• Mashup Score: 1
    Outcome for Children and Young Adults With T-Cell ALL and Induction Failure in Contemporary Trials - 8 month(s) ago

    PURPOSE Historically, patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission at the end of induction (EOI) have had poor long-term survival. The goal of this study was to examine the efficacy of contemporary therapy, including allogeneic hematopoietic stem cell transplantation (HSCT) in first remission (CR1). METHODS Induction failure (IF) was defined as the persistence of at least 5% bone marrow (BM) lymphoblasts and/or extramedullary disease after 4-6 weeks of induction chemotherapy. Disease features and clinical outcomes were reported in 325 of 6,167 (5%) patients age 21 years and younger treated in 14 cooperative study groups between 2000 and 2018. RESULTS With a median follow-up period of 6.4 years (range, 0.3-17.9 years), the 10-year overall survival (OS) was 54.7% (SE = 2.9), which is significantly higher than the 27.6% (SE = 2.9) observed in the historical cohort from 1985 to 2000. There was no significant impact of sex, age, white blood cell co

    Source: ascopubs.org
    Categories: Hem/Onc News and Journals, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of ASCO_pubs
      ASCO_pubs

      🙌 Outcome improvement for T-cell #AcuteLymphoblasticLeukemia and induction failure in a contemporary treatment era ➡️ https://t.co/z30ElUTj4M #leusm #AYACSM https://t.co/pwVy1itPPD

  • Mashup Score: 0
    Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012–2016 - 9 month(s) ago

    AbstractBackground:. Acute lymphoblastic leukemia (ALL) accounts for 80% of all leukemias diagnosed in children. Although ALL age patterns are consistent across racial/ethnic groups, their incidence and mortality rates are highly variable. We assessed the age-standardized ALL incidence and mortality rates of Puerto Rican Hispanic (PRH) children and compared them with those of US mainland Hispanics (USH), non-Hispanic Whites (NHW), non-Hispanic Blacks (NHB), and Non-Hispanic Asian or Pacific Islanders (NHAPI).Methods:. Differences between racial/ethnic groups were assessed by estimating the standardized rate ratio (SRR) for 2010 to 2014. Secondary data analyses of the Puerto Rico Central Cancer Registry and the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) databases were performed for the 2001 to 2016 period.Results:. PRH children had 31% lower incidence rates than USH, but 86% higher incidence rates than NHB. In addition, the incidence trends of ALL inc

    Source: aacrjournals.org
    Categories: Hem/Onc News and Journals, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of CEBP_AACR
      CEBP_AACR

      #ICYMI: Incidence and mortality rates for #AcuteLymphoblasticLeukemia are highly variable. Montes-Rodríguez et al present the first study comparing childhood ALL between Puerto Rican Hispanic children and children of other racial/ethnic groups in the US. https://t.co/UJIfmT0rex https://t.co/kMYu9RBcL7

  • Mashup Score: 0
    Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012–2016 - 9 month(s) ago

    AbstractBackground:. Acute lymphoblastic leukemia (ALL) accounts for 80% of all leukemias diagnosed in children. Although ALL age patterns are consistent across racial/ethnic groups, their incidence and mortality rates are highly variable. We assessed the age-standardized ALL incidence and mortality rates of Puerto Rican Hispanic (PRH) children and compared them with those of US mainland Hispanics (USH), non-Hispanic Whites (NHW), non-Hispanic Blacks (NHB), and Non-Hispanic Asian or Pacific Islanders (NHAPI).Methods:. Differences between racial/ethnic groups were assessed by estimating the standardized rate ratio (SRR) for 2010 to 2014. Secondary data analyses of the Puerto Rico Central Cancer Registry and the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) databases were performed for the 2001 to 2016 period.Results:. PRH children had 31% lower incidence rates than USH, but 86% higher incidence rates than NHB. In addition, the incidence trends of ALL inc

    Source: aacrjournals.org
    Categories: Hem/Onc News and Journals, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of CEBP_AACR
      CEBP_AACR

      Incidence and mortality rates for #AcuteLymphoblasticLeukemia are highly variable. Montes-Rodríguez et al present the first study comparing childhood ALL between Puerto Rican Hispanic children and children of other racial/ethnic groups in the US. https://t.co/HR47mfMeUj https://t.co/l8FDntXwTQ

  • Mashup Score: 0
    Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia - Nature Communications - 1 year(s) ago

    High hyperdiploid acute lymphoblastic leukaemia (HeH ALL) is driven by nonrandom chromosomal gains, which have been suggested to arise early – even before birth. Here, the authors use single-cell whole genome sequencing and in silico modelling to show that HeH ALL aneuploidies could originate early and follow punctuated evolution.

    Source: Nature
    Categories: General Medicine News, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of NatureComms
      NatureComms

      Analysis of high hyperdiploid #AcuteLymphoblasticLeukemia with #SingleCell #WholeGenomeSequencing and #InSilico modelling supports that chromosome gains could have early origin and follow punctuated #evolution #CancerResearch @natrescancer https://t.co/yzizcnjKy8 https://t.co/B2Ql5Hxs9g

  • Mashup Score: 3
    ASH 2022 - 1 year(s) ago

    Fred Hutch scientists will present the latest findings on transplantation, cell therapies, precision medicine and more at the 64th Annual American Society of Hematology meeting. The ASH meeting features scientific abstracts highlighting updates on the most critical topics in hematology.

    Source: Fred Hutch
    Categories: Hem/Onc News and Journals, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of fredhutch
      fredhutch

      The fun continues tonight at #ASH22! Hear Drs. Leona Holmberg, Noam Kopmar and @LorenzoIovino1 during their poster presentations. Learn more: https://t.co/COzofgQsA5 📆 Monday, December 12 | 6 pm CT #BMT #MultipleMyeloma #AcuteLymphoblasticLeukemia https://t.co/qbgL5XT37T

Load More