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Mashup Score: 0Wolters Kluwer Health - 1 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…
Source: lww.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Using a panel of cancer cell lines, we characterized a novel degrader of AKT, MS21. In mutant PI3K–PTEN pathway cell lines, AKT degradation was superior to AKT kinase inhibition for reducing cell growth and sustaining lower signaling over many days. AKT degradation, but not kinase inhibition, profoundly lowered Aurora kinase B (AURKB) protein, which is known to be essential for cell division, and…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2 - PubMed - 3 year(s) ago
Together, the data presented here demonstrate SC79 activation of Akt induces potentially anti-pathogenic NO production, antioxidant gene transcription, reduces IL-8 transcription, and may protect against oxidative barrier dysfunction in a wide range of airway epithelial cells.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0
Rationale: The β2-adrenoceptor (β2-AR), a prototypical GPCR (G protein-coupled receptor), couples to both Gs and Gi proteins. Stimulation of the β2-AR is beneficial to humans and animals with heart f
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
Use of Ipatasertib in Patients Who Present With #AKT Mutation Tumors: https://t.co/rKAW7vaXvv https://t.co/LBNfYGpoTk