-
Mashup Score: 2Hematological adverse events in the management of glioblastoma - Journal of Neuro-Oncology - 2 year(s) ago
Background Hematological adverse events (HAEs) are common during treatment for glioblastoma (GBM), usually associated with temozolomide (TMZ). Their clinical value is uncertain, as few investigations have focused on outcomes for HAEs during GBM treatment. Methods We combined data from two randomized clinical trials, RTOG 0525 and RTOG 0825, to analyze HAEs during treatment for GBM. We…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
-
Mashup Score: 4Discordances in ER, PR, and HER2 between primary breast cancer and brain metastasis - Journal of Neuro-Oncology - 2 year(s) ago
When distant metastases are discovered, it is important to determine receptor profiles of these lesions through histologic examination. However, brain metastasis sites are difficult to reach to be routinely biopsied. The purpose of this study was to determine expression profiles of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in breast…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read about discordances in ER, PR, and HER2 between primary breast cancer and brain metastasis @NSTumorSection #mets #cancer #genomics https://t.co/3QP84tGQq1 https://t.co/uDLBjeGt0Q
-
-
Mashup Score: 1Reforming support systems of newly diagnosed brain cancer patients: a systematic review - Journal of Neuro-Oncology - 2 year(s) ago
Purpose Despite the increasing incidence of currently incurable brain cancer, limited resources are placed in patients’ support systems, with reactive utilisation late in the disease course, when physical and psychological symptoms have peaked. Based on patient-derived data and emphasis on service improvement, this review investigated the structure and efficacy of the support methods of newly…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Establishing a support system for patients with brain cancer is critical in maximizing care quality. Check out this new article from @UCL outlining a four-step plan for healthcare services to provide effective support for #brain #tumor patients. https://t.co/WRUHcUOcjb https://t.co/HYgaqMumFp
-
-
Mashup Score: 0Genetic modulation of longitudinal change in neurocognitive function among adult glioma patients - Journal of Neuro-Oncology - 2 year(s) ago
Purpose Impaired neurocognitive function (NCF) is extremely common in patients with higher grade primary brain tumor. We previously reported evidence of genetic variants associated with NCF in glioma patients prior to treatment. However, little is known about the effect of genetic variants on NCF decline after adjuvant therapy. Methods Patients (N = 102) completed longitudinal NCF assessments…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New this week in JNO: Wefel et al show #polymorphisms associated with #cognition and #DNArepair are predictive of post-treatment cognitive impairment in #glioblastoma. https://t.co/kSy4pUqs4v https://t.co/6ZGVWEBgMz
-
-
Mashup Score: 5
Introduction Glioblastoma multiforme (GBM) constitutes one of the deadliest tumors to afflict humans, although it is still considered an orphan disease. Despite testing multiple new and innovative therapies in ongoing clinical trials, the median survival for this type of malignancy is less than two years after initial diagnosis, regardless of therapy. One class of promising new therapies are…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Check out this introduction to the field of T-cell engineering using #CART to treat #GBM, which describe the obstacles that may need to be addressed in order to significantly delay the relentless growth of #GBM @caseccc @cwru @UHhospitals https://t.co/wodLEQHah0 https://t.co/72D6tgg6ww
-
-
Mashup Score: 0
Introduction Glioblastoma multiforme (GBM) constitutes one of the deadliest tumors to afflict humans, although it is still considered an orphan disease. Despite testing multiple new and innovative therapies in ongoing clinical trials, the median survival for this type of malignancy is less than two years after initial diagnosis, regardless of therapy. One class of promising new therapies are…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Using chimeric antigen receptor T-cell therapy to fight glioblastoma multiforme: past, present and future developme… https://t.co/g8A7FnyjM4 #CART #bmtsm #CARTcell #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy #Gene #Genetherapy @ASTCT
-
-
Mashup Score: 1Cognitive functioning and functional brain networks in postoperative WHO grade I meningioma patients - Journal of Neuro-Oncology - 2 year(s) ago
Introduction Meningioma patients often have subtle cognitive deficits that might be attributed to the tumor itself, to surgical treatment, or to the occurrence of seizures and their treatment. Magnetoencephalography (MEG) analysis of resting-state functional networks (RSNs) could help to understand the neurophysiological basis of cognitive impairment in these patients. We explored the correlation…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Cognitive functioning and functional brain networks in postoperative WHO grade I meningioma patients @NSTumorSection @NASBSorg #cancer #brain #skull https://t.co/iKhkWTI8s6 https://t.co/a5lRqR3sQ6
-
-
Mashup Score: 4
Abstract The following questions and recommendations are pertinent to the following: Target population These recommendations apply to adults with progressive GBM who have undergone standard primary treatment with surgery and/or chemoradiation. Question 1 In adults with progressive glioblastoma is the use of bevacizumab as monotherapy superior to standard salvage cytotoxic chemotherapy as measured…
Source: Journal of Neuro-OncologyCategories: Hematologists1, Latest HeadlinesTweet-
Evidence-based guidelines update on the role of targeted therapies and immunotherapies in the management of progressive glioblastoma https://t.co/aF6FrrZa56
-
-
Mashup Score: 0Increased proliferation is associated with CNS invasion in meningiomas - Journal of Neuro-Oncology - 2 year(s) ago
Introduction Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to elucidate whether histopathological evidence of…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
A new study from @uni_tue shows that Ki67 expression in #meningiomas is associated with histopathological detection of CNS invasion. This suggests that meningiomas with infiltrative growth have higher rates of proliferation. #JNO #BTSM Read more at: https://t.co/q108xyJyBL https://t.co/KU188IyOO2
-
-
Mashup Score: 1
Journal of Neuro-Oncology –
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Not all that is middle is embryologic midline: Paoli et al show K27M mutations are extremely rare in CC-based glioblastoma. #H3K27M #DMG. @NSTumorSection #JNO https://t.co/JH0GaqvA4w https://t.co/terehOQmze
-
Hematologic adverse events (HAEs) may be associated with prolonged PFS and OS in GBM patients, particularly during adjuvant therapy. #GBM #hematology #PFS #oncology https://t.co/Gs2Hi5BJfU https://t.co/oI6m0yfhCR