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Mashup Score: 3Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer - 4 year(s) ago
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single CAF-S1 fibroblasts from breast cancer. We validate the five most abundant clusters by flow cytometry and in silico analyses in other cancer…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer - 4 year(s) ago
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single CAF-S1 fibroblasts from breast cancer. We validate the five most abundant clusters by flow cytometry and in silico analyses in other cancer…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the September issue: #SingleCell analysis reveals #fibroblast clusters linked to #immunotherapy resistance in #cancer. @institut_curie @FatimaMechta https://t.co/vUGXFVZSzs https://t.co/a5T0Pmsr9E
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Mashup Score: 2
Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, especially ceramides. When melanoma cells are exposed to the aged fibroblast lipid secretome, or...
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
From the September issue: Changes in aged #fibroblast lipid #metabolism induce age-dependent #melanoma cell resistance to #TargetedTherapy via the fatty acid transporter FATP2. #Aging @gretchen_alicea @AshaniTW @JHSPHBMB https://t.co/NqOvrC80ao https://t.co/8TZF8GYhDb
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Mashup Score: 0Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties - 4 year(s) ago
Although fibrotic stroma forms an integral component of pancreatic diseases, whether fibroblasts programmed by different types of pancreatic diseases are phenotypically distinct remains unknown. Here, we show that fibroblasts isolated from patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary tumors, and adjacent normal (NA) tissue ( N = 34) have distinct…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Different pancreatic pathologies have disease-specific #fibroblast programming, Barrera et al report. This finding has consequences for therapeutic targeting and the use of fibroblasts in research. @LivUni @LN_Barrera https://t.co/YilkZsz2TV https://t.co/BYpEQuqpYq
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Mashup Score: 0Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties - 4 year(s) ago
Although fibrotic stroma forms an integral component of pancreatic diseases, whether fibroblasts programmed by different types of pancreatic diseases are phenotypically distinct remains unknown. Here we show that fibroblasts isolated from patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary tumors (PAT), and adjacent normal (NA) tissue (N=34) have…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Different pancreatic pathologies have disease-specific #fibroblast programming, Barrera et al. report. This finding has consequences for therapeutic targeting and the use of fibroblasts in research. https://t.co/qwDnjw2qDg @LivUni @LN_Barrera https://t.co/lSZp4BpCdr
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Mashup Score: 1
Older melanoma patients (>50 years old) have poorer prognoses and response rates to targeted therapy compared to young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, especially ceramides. When melanoma cells are exposed to the aged fibroblast lipid secretome, or co-cultured...
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Just published #OnlineFirst! Changes in aged #fibroblast lipid #metabolism induce age-dependent #melanoma cell resistance to #TargetedTherapy via the fatty acid transporter FATP2 #Aging @gretchen_alicea @AshaniTW @JHSPHBMB https://t.co/dQuZPiDkUX
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Mashup Score: 0Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties - 4 year(s) ago
Although fibrotic stroma forms an integral component of pancreatic diseases, whether fibroblasts programmed by different types of pancreatic diseases are phenotypically distinct remains unknown. Here we show that fibroblasts isolated from patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary tumors (PAT), and adjacent normal (NA) tissue (N=34) have…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Different pancreatic pathologies have disease-specific #fibroblast programming, Barrera et al. report. This finding has consequences for therapeutic targeting and the use of fibroblasts in research. @LivUni @LN_Barrera https://t.co/A7hPE9MME3 https://t.co/c7zwiZqC4b
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Mashup Score: 3Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer - 4 year(s) ago
A subset of Cancer-Associated Fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers (BC), but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19000 single CAF-S1 fibroblasts from BC. We validate the 5 most abundant clusters by flow cytometry and in silico analyses in other cancer types,…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Just published #OnlineFirst! #SingleCell analysis reveals #fibroblast clusters linked to #immunotherapy resistance in #cancer. @institut_curie @FatimaMechta https://t.co/mYDb1W97SM https://t.co/U1pAO9aCZH
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Mashup Score: 2Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy | Circulation Research - 4 year(s) ago
Rationale: Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to contribute to the substrate of atrial fibrillation. Objective: Here, we examined if the epicardium t…
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Chronic arterial remodeling may be due to epicardium located progenitor cells. Learn more about #fibroblast & #adipocyte progenitors and #cardiomyopathy in a study by @SuffeeM et al from @HatemStephane group. https://t.co/r5Sg1fyYUF https://t.co/rd98oMrx48
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Mashup Score: 2Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy | Circulation Research - 4 year(s) ago
Rationale: Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to contribute to the substrate of atrial fibrillation. Objective: Here, we examined if the epicardium t…
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Chronic arterial remodeling may be due to epicardium located progenitor cells. Learn more about #fibroblast & #adipocyte progenitors and #cardiomyopathy in a study by @SuffeeM et al from @HatemStephane group. https://t.co/r5Sg1fyYUF https://t.co/rd98oMrx48
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#SingleCell analysis reveals #fibroblast clusters linked to #immunotherapy resistance in #cancer. @institut_curie @FatimaMechta #AACRHET20 https://t.co/4kglJmktZY https://t.co/1ylG6Zvwlh