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Mashup Score: 29Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists - 1 year(s) ago
Aims Interobserver variability in the assessment of gastric neoplasia biopsies between most Western and Eastern (predominantly represented by Japanese in the literature) pathologists has been documented. It is unknown if such variability exists between the US and Korean pathologists in the current era. Methods Ten gastrointestinal (GI) pathologists from the USA (n=5) and South Korea (n=5) evaluated 100 scanned images of gastric (n=50) and colorectal (n=50) neoplasia biopsies and answered multiple questionnaires. Consensus was defined as the answer chosen by the majority. Cohen’s (κc) and Fleiss’ kappa (κf) values were calculated between the consensus of the two groups and among the raters, respectively. Results Both groups reached a consensus in the majority of cases (74%–100%) with slight to perfect intergroup (κc=0.049–1.000) and no to substantial intragroup (κf=−0.083 to 0.660) agreements. For gastric neoplasia, Korean pathologists relied heavily on cytoarchitectural atypia, whereas
Source: jcp.bmj.comCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 12Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays - 1 year(s) ago
Aim Pancreatic cyst fluid carcinoembryonic antigen (CEA) is a pivotal test in the diagnosis and management of neoplastic mucinous cysts (NMC) of the pancreas. Cyst fluid CEA levels of 192 ng/mL have been widely used to identify NMC. However, CEA values are unique to and significantly differ between individual assays with various optimal cutoffs reported in the literature for NMC. Here, we investigate the optimal CEA cut-off value of pancreatic cysts from two different assays to identify differences in thresholds. Methods Pancreatic cyst fluid CEA levels, CEA assay platform (Beckman Dxl (BD) or Siemens Centaur XP (SC)), and clinical/pathological information were retrospectively collected. Cases were categorised into either NMC or non-NMC. Optimal CEA cut-off values were calculated via a receiver operator characteristic curve. Cut-off values were then identified separately by assay platform. Results In total, 149 pancreatic cystic lesions with concurrent CEA values (SC: n=47; BD: n=102)
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
Identifies at a transected margin of the pancreas by one of our Editors! Cancer anyone? #Gipath Some recently published papers - pancreas👇 https://t.co/03qoQkbQax https://t.co/QnLNGGQEz3 https://t.co/dd2CVilIJd https://t.co/YX1v8s5ZEw PS right is an AI-generated version😀 https://t.co/hcUWDJwaHV
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Mashup Score: 29Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists - 1 year(s) ago
Aims Interobserver variability in the assessment of gastric neoplasia biopsies between most Western and Eastern (predominantly represented by Japanese in the literature) pathologists has been documented. It is unknown if such variability exists between the US and Korean pathologists in the current era. Methods Ten gastrointestinal (GI) pathologists from the USA (n=5) and South Korea (n=5) evaluated 100 scanned images of gastric (n=50) and colorectal (n=50) neoplasia biopsies and answered multiple questionnaires. Consensus was defined as the answer chosen by the majority. Cohen’s (κc) and Fleiss’ kappa (κf) values were calculated between the consensus of the two groups and among the raters, respectively. Results Both groups reached a consensus in the majority of cases (74%–100%) with slight to perfect intergroup (κc=0.049–1.000) and no to substantial intragroup (κf=−0.083 to 0.660) agreements. For gastric neoplasia, Korean pathologists relied heavily on cytoarchitectural atypia, whereas
Source: jcp.bmj.comCategories: General Medicine News, General Journals & SocietTweet-
K-drama time😀 Test your skills with a group of US and Korean pathologists! Gastric biopsies. High-grade dysplasia or adenocarcinoma! #GIpath @stephen_lagana https://t.co/547jrdTdgE https://t.co/RVDbKWIuPn
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Mashup Score: 3Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists - 1 year(s) ago
Aims Interobserver variability in the assessment of gastric neoplasia biopsies between most Western and Eastern (predominantly represented by Japanese in the literature) pathologists has been documented. It is unknown if such variability exists between the US and Korean pathologists in the current era. Methods Ten gastrointestinal (GI) pathologists from the USA (n=5) and South Korea (n=5) evaluated 100 scanned images of gastric (n=50) and colorectal (n=50) neoplasia biopsies and answered multiple questionnaires. Consensus was defined as the answer chosen by the majority. Cohen’s (κc) and Fleiss’ kappa (κf) values were calculated between the consensus of the two groups and among the raters, respectively. Results Both groups reached a consensus in the majority of cases (74%–100%) with slight to perfect intergroup (κc=0.049–1.000) and no to substantial intragroup (κf=−0.083 to 0.660) agreements. For gastric neoplasia, Korean pathologists relied heavily on cytoarchitectural atypia, whereas
Source: jcp.bmj.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
K-drama time😀 Test your skills with a group of US and Korean pathologists! Gastric biopsies. High-grade dysplasia or adenocarcinoma! #GIpath @stephen_lagana https://t.co/547jrdTL6c https://t.co/qzT8mXfoZo
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Mashup Score: 8Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa - 1 year(s) ago
Aims Studying crypt branching in ulcerative colitis (UC) and in infectious colitis (IC), we detected previously unreported crypt-associated anomalies (CAAs). The objective was to describe, illustrate and assess the frequency of CAAs in inflamed colon mucosa in patients with UC and IC. Methods Sections from 100 consecutive biopsies with UC, in 50 with IC and in 27 with UC in remission (UCR) were…
Source: Journal of Clinical PathologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
👇🔥#OriginalResearch #OpenAccess🔓 "Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa" by Rubio et al. https://t.co/2gUhITjfrQ #GIpath https://t.co/uX4rrOCp9Q https://t.co/qH620fFVcd
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Mashup Score: 1Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis - Nature Medicine - 1 year(s) ago
Multiomics analysis of right colon tissues identifies a distinct immune gene signature associated with greater risk of and shorter time to dysplasia in patients with primary sclerosing cholangitis, but not in patients with inflammatory bowel disease.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
Really enjoyed this #OpenAccess @NatureMedicine paper by @BanaJabri @LB_Barreiro @UChicago with my #GIPath 🎩 on: Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis https://t.co/memau71W7K
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Mashup Score: 11My approach to bowel ischaemia - 2 year(s) ago
Resections of ischaemic bowel are one of the most common pathology specimens yet are often viewed as unappealing and diagnostically unrewarding. This article serves to dispel both misconceptions. It also provides guidance on how clinical information, macroscopic handling and microscopic assessment—and especially the interlinking of all three—can maximise the diagnostic yield of these specimens….
Source: Journal of Clinical PathologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
“My approach to bowel ischemia” Review by Dr. Newton Wong on optimizing diagnosis through clinical information, macroscopic handling, & microscopic assessment. Discussing causes of intestinal ischaemia, artifacts, & mimics of ischaemia. #gipath https://t.co/aFBt6uPU3Q https://t.co/Kmh8gIlqpa
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Mashup Score: 1Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond - 2 year(s) ago
The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-dependent mechanisms to respond to injury. Superficial injury heals via surface cells with histopathologic changes like foveolar hyperplasia. Deeper, usually chronic, injury/inflammation, most frequently induced by the carcinogenic bacteria Helicobacter pylori, elicits glandular histopathologic alterations,…
Source: GastroenterologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Great talk on early GI neoplasia & paligenosis by @millsjc67 at our @theNCI consortium meeting this morning. Primer on paligenosis below: https://t.co/0x3IUZQP0X One fascinating piece of #GIPath history - intestinal metaplasia in the gastric mucosa in 1897! #PathTwitter https://t.co/s56kcfqzja
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Mashup Score: 4Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors - 2 year(s) ago
Abstract. Prior small reports have postulated a link between gastrointestinal polyposis and childhood and young adulthood cancer (CYAC) treatment (therapy-associated polyposis; TAP), but this remains a poorly understood phenomenon. The aim of this study was to describe the phenotypic spectrum of TAP in a multi-institutional cohort. TAP cases were identified from eight high-risk cancer centers….
Categories: Hem/Oncs, Latest HeadlinesTweet-
I had no idea about this entity! #OpenAccess in @CAPR_AACR: A Multi-Institutional Cohort of Therapy-Associated Polyposis (TAP) in Childhood and Young Adulthood Cancer Survivors https://t.co/R4Jyq68FIF Thanks @MattYurgelun @SapnaSyngal & colleagues! #AYACancer #GIPath
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Mashup Score: 0KiKoXP | Helicobacter pylori antibody positivity in stroma? - 2 year(s) ago
Sometimes you will perform a Helicobacter IHC on your sample and see antibody positive “clumps” in the stroma, within phagocytic cells.
Source: kikoxp.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Friday #GIPath musings… I am not aware if this has been reported, but would love to hear if other #pathologists have seen it? Helicobacter pylori IHC antibody positive “clumps” in the stroma. In this case, there was marked infection in another part. 🔬 https://t.co/CnN1Lkodou
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K-drama time😀 Test your skills with a group of US and Korean pathologists! Gastric biopsies. High-grade dysplasia or adenocarcinoma! #GIpath @stephen_lagana https://t.co/547jrdTdgE https://t.co/RVDbKWIuPn