• Mashup Score: 0
    Scientists Finish the Human Genome at Last - 3 year(s) ago

    The complete genome uncovered more than 100 new genes that are probably functional, and many new variants that may be linked to diseases.

    Source: www.nytimes.com
    Categories: Future of Medicine, Latest Headlines
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    • Profile photo of PulmonaryApps
      PulmonaryApps

      The complete genome uncovered more than 100 new genes that are probably functional, and many new variants that may be linked to diseases via @nytimes https://t.co/QTSfa3TwjA #DNA #chromosomes #genome #krystalklear #pulmonaryapps https://t.co/4IbNNDDhts

  • Mashup Score: 6
    Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome - 3 year(s) ago

    Author summary Y chromosomes can be toxic. The Y chromosome of many species contains a large number of transposable elements (TEs), which are transcriptionally constrained by repressive chromatin marks. When relieved of these epigenetic modifications, many TEs can readily move from one genomic location to another. We show that TEs located on the Y chromosome are less effectively silenced in male…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      ♂️ Toxic Y #chromosomes? Nguyen & Bachtrog investigate how repeats on the Y chromosome may affect sex-specific differences in #lifespan They find that #Drosophila Y chromosomes with more repeats less effectively silence transposable elements 📰 https://t.co/Ik1QVXDebY 📷 Fig1B https://t.co/G4wIbHo662

  • Mashup Score: 0
    Evolutionary dynamics of the human pseudoautosomal regions - 3 year(s) ago

    Author summary The pseudoautosomal regions (PAR1 and PAR2) of the human sex chromosomes contain the unique blocks of homologous sequences between the X and Y chromosomes that allow pairing and recombination during male meiosis. Both PARs present a distinctive transmission behavior that includes the properties of either sex-linked or autosomal regions (hence the pseudoautosomal status). However,…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      The pseudoautosomal regions of human X and Y #chromosomes allow pairing during #meiosis Monteiro et al. found an uneven distribution of recombination throughout the regions Low recombination segments were also associated with more linkage disequilibrium https://t.co/wOIwmYt2j5

  • Mashup Score: 8
    3D genomics across the tree of life reveals condensin II as a determinant of architecture type - 3 year(s) ago

    The conformation of chromosomes within the nucleus can reflect a cell’s type or state. However, studies of the conservation and evolutionary history of the mechanisms regulating genome structure across species are lacking. Hoencamp et al. mapped three-dimensional (3D) genome organization in 24 eukaryote species, including animals, fungi, and plants. At interphase, species’ telomeres and…

    Source: Science
    Categories: Healthcare Professionals, Latest Headlines
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    • Profile photo of westr
      westr

      3D #genomics across the tree of life reveals #condensin II as a determinant of architecture type https://t.co/Y6jYFnS9J9 #genomes #chromosomes #heterochromatin

  • Mashup Score: 0
    Behavior of dicentric chromosomes in budding yeast - 3 year(s) ago

    Author summary A challenge in chromosome biology is to integrate the linear code with spatial organization and chromosome dynamics within the nucleus. The major sub-division of function in the nucleus is the nucleolus, the site of ribosomal RNA synthesis. We report that the pericentromere DNA surrounding the centromere is another region of confined biochemistry. We have found that chromosome…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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    • Profile photo of PLOSGenetics
      PLOSGenetics

      #DNA double-stranded break repair pathways in #yeast dicentric #chromosomes: Cook et al. find that breaks between 2 centromeres <20 kb apart w/in the pericentromere favor end-joining, while breaks between centromeres >20 kb apart favor HR or SSA. https://t.co/vNjfl78NhM

  • Mashup Score: 10
    New finding reveals how some cancers gain or lose chromosomes - 3 year(s) ago

    In human cells, CCR researchers have discovered how overexpression of just one protein can lead to the formation of a cell with an abnormal number of chromosomes – a hallmark feature of some aggressive cancers that are associated with a poor prognosis. The findings published Feb. 23, 2021, in the Journal of Cell Biology.

    Source: Center for Cancer Research
    Categories: Hem/Onc News and Journals, Latest Headlines
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      theNCI

      New finding reveals how some cancers gain or lose chromosomes: https://t.co/aSLELU1vh7 @NCIResearchCtr #DNA #chromosomes https://t.co/yQWfjOYH9Z

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