• Mashup Score: 2
    Newts unleashed: Limb muscle regeneration needs metamorphosis and body growth - 2 year(s) ago

    Researchers from the University of Tsukuba have found that muscle fibers in Japanese Fire-bellied Newts have an intrinsic ability to dedifferentiate, or reprogram, and contribute to limb regeneration. The results indicate that changes in the niche (the environment outside the cell) during metamorphosis and body growth are needed to unleash this ability. This study provides a key basis for future…

    Source: EurekAlert!
    Categories: General Medicine News, Latest Headlines
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      EurekAlert

      The hidden powers of #newts: Muscle cells reprogram during limb #regeneration thanks to metamorphosis and body growth @UNIV_TSUKUBA_EN #lifesciences #amphibians #cellbiology https://t.co/O9gAfYQkvk

  • Mashup Score: 0
    Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate - 2 year(s) ago

    Author summary It is not yet clear how highly related factors like the ARP/Ascl factors display specific activities even though they recognize the same consensus DNA motif. This specificity could be provided by their cellular environment or by intrinsic properties of the factors themselves. To distinguish between these two possibilities, we have expressed several ARP/Ascl factors in the ascl1a-/-…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      New research on cell fate specification: Reuter et al study ARP/ASCL transcription factors in #zebrafish embryos They show the Neurod1 protein can repress Gfi1 to influence the balance between cell fates #genetics #CellBiology https://t.co/XNI2zqKMZ0

  • Mashup Score: 1
    Tunneling Nanotubes between Cells Migrating in ECM Mimicking Fibrous Environments - 2 year(s) ago

    Tunneling nanotubes (TNTs) comprise a unique class of actin-rich nanoscale membranous protrusions. They enable long-distance intercellular communication and may play an integral role in tumor formation, progression, and drug resistance. TNTs are three-dimensional, but nearly all studies have investigated them using two-dimensional cell culture models. Here, we applied a unique 3D culture platform…

    Source: MDPI
    Categories: Hem/Oncs, Latest Headlines
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      cancerassassin1

      This is the link to the recently published #openaccess paper from our team that the image is from: Tunneling Nanotubes between Cells Migrating in ECM Mimicking Fibrous Environments https://t.co/7TTMSiE79d #tunnelingnanotubes #cellbiology @MRC_LMS @UMNCancer https://t.co/7tgM7mwo0P

  • Mashup Score: 0
    ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways - 2 year(s) ago

    Author summary Membrane contact sites (MCSs) between the two largest cellular membranes, the endoplasmic reticulum (ER) and the plasma membrane (PM), are regulatory interfaces for lipid synthesis and bidirectional transport. The yeast Osh protein family, which represents the seven yeast oxysterol-binding protein related proteins (ORPs), is implicated in MCS regulation and lipid transfer between…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      New #research on the endoplasmic reticulum (ER): Quon et al find that #yeast ER-plasma membrane (PM) tether genes affect phospholipid regulation They find these genes protect the PM and ER through membrane stress responses #Genetics #CellBiology https://t.co/muBwrTxibl

  • Mashup Score: 2
    Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate - 2 year(s) ago

    Author summary It is not yet clear how highly related factors like the ARP/Ascl factors display specific activities even though they recognize the same consensus DNA motif. This specificity could be provided by their cellular environment or by intrinsic properties of the factors themselves. To distinguish between these two possibilities, we have expressed several ARP/Ascl factors in the ascl1a-/-…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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    • Profile photo of PLOSGenetics
      PLOSGenetics

      New research on cell fate specification: Reuter et al @GIGA_ULiege study ARP/ASCL transcription factors in #zebrafish embryos They show the Neurod1 protein can repress Gfi1 to influence the balance between cell fates #genetics #CellBiology https://t.co/XNI2zqKMZ0

  • Mashup Score: 8
    Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteria - 2 year(s) ago

    Author summary Much like armor, the OM of Gram-negative bacteria serves as the cell’s first line of defense against harsh environments and toxic molecules. The two major components of the OM are LPS and GPLs. To offer effective protection, the cell must maintain the appropriate balance of LPS and GPLs at the bacterial surface. Here we report that members of the “AsmA-like” family, YhdP, TamB, and…

    Source: journals.plos.org
    Categories: Genetics, Latest Headlines
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      PLOSGenetics

      How do phospholipids move from the inner to outer membrane of Gram-negative #bacteria? Douglass et al @m_strent show that members of the “AsmA-like” family aid in transport & are critical for #antibiotics resistance 🔎: https://t.co/o1VgylXx0h #genetics #CellBiology https://t.co/ZVUbhmLv35

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