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Mashup Score: 22
Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral heterogeneity and tumor evolution. We utilized 3D neuron…
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 5Pyruvate kinase M2 (PKM-2) expression and prognostic significance in glioblastoma patients - 5 month(s) ago
Journal of Neuro-Oncology – Pyruvate kinase M2 (PKM2) is a key enzyme that catalyzes the irreversible and final step of glycolysis. It is closely associated with cancer development and progression….
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 35
Journal of Neuro-Oncology – The prognosis of patients ≥ 75 years suffering from glioblastoma is poor. Novel therapies are usually reserved for patients ≤ 70…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 4
A first-in-human trial of an oncolytic virus shows that it is safe and seems to stimulate anti-tumour immune responses.
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 4
A first-in-human trial of an oncolytic virus shows that it is safe and seems to stimulate anti-tumour immune responses.
Source: www.nature.comCategories: General Medicine News, Expert PicksTweet
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Mashup Score: 3CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia‑induced invasion and therapeutic resistance - 7 month(s) ago
Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (EGFRvIII). The amplification of the CHCHD2 gene was found to be associated with a decreased patient overall and progression‑free survival. The CHCHD2 mRNA levels were increased in high‑vs. low‑grade glioma, IDH‑wt GBMs, and in tumor vs. non‑tumor tissue. Additionally, CHCHD2 protein expression was greatest in invasive, EGFRvIII‑expressing patient‑derived samples. The CRISPR‑Cas9‑mediated knockout of CHCHD2 in EGFRvIII‑expressing U87 cells resulted in an altered m
Source: www.spandidos-publications.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1
The Australian scientist sees his illness not as a death sentence, but an opportunity to transform treatment for a stubbornly intractable form of cancer.
Source: www.bnnbloomberg.caCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2
Sex-biased T-cell exhaustion in glioblastoma is, in part, regulated by T cell–intrinsic factors, such as the X chromosome inactivation escape gene Kdm6a, which highlights the potential for a precision therapy approach based on patient biologic sex.
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0The EU Funded Project LEGATO Officially Started - 7 month(s) ago
We are delighted to announce the official start of LEGATO, a pragmatic phase III clinical trial focusing on recurrent Glioblastoma.
Source: www.eortc.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 9Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma - 7 month(s) ago
scRNA-seq and live-imaging in zebrafish avatars were used to study the complex and dynamic interplay between GBM tumor cells and GAMs, and provide fresh perspectives and opportunities for discovering…
Source: www.embopress.orgCategories: General Medicine News, Latest HeadlinesTweet
New 3D spatial approach reveals interactive view of #glioblastoma and therapeutic targets @northwesternu @CellCellPress https://t.co/eTS2dKGAT2 https://t.co/P2HG6Sz1DI