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Mashup Score: 0Infiltrating T-cell markers in cervical carcinogenesis: a systematic review and meta-analysis - 3 year(s) ago
The host adaptive immune response helps determine which cervical HPV infections persist and progress to precancer and cancer, and systematic characterisation of T-cell infiltration would help inform key steps in cervical carcinogenesis. A systematic review and meta-analysis were conducted of infiltrating T-cells in normal cervix, low-grade lesions, high-grade lesions, and invasive cancers…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0DNA Methylation–Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk - 4 year(s) ago
Background: Pancreatic cancer is projected to become the second most common cause of cancer-related death over the next 5 years. Because inflammation is thought to be a common trajectory for disease initiation, we sought to prospectively characterize immune profiles using DNA methylation markers and examine DNA methylation levels previously linked to inflammation biomarkers to evaluate whether…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Michaud et al identify several CpGs residing in or near gene MNDA sites that may play a role in pancreatic #carcinogenesis and find that their methylation was significantly associated with #PancreaticCancer risk. @TuftsMedSchool https://t.co/BEq81KtVoF https://t.co/69Sj2m1eZM
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Mashup Score: 0Relationships between breast feeding and breast cancer subtypes: lessons learned from studies in humans and in mice - 4 year(s) ago
There are differential risk relationships between parity and breast cancer according to estrogen receptor (ER) status, with an increased risk of ER- disease reduced by breastfeeding. This may be particularly relevant for understanding the higher incidence of ER- tumors in Black women, who are more likely to be parous and less likely to breastfeed than other US groups. Potential mechanisms for…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Ambrosone and Higgins review how parity, #BreastFeeding and #BreastCancer subtypes may influence breast #carcinogenesis, with a focus on effects on progenitor cell pools in the mammary gland. ReviewArticle @cambros1 https://t.co/eQsQZR4L5a https://t.co/AONfHxhfRa
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Mashup Score: 0DNA Methylation–Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk - 4 year(s) ago
Background: Pancreatic cancer is projected to become the second most common cause of cancer-related death over the next 5 years. Because inflammation is thought to be a common trajectory for disease initiation, we sought to prospectively characterize immune profiles using DNA methylation markers and examine DNA methylation levels previously linked to inflammation biomarkers to evaluate whether…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Michaud et al identify several CpGs residing in or near gene MNDA sites that may play a role in pancreatic #carcinogenesis and find that their methylation was significantly associated with #PancreaticCancer risk. @TuftsMedSchool https://t.co/4FelfnsvlY https://t.co/yEZy4ZSnL3
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Mashup Score: 2DNA Methylation–Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk - 4 year(s) ago
Background: Pancreatic cancer is projected to become the second most common cause of cancer-related death over the next 5 years. Because inflammation is thought to be a common trajectory for disease initiation, we sought to prospectively characterize immune profiles using DNA methylation markers and examine DNA methylation levels previously linked to inflammation biomarkers to evaluate whether…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Michaud et al identify several CpGs residing in or near gene MNDA sites that may play a role in pancreatic #carcinogenesis and find that CpG methylation was significantly associated with #PancreaticCancer risk. @TuftsMedSchool https://t.co/SAktLGGtEe https://t.co/w6tbatK7c4
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Mashup Score: 0
BRCA1 gene mutations impair homologous recombination (HR) DNA repair, resulting in cellular senescence and embryonic lethality in mice. Therefore, BRCA1-deficient cancers require adaptations that prevent excessive genomic alterations from triggering cell death. RNF168-mediated ubiquitination of ÎłH2AX at K13/15 (ub-H2AX) serves as a recruitment module for the localization of 53BP1 to DNA break…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Krais et al identify loss of RNF168 ubiquitin signaling as a #proteomic alteration that supports #BRCA1 mutant #carcinogenesis and propose a new therapeutic approach based on that finding. @FoxChaseCancer https://t.co/1BCh8kcfbl https://t.co/xbBqCzh4rZ
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Mashup Score: 0
The incidence of esophageal adenocarcinoma is rising, survival remains poor, and new tools to improve early diagnosis and precise treatment are needed. Cancer phospholipidomes quantified with mass spectrometry imaging (MSI) can support objective diagnosis in minutes using a routine frozen tissue section. However, whether MSI can objectively identify primary esophageal adenocarcinoma is currently…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Abbassi-Ghadi et al show that DESI-MSI can identify invasive esophageal #adenocarcinoma. Further studies are needed to determine how polyunsaturated phosphatidylglycerols contribute to #Carcinogenesis. @imperialcollege https://t.co/znxvTrmbDb https://t.co/JsBPS6nWP8
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Mashup Score: 0
Overall, we demonstrate that specific lipid metabolic pathways are coherently altered when hepatocytes switch to proliferation. These represent a source of targets for the development of new therapeutic strategies and prognostic biomarkers of HCC.
Source: PubMedCategories: Gastroenterology, Latest HeadlinesTweet-
Monounsaturated phosphatidylchilines are correlated with hallmarks of cell #proliferation and #carcinogenesis in #HCC https://t.co/BEuUyA8aXy @zoehall_ICL https://t.co/c5RUy7eH8t
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Mashup Score: 1Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis - 4 year(s) ago
Pak1 (serine/threonine p21-activated kinases) was previously reported to have oncogenic activity in several cancers. However, its roles in the cancer microenvironment are poorly understood. We demonstrated that Pak1 expression in Langerhans cells (LCs) is essential for the maintenance of epidermal stem cells and skin tumor development. We found that PAK1 is localized in LCs by…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
A novel #discovery about Pak1 in epidermal #stem cell regulation and skin #carcinogenesis now available to read in @oncogenejournal https://t.co/AkYUb7m1xc
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Mashup Score: 0
The incidence of esophageal adenocarcinoma is rising, survival remains poor, and new tools to improve early diagnosis and precise treatment are needed. Cancer phospholipidomes quantified with mass spectrometry imaging can support objective diagnosis in minutes using a routine frozen tissue section. However, whether mass spectrometry imaging can objectively identify primary esophageal…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Abbassi-Ghadi et al show that DESI-MSI can identify invasive esophageal #adenocarcinoma. Further studies are needed to determine how polyunsaturated phosphatidylglycerols contribute to #Carcinogenesis. @imperialcollege https://t.co/d6EChSBLnt https://t.co/XfBTXVhWAQ
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đź“Ł @tamaralitwin et al. have conducted a systematic review and meta-analysis regarding infiltrating T-cell markers in cervical #carcinogenesis in a new study in the BJC's #Epidemiology section. https://t.co/w9A5Q2LDqA https://t.co/NK2IHp7f74