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Mashup Score: 6Recipient Outcomes with Extended Criteria Donors Using Advanced Heart Preservation: An Analysis of the GUARDIAN Heart Registry - 2 day(s) ago
The prevalence of end stage heart failure and patients that could benefit from heart transplantation requires an expansion of the donor pool, relying on the transplant community to continually re-evaluate and expand the use of extended criteria donor organs. Introduction of new technologies such as the Paragonix SherpaPak Cardiac Transport System aids in this shift. We seek to analyze the impact of the SherpaPak system on recipient outcomes who receive extended criteria organs in the GUARDIAN Heart Registry.
Source: www.jhltonline.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy - 3 day(s) ago
Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV.
Source: www.jhltonline.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 7Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection - 4 day(s) ago
Chronic rejection, closely related to the activation of B cells and donor-specific antibody (DSA) production, has unsatisfactory therapeutic outcomes. B lymphocyte stimulator (BLyS) is a major regulatory factor that controls the activation and differentiation of B cells. However, it remains unclear whether BLyS blockade can regulate B and plasma cells in the transplantation setting and affect chronic rejection. Here, we investigated the efficacy of the BLyS inhibitors belimumab and telitacicept in controlling B-cell response and preventing chronic rejection.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 3
Dear Editor,
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 21
The physiological response of the right ventricle (RV) following left ventricular assist device (LVAD) implantation is difficult to predict. We aimed to investigate RV geometric and functional changes after LVAD insertion and their effects on clinical outcomes.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet-
Changes in RV dimensions are not included in risk predictions post LVAD. A non-adapted RV was associated with alterations TV & RV geometry, leading to worsening TR. This may help identify patients that may be refractory to LVAD therapy. @HideyukiHayash6 🔗 https://t.co/m0vkYBMX3T https://t.co/cB6Y6O1xjn
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Mashup Score: 5Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates - 9 day(s) ago
Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Accurate prediction of PGD risk could inform donor approaches and perioperative care planning. We sought to develop a clinically useful, generalizable PGD prediction model to aid in transplant decision-making.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 20A multicenter evaluation of the HeartMate 3 risk score - 9 day(s) ago
The Heartmate 3 (HM3) risk score (HM3RS) was derived and validated internally from within the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3 (MOMENTUM 3) trial population and provides 1- and 2-year mortality risk prediction for patients in those before HM3 left ventricular assist device (LVAD) implantation. We aimed to evaluate the HM3RS in nontrial unselected patients, including those not meeting inclusion criteria for MOMENTUM 3 trial enrollment.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 4
To the Editor,
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 1Impact of recipient age on mortality among Cytomegalovirus (CMV)-seronegative lung transplant recipients with CMV-seropositive donors - 11 day(s) ago
Cytomegalovirus (CMV)-seronegative lung transplant recipients (LTRs) with seropositive donors (CMV D+/R−) have the highest mortality of all CMV serostatuses. Due to immunosenescence and other factors, we hypothesized CMV D+/R− status might disproportionately impact older LTRs. Thus, we investigated whether recipient age modified the relationship between donor CMV status and mortality among CMV-seronegative LTRs.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
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Mashup Score: 2Gastrointestinal bleeding following Heartmate 3 left ventricular assist device implantation: The Michigan Bleeding Risk Model - 13 day(s) ago
Gastrointestinal bleeding (GIB) results in frequent hospitalizations and impairs quality of life in durable left ventricular assist device (LVAD) recipients. Anticipation of these events before implantation could have important implications for patient selection and management.
Source: www.jhltonline.orgCategories: General Medicine News, Cardiology News and JournTweet
RT @MerThomp: 🗣️ New @TheJHLT publication on using #SherpaPak to expand access to more donors! https://t.co/v6WpwqMCkB Congrats to inv…