressed on the surface of activated T cells that dampens T-cell receptor (TCR)/CD28 signaling by engaging with its ligand PD-L1 expressed on cancer cells. Despite the clinical success…

    Source: Cancer Research
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CR_AACR

      Sun et al. study the regulatory mechanisms underlying #PD1 and show the functional significance of PD-1 #glycosylation which makes glycosylated PD-1 a potential target for #immunotherapy. @MDAndersonNews @ri_yao https://t.co/gM3SDgDZ2N https://t.co/j5LAtLS7uY

  • Mashup Score: 1
    Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity - 4 year(s) ago

    Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a major breakthrough in cancer treatment. PD-1 is an inhibitory receptor expressed on the surface of activated T cells that dampens T-cell receptor (TCR)/CD28 signaling by engaging with its ligand PD-L1 expressed on cancer cells. Despite the clinical success…

    Source: Cancer Research
    Categories: Hem/Onc News and Journals, Latest Headlines
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    • Profile photo of CR_AACR
      CR_AACR

      Sun et al. study the regulatory mechanisms underlying #PD1 and show the functional significance of PD-1 #glycosylation which makes glycosylated PD-1 a potential target for #immunotherapy. @MDAndersonNews @ri_yao https://t.co/L9xESeVjEe https://t.co/XJBDZuysrB

  • Mashup Score: 3
    Glycosylation in health and disease - 4 year(s) ago

    Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’.

    Source: Nature Reviews Nephrology
    Categories: Nephrology
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      NatRevNeph

      Aberrant O- #glycosylation in #IgA nephropathy. https://t.co/F3RIAqnD9h https://t.co/SgHfrXr0Va