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Mashup Score: 8Immunomodulatory soluble HLA-G and HLA-E are associated with rapidly deteriorating CLAD and HCMV viremia after lung transplantation - 1 day(s) ago
Plasma-soluble (s)HLA-G and sHLA-E are immunoregulatory proteins that balance the activation of NKG2A+ immune cells. In lung-transplant recipients (LTRs), dysregulated NKG2A+ natural killer cell responses may result in high-level human cytomegalovirus (HCMV) replication as well as chronic lung allograft dysfunction (CLAD), and especially the development of rapidly deteriorating CLAD is associated with high mortality. We thus analyzed the kinetics and function of sHLA-G and sHLA-E in follow-up samples of N = 76 LTRs to evaluate whether these immunoregulatory proteins are associated with the risk for CLAD and high-level HCMV replication.
Source: www.jhltonline.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 0
We discovered a threshold for reduced BALF CCSP to discriminate future CLAD risk; supporting the utility of BALF CCSP as a tool for early posttransplant risk stratification. Additionally, our finding that low CCSP associates with future CLAD underscores a role for club cell injury in CLAD pathobiolo …
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
1⃣ @NCortesMD of @TexasChildrens presents a study by Jamie Todd, et al, from @TheJHLT on if club cell secretory protein (#CSSP) levels in #BALF can serve as a #biomarker for #CLAD. 🫁▶️https://t.co/jl6uGUsE0j #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/LfkHIYcge6
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Mashup Score: 0Diagnostic performance of electronic nose technology in chronic lung allograft dysfunction - 2 year(s) ago
There is a need for reliable biomarkers for the diagnosis of chronic lung allograft dysfunction (CLAD). In this light, we investigated the diagnostic value of exhaled breath analysis using an electronic nose (eNose) for CLAD, CLAD phenotype, and CLAD stage in lung transplant recipients (LTR).
Categories: Cardiology News and Journals, Latest HeadlinesTweet-
Exhaled breath analysis using eNose technology is a promising novel biomarker for #CLAD and could be a valuable addition to the diagnostic armamentarium for suspected graft failure after #lungtransplant. 🔗: https://t.co/LRFwT2BoeV https://t.co/NWHjFgVQez
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Mashup Score: 0
Long term outcomes of lung transplantation are impacted by the occurrence of chronic lung allograft dysfunction (CLAD). Recent evidence suggests a role for the lung microbiome in the occurrence of CLAD, but the exact mechanisms are not well defined. We hypothesize that the lung microbiome inhibits epithelial autophagic clearance of pro-fibrotic proteins in an IL-33 dependent manner, thereby…
Categories: Cardiology News and Journals, Latest HeadlinesTweet-
#Originalscience showing #CLAD is associated with ⏫airway IL-33 expression & reduced basal autophagy. Pseudomonas in #lungtransplant induces fibrogenic response by inhibiting airway epithelial autophagy in an IL-33 dependent manner. @NirmalSSharmaMD 🔗:https://t.co/Eyn9ZDf4rI https://t.co/r8fnpx0qgb
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Mashup Score: 0JHLT: The Podcast - 2 year(s) ago
The Journal of Heart and Lung Transplantation podcast features editor Daniel Goldstein, MD, in round table talks with the JHLT’s digital media editors.
Source: thejhlt.libsyn.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Catch up on #JHLTThePodcast with this month's episode on #COVID19. Studies by @YaelPeledPotash and @TjiGan. ▶️4th vaccines💉 against #Delta and #Omicron ▶️#CLAD and lung function 🫁 in #LungTx patients with COVID 🎧Listen now @ https://t.co/e4S3I4I0P4 or in your podcatcher.
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Mashup Score: 5JHLT: The Podcast - 2 year(s) ago
The Journal of Heart and Lung Transplantation podcast features editor Daniel Goldstein, MD, in round table talks with the JHLT’s digital media editors.
Source: thejhlt.libsyn.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
September's #JHLTThePodcast is all about #COVID19, with studies by @YaelPeledPotash and @TjiGan. ▶️We discuss 4th vaccines💉 against #Delta and #Omicron, and #CLAD and lung function 🫁 in #LungTx patients with COVID. 🎧Listen now @ https://t.co/e4S3I4I0P4 or in your podcatcher. https://t.co/jQfYsYJxKK
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Mashup Score: 0Loss of stromal cell Thy-1 plays a critical role in lipopolysaccharide induced chronic lung allograft dysfunction - 2 year(s) ago
Long-term survival of lung transplants lags behind other solid organs due to early onset of a fibrotic form of chronic rejection known as chronic lung allograft dysfunction (CLAD). Preventing CLAD is difficult as multiple immunologic and physiologic insults contribute to its development. Targeting fibroblast activation, which is the final common pathway leading to CLAD, offers the opportunity to…
Categories: Cardiology News and Journals, Latest HeadlinesTweet-
Loss of the glycoprotein Thy-1 on fibroblasts is a previously unrecognized cause of #CLAD and its replacement may offer therapeutic applications for amelioration of this disease after #lungtransplant in the setting of infectious stress responses. https://t.co/d6QS2IiCLM https://t.co/MFVNpnN7yY
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Mashup Score: 0
Hear from the FIRST-EVER winner of the ISHLT Innovation Challenge Award, sponsored by CareDx. Dr. Sáez-Giménez discusses her project, “Dd-cfDNA to Monitor CL…
Source: YouTubeCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Here's Berta Saez-Gimenez @udvhebronUAB, first winner of the #ISHLT Innovation Challenge Award, sponsored by @CareDx. She discusses using #ddcfDNA to monitor #CLAD treatment and many ways #biomarkers could be used to monitor/treat ongoing lung disease. https://t.co/4fBUGa7kA8
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Mashup Score: 0Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors - 3 year(s) ago
Lung transplantation from uncontrolled and controlled donors after circulatory death offers similar outcomes to brain death donors in terms of early and mid-term results. Overall survival and CLAD-fr…
Source: Wiley Online LibraryCategories: Latest Headlines, TransplantationTweet-
#LungTransplant from uncontrolled and controlled #DCD offers similar outcomes to #DBD in terms of early and mid-term results, with comparable overall survival and #CLAD-free survival at 1 and 3 years between the three types of donors https://t.co/pz9kJqn8BJ https://t.co/80tGmfc0qB
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Mashup Score: 3The Therakos Institute – Our Webinars - 3 year(s) ago
We offer a series of lectures delivered by pioneering experts with relevance to ECP and its clinical applications. Sign up for the next webinar or stream past webinars on-demand.
Source: www.therakos.euCategories: Cardiology News and Journals, Latest HeadlinesTweet-
NEXT WEEK: #ISHLTv supporters @MNK will be hosting a free #webinar on 19 October on the role and impact of #ECP in the treatment of #CLAD patients, featuring Dr. Mark Greer. This webinar is intended for practitioners OUTSIDE the US/Canada. Get registered: https://t.co/JTISnKovdy
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The development of rapidly deteriorating chronic lung allograft dysfunction (#CLAD) in lung-transplant recipients is highly dependent on the plasma titer of the immunomodulatory molecule sHLA-G. 🫁 🔗: https://t.co/lDBm0S7owr