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Mashup Score: 3Thymidylate synthase O-GlcNAcylation: a molecular mechanism of 5-FU sensitization in colorectal cancer - Oncogene - 2 year(s) ago
Alteration of O-GlcNAcylation, a dynamic posttranslational modification, is associated with tumorigenesis and tumor progression. Its role in chemotherapy response is poorly investigated. Standard treatment for colorectal cancer (CRC), 5-fluorouracil (5-FU), mainly targets Thymidylate Synthase (TS). TS O-GlcNAcylation was reported but not investigated yet. We hypothesize that O-GlcNAcylation…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Tight junction protein 1 promotes vasculature remodeling via regulating USP2/TWIST1 in bladder cancer - Oncogene - 2 year(s) ago
Bladder cancer (BLCA) is the most common malignant tumor of the urinary system and is characterized by high metastatic rates and poor prognosis. The expression of tight junction protein 1 (TJP1) is associated with bladder cancer invasion; however, the mechanism by which TJP1 affects vasculature remodeling remains unknown. In this study, we found that TJP1 expression correlated with tumor…
Source: OncogeneCategories: Latest Headlines, UrologyTweet-
TJP1 promotes angiogenesis in bladder cancer cells via TWIST-dependent regulation of CCL2, says a new article in @oncogenejournal https://t.co/BoPd7pZgti
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Mashup Score: 1IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma - Oncogene - 2 year(s) ago
As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy. Preventing p53/Mdm2 interaction by Nutlin-3, the prototypical Mdm2 antagonist, or via direct siRNA Mdm2 depletion, increased p53 and inhibited viability in CM cell lines. The sensitivity to Nutlin-3 p53 reactivation with concomitant Mdm2 stabilization…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Two targets for the price of one! Research led by @LGirnita at @karolinskainst identifies dual oncogene and tumour suppressor control via #Nutlin-3 that may finally bring precision oncology to #ConjunctivalMelanoma patients. 👉https://t.co/J3ahsS99Km #Melanoma #TargetedTherapy
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Mashup Score: 0
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. Aiming to exploit this effect in therapy we performed a compound screen in five breast cancer cell lines…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
👨🔬👩🔬 Exploiting the vulnerabilities of IGF-inhibited cells: @DrGuillaume_PhD & co-workers show that co-targeting IGF with CHK1 or WEE1 may have potential as a novel therapeutic strategy. 👉 https://t.co/R2qwXex8JV
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Mashup Score: 0Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress - Oncogene - 2 year(s) ago
Reactive oxygen species (ROS) serve as critical signals in various cellular processes. Excessive ROS cause cell death or senescence and mediates the therapeutic effect of many cancer drugs. Recent studies showed that ROS increasingly accumulate during G2/M arrest, the underlying mechanism, however, has not been fully elucidated. Here, we show that in cancer cells treated with anticancer agent…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Antineoplastic oxidative stress: The story of M phase arrest & impairment of mitochondrial homeostasis. #OpenAccess in our latest issue: 👉 https://t.co/Rcaf8y3zl4
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Mashup Score: 3
Although tobacco smoking is a risk factor for lung adenocarcinoma (LUAD), the mechanisms by which tobacco smoking induces LUAD development remain elusive. Histone methylation levels in human bronchial epithelial cells have been reported to increase after exposure to cigarettes. In this study, we explored the mechanisms regulating histone methylation in LUAD in response to smoking. We found that…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
❓ How does smoking induce #LungCancer? 🧬 This #OpenAccess report brings us one step closer to understanding the mechanism: https://t.co/ellf0lIAKJ
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Mashup Score: 8Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies - Oncogene - 3 year(s) ago
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) of just 9–11-months, DMG is characterized by global hypomethylation of histone H3 at lysine 27 (H3K27me3), driven by recurring somatic mutations in H3 genes including, HIST1H3B/C…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
🔎 On genomic, non-genomic & exogenous factors that contribute to #DMG #DIPG initiation & progression. A systems-wide view to highlight factors that underpin poor outcomes and strategies to improve treatment. #OpenAccess from @MattDun17, @sebastianw & co: https://t.co/DPBwv7i682
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Mashup Score: 11Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies - Oncogene - 3 year(s) ago
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) of just 9–11-months, DMG is characterized by global hypomethylation of histone H3 at lysine 27 (H3K27me3), driven by recurring somatic mutations in H3 genes including, HIST1H3B/C…
Source: OncogeneCategories: Latest Headlines, Oncologists1Tweet-
Congrats to Izac, #DunLab, @sebastianw, @MattDun17, and the team on a truly in depth analysis in @oncogenejournal that will build toward real time testing of the proteomics of #DIPG/#DMG - critical to #CART. @seattlechildren #VitanzaLab #EndDIPG #EndDIPG https://t.co/6PRKdYq7NN https://t.co/wsHGsQuErH
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Mashup Score: 1Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis - Oncogene - 3 year(s) ago
In addition to its classical role in apoptosis, accumulating evidence suggests that caspase-2 has non-apoptotic functions, including regulation of cell division. Loss of caspase-2 is known to increase proliferation rates but how caspase-2 is regulating this process is currently unclear. We show that caspase-2 is activated in dividing cells in G1-phase of the cell cycle. In the absence of…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
🧬Watching caspase-2 get active in cell division! A new paper from @LisaBHayes_lab sheds more light on non-apoptotic functions of caspase-2: 👉https://t.co/BK8Wm6ZBRy
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Mashup Score: 0
Gastric cancer (GC) has the fifth highest incidence globally, but its molecular mechanisms are not well understood. Here, we report that coactivator-associated arginine methyltransferase 1 (CARM1) is specifically highly expressed in gastric cancer and that its overexpression correlates with poor prognosis in patients with gastric cancer. Nucleoporin 54 (Nup54) was identified as a…
Source: OncogeneCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
One step further towards understanding the mechanism of #GastricCancer: CARM1 mediates transcriptional activation of the Notch2 signalling pathway leading to cancer progression. 🔎 https://t.co/6FRDEzbATm
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Could combining 5-FU-based chemotherapy with Thiamet-G be a new way to enhance #ColorectalCancer response to 5-FU? 👉 https://t.co/vbWaXEsM9c #CancerResearch @univ_lille