• Mashup Score: 0
    Patient Selection for Downstaging of Hepatocellular Carcinoma Prior to Liver Transplantation—Adjusting the Odds? - 2 year(s) ago

    Background and Aims: Morphometric features such as the Milan criteria serve as standard criteria for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Since it has been recognized that these criteria are too restrictive and do not adequately display the tumor biology, additional selection parameters are emerging.Methods: Concise review of the current literature on…

    Source: Frontiers
    Categories: Latest Headlines, Transplantation
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      Transpl_Int

      In summary, an available single marker of measuring the risk of tumor recurrence is still far away. Tumor biology has to be assessed by tumor burden, AFP levels, and response to therapy, including the use of PET and/or tumor biopsy in selected cases. https://t.co/uvZiAZS53E 10/10 https://t.co/nqPeQbM4EW

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      Transpl_Int

      It has been postulated that poorly differentiated tumors can be identified by means of PET positivity, confirming that morphometric criteria alone might not be ideal discriminators in MC-out patients. https://t.co/uvZiAZS53E 9/10

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      Transpl_Int

      AFP might help to identify patients with a high drop-out risk during downstaging, and on the other hand, an initial AFP <20 ng/ml might be predictive of a good response to downstaging therapies and a low recurrence rate after #LiverTransplant. https://t.co/uvZiAZS53E 8/10 https://t.co/SZfzjbM78i

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      Transpl_Int

      Patients within the MC might not need a tumor biopsy, due to the relatively low risk of G3 tumors, and the acceptable risk of mVI. However, in these patients, the very low risk has to be weighed against the potential benefit of tumor biopsy https://t.co/uvZiAZS53E 7/10 https://t.co/OcvAsfrrdb

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      Transpl_Int

      The justification for #downstaging and an acceptable drop-out rate needs to be seen and determined in light of the efficacy of alternative treatments, organ availability, and a patient’s attitude toward a concept holding a limited chance of success. https://t.co/uvZiAZS53E 6/10 https://t.co/YizOAz5lH1

    • Profile photo of Transpl_Int
      Transpl_Int

      While MC selection criteria were intended from an ITT perspective, they are too unspecific as a surrogate for tumor biology, withholding a life-saving procedure from a group of patients with large/multilocular, but biologically favorable HCCs https://t.co/uvZiAZS53E 5/10 https://t.co/xqtraowPCD

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      Transpl_Int

      This results in different grades of differentiation, even within the same lesion, highlighting a critical unmet need for reliable invasive or non-invasive #preoperative #detection of microvascular invasion and/or tumor biology. https://t.co/uvZiAZS53E 4/10 https://t.co/Sm8kCcyV4w

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      Transpl_Int

      Based on transcriptomic profiling, HCC subclassification interlinks dysregulation of signaling pathways with genetic alterations, histological subtypes, and prognosis, underlying the molecular heterogeneity of HCC. https://t.co/uvZiAZS53E 3/10

    • Profile photo of Transpl_Int
      Transpl_Int

      With advances in the understanding of #HCC biology, #Milan #criteria appear too restrictive, since a significant proportion of MC-out patients are curable undergoing #LiverTransplant https://t.co/uvZiAZSCTc 2/10

  • Mashup Score: 3
    The future of early cancer detection - Nature Medicine - 2 year(s) ago

    Technological advances are producing exquisitely sensitive cancer detection tests. This Review discusses who should be tested, and how—and looks to the future of personalized, risk-based cancer screening.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Early #cancer #detection: advances in sensors, contrast agents, molecular methods, & artificial intelligence helping detect cancer-specific signals in real time. https://t.co/pASrxDGhoj https://t.co/W2HHk7L5be

  • Mashup Score: 14
    Synthetic biomarkers: a twenty-first century path to early cancer detection - Nature Reviews Cancer - 2 year(s) ago

    Synthetic biomarkers are an emerging class of diagnostics that amplify disease signals for sensitive and specific detection of early-stage cancers. This Review discusses the rationale and design of biofluid-based synthetic biomarkers as well as translational challenges and future directions.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      jsoriamd

      Enzymatic, small- molecule, DNA-based, cell-based sensors can enhance early #cancer #detection. Each technology senses dysregulated activity associated with TME. These approaches lower the limit of detection below clinical thresholds https://t.co/oZY2qBNLcS https://t.co/Q8F7vuqDpj

  • Mashup Score: 3
    Q&A: Ray DuBois on Screening, Early Detection - 2 year(s) ago

    Raymond DuBois, MD, PhD, director of the Medical University of South Carolina’s Hollings Cancer Center in Charleston, discusses cancer screening and the importance of increasing access to screening among economically disadvantaged people. He also offers thoughts on developing a pan-cancer blood test using circulating tumor DNA to aid in cancer detection.

    Source: Cancer Discovery
    Categories: Hem/Onc News and Journals, Latest Headlines
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      CD_AACR

      RT @Rndubois: Q&A on #cancer #screening and early #detection in Cancer Discovery @CD_AACR @muschollings: https://t.co/OIspAJa1Gj

  • Mashup Score: 1
    Goal should be ‘prevention, not just early detection’ when it comes to breast cancer - 2 year(s) ago

    A comprehensive approach to screening for breast cancer and working with patients to reduce their lifestyle risks can save more lives, Lisa Larkin, MD, FACP, NCMP, IF, said during the NAMS Annual Meeting. “Despite having very robust screening in our country with women getting annual mammography at a rate that’s higher than other developed countries, mortality for breast cancer in the

    Source: www.healio.com
    Categories: Cardiologists, Latest Headlines
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    • Profile photo of rblument1
      rblument1

      RT @Rndubois: Goal should be ‘#prevention, not just #early #detection’ when it comes to #breast #cancer https://t.co/OoTezsY5MP

  • Mashup Score: 1
    Detecting cancer with a simple blood draw could soon be a reality - 2 year(s) ago

    For decades, scientists have been working on ways to screen for cancers using a simple blood draw rather than a painful biopsy or invasive test.

    Source: ABC News
    Categories: Latest Headlines, Oncologists2
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      pashtoonkasi

      #News 📺 🗞 Detecting #cancer with a simple🩸blood draw could soon be a reality- ABC News @ABC - https://t.co/Ul6O12RuEU 👇🏾See our interview on how blood tests ➡️ #LiquidBiopsies 🧪🧬 are moving up🪜to #detection. @WeillCornell @WCMEnglanderIPM @nyphospital @WCM_MeyerCancer

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