• Mashup Score: 8
    The biology of ependymomas and emerging novel therapies - Nature Reviews Cancer - 2 year(s) ago

    Our understanding of ependymomas, which are rare tumours of the central nervous system, has increased substantially over the past 10 years. This Review discusses important biological features of ependymoma as well as key oncogenes, tumour suppressors and epigenetic changes that could potentially be exploited to improve therapy.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      In the April issue of @NatureRevCancer | Review, The biology of #ependymoma and emerging novel therapies, by AH Saleh, N Samuel (..) and @DrFehlings https://t.co/ssYmuaHBi5 @natrescancer https://t.co/1fL0qRWAq0

  • Mashup Score: 3
    The biology of ependymomas and emerging novel therapies - Nature Reviews Cancer - 2 year(s) ago

    Our understanding of ependymomas, which are rare tumours of the central nervous system, has increased substantially over the past 10 years. This Review discusses important biological features of ependymoma as well as key oncogenes, tumour suppressors and epigenetic changes that could potentially be exploited to improve therapy.

    Source: Nature
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      NEW Review! AH Saleh, N Samuel (..) and @DrFehlings discusses important biological features of #ependymoma as well as key oncogenes, tumour suppressors and epigenetic changes that could potentially be exploited to improve therapy. https://t.co/ssYmuaHBi5 @natrescancer https://t.co/4ezFq7usin

  • Mashup Score: 5
    ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors - 3 year(s) ago

    ZFTA ( C11orf95 )—a gene of unknown function—partners with a variety of transcriptional coactivators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing therapies that inhibit these fusion proteins. Here, using a combination of transcriptomics, chromatin immunoprecipitation sequencing, and proteomics, we…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CD_AACR

      From the September issue: ZFTA-translocations constitute #ependymoma chromatin remodeling and transcription factors. https://t.co/pUg5Ufpp9E. @Gilbertson_Lab @CRUKCamNeuroOnc @CRUKCamPaeds @Cambridge_Uni https://t.co/5rTwrUoQwO

  • Mashup Score: 2
    ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma - 3 year(s) ago

    More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion (formerly C11orf95–RELA ). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcriptomic mapping was performed on IUE-driven ZRfus tumors by CUT&RUN, chromatin immunoprecipitation…

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CD_AACR

      From the September issue: ZFTA-RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial #ependymoma. https://t.co/m7CcRfrgKl. @AmirArabzade @emacalate @bendeneen @TexasChildrens https://t.co/uDf6ZpzRZ5

  • Mashup Score: 0
    Help raise money for Enzo’s medical bills, organized by Brian Fish - 3 year(s) ago

    This is my little buddy Enzo Gentile. He just celebrated his Fifth Birthday on Fe… Brian Fish needs your support for Help raise money for Enzo’s medical bills

    Source: gofundme.com
    Categories: Hem/Oncs, Latest Headlines
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      DrMajeski

      #ChildhoodCancer extends far beyond work & into our own circles, so I’m sharing this on behalf of my buddy Enzo & his family as he goes to NYC to give #protontherapy its best shot at 🪓 #ependymoma. #PHO #PHOdocs #pediatriccancer #braintumor #MedTwitter https://t.co/hUwscT18Gx

  • Mashup Score: 10
    Hemangioblastomas and Other Uncommon Intramedullary Tumors - 3 year(s) ago

    Astrocytoma and ependymoma make up 90% of intramedullary tumors between them. However, a host of less common tumors form the remaining 10%: these include hemangioblastomas, subependymomas, gangliogliomas and other neuronal variants, metastases from extraneural cancers, and a host of other lesions that typically occur intracranially but which present on rare occasions in the intramedullary…

    Source: Journal of Neuro-Oncology
    Categories: Hem/Onc News and Journals, Latest Headlines
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      JNeurooncol

      #Astrocytoma and #ependymoma make up 90% of spinal cord tumors between them, less common #hemangioblastomas, #subependymomas, #gangliogliomas and other neuronal variants, metastases from extraneural cancers - this review discusses these @MDAndersonNews https://t.co/SND35Vwppo https://t.co/NouXAxm7EH

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