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Mashup Score: 2Clinical characteristics and long-term surgical outcome of spinal myxopapillary ependymoma: a French cohort of 101 patients - 3 year(s) ago
Purpose Myxopapillary ependymoma (MPE) is the most frequent tumor affecting the medullary conus. The surgical therapeutic management is still debated and only few studies have focused on the postoperative clinical outcome of patients. This study aimed to demonstrate long-term postoperative outcome and to assess the predictive factors of recurrence as well as the clinical evolution of these…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas - 3 year(s) ago
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA-RELA or YAP1-involving fusions and fusion-negative subependymoma. However, occasionally supratentorial ependymomas cannot be readily assigned to any of these groups due to lack of detection of a typical fusion and/or ambiguous DNA methylation-based classification. An unbiased approach with a cohort of unprecedented size…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @Pajtler_Lab: https://t.co/cjCtNf1BCt Check out our latest paper on supratentorial #ependymoma, published in @CD_AACR! This was a great…
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Mashup Score: 3Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas - 3 year(s) ago
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA-RELA or YAP1-involving fusions and fusion-negative subependymoma. However, occasionally supratentorial ependymomas cannot be readily assigned to any of these groups due to lack of detection of a typical fusion and/or ambiguous DNA methylation-based classification. An unbiased approach with a cohort of unprecedented size…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Recently published #OnlineFirst: Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial #ependymoma. @TuyuZheng @DavidRGhasemi1 @KiTZ_HD @DKFZ https://t.co/geSaTVnFml https://t.co/mBuOTwHlSH
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Mashup Score: 1ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma - 3 year(s) ago
Over 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcriptomic mapping was performed on IUE driven ZRfus tumors by CUT&RUN, ChIP, ATAC, and RNA sequencing and…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Recently published #OnlineFirst: ZFTA-RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial. #ependymoma @AmirArabzade @emacalate @bendeneen @TexasChildrens @bcmhouston https://t.co/X7HszfATQy https://t.co/aDippspvA5
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Mashup Score: 0ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors - 3 year(s) ago
ZFTA (C11orf95)-a gene of unknown function-partners with a variety of transcriptional co-activators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing therapies that inhibit these fusion proteins. Here, using a combination of transcriptomics, chromatin immunoprecipitation-sequencing, and proteomics, we…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Recently published #OnlineFirst: ZFTA-translocations constitute #ependymoma chromatin remodeling and transcription factors. @Gilbertson_Lab @CRUKCamNeuroOnc @CRUKCamPaeds @Cambridge_Uni https://t.co/E6gmC650pg https://t.co/MwgSi5lPx3
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Mashup Score: 0
pressure. Many commonly used pain medications are associated with deleterious side effects such as bleeding and excessive sedation. These effects prevent lucidity for interactions, confound neurologic examination. A lidocaine infusion resulted in significant pain relief without these negative side effects. We discuss lidocaine infusion use and considerations for children suffering from…
Source: LWWCategories: Anesthesiology, Latest HeadlinesTweet-
An 8 yo with a history of supratentorial #ependymoma presented with worsening #headache, nausea, and vomiting. A #lidocaine infusion was eventually titrated to 2 mg/h with therapeutic lidocaine plasma levels #PainManagement #PalliativeCare @PediAnesthesia https://t.co/Xanx6Ne2Dk https://t.co/jFTuU2RbG0
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Mashup Score: 0Cysts associated with intramedullary ependymomas of the spinal cord: clinical, MRI and oncological features - 4 year(s) ago
Few published articles have explicitly focused on cysts associated with intramedullary (IM) ependymomas. The objective was to assess the clinical, MRI, and oncological results of patients operated for an IM ependymoma associated with a cystic portion. During the study period, 23 IM tumors resected were cystic ependymomas. The modified McCormick scale was used to assess the neurological function…
Source: Journal of Neuro-OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Intramedullary ependymomas often present with tumor-associated cysts. Dauleac et al, show that cyst persistence/recurrence may occur with or without tumor recurrence. #btsm #ependymoma #nsgy https://t.co/Vr0RBiAXWO https://t.co/NNb4MmqOK5
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Mashup Score: 0
Posterior fossa A (PFA) ependymomas required a hypoxic environment to maintain their epigenomes.
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#ResearchWatch Hypoxia-induced epigenetic dysregulation promotes infantile #ependymoma. @AntonyKM @sachin_kumar14 @SickKidsNews #BrainCancer #Epigenetics https://t.co/vOLwOwkEJE https://t.co/XRWK040ehK
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Do you have a patient with a spinal myxopapillary #ependymoma? Check out this recent study from France to learn about the clinical characteristics and post-op outcomes for this pathology. @Sorbonne_Univ_ @HopitalFoch @InstitutCochin https://t.co/zjJxszuZee https://t.co/l8MLORXqLQ