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Mashup Score: 23JCI - BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions - 5 month(s) ago
Abstract We have previously demonstrated that cystatin E/M (CST6), elevated in a subset of multiple myeloma (MM) patients lacking osteolytic lesions (OL), suppresses MM bone disease by blocking osteoclast differentiation and function. CST6 is a secreted type 2 cystatin, a cysteine protease inhibitor that regulates lysosomal cysteine proteases and the asparaginyl endopeptidase legumain. We have…
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Mashup Score: 28JCI - BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions - 5 month(s) ago
ResearchIn-Press PreviewHematologyOncology Open Access | 10.1172/JCI171396 Yan Cheng,1 Jin-Ran Chen,2 Visanu Wanchai,1 David E. Mery,1 Hongwei Xu,1 Dongzheng Gai,1 Samer Al Hadidi,1 Carolina Schinke,1 Sharmilan Thanendrarajan,1 Maurizio Zangari,1 Frits van Rhee,1 Guido Tricot,1 John D….
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Mashup Score: 2JCI - Itaconate suppresses atherosclerosis by activating a Nrf2-dependent anti-inflammatory response in macrophages in mice - 5 month(s) ago
ResearchIn-Press PreviewCardiologyInflammation Open Access | 10.1172/JCI173034 Yanling Zhang,2 Ryan A. Frieler,3 Anthony Andren,3 Sherri C. Wood,1 Daniel J. Tyrrell,5 Peter Sajjakulnukit,3 Jane C. Deng,6 Costas A. Lyssiotis,3 Richard M. Mortensen,3 Morgan Salmon,7 and Daniel R. Goldstein1 1Department…
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Mashup Score: 6JCI - Biomarkers in acute kidney injury: On the cusp of a new era? - 6 month(s) ago
The Moledina, et al. study findings are exciting because they provide a road map of where diagnostics can get to for this common, yet poorly identified and treated, cause of kidney damage (8). The need for a different approach can be readily identified from the fact that clinicians’ gestalt for diagnosing AIN was almost tantamount to tossing a coin (AUC of 0.57) (8). CXCL9 alone out performed not…
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Mashup Score: 6JCI - Intratumoral androgen biosynthesis associated with 3β-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer - 6 month(s) ago
Research ArticleEndocrinologyTherapeutics Open Access | 10.1172/JCI165718 Zaeem Lone,1 Andrew Muskara,1 Jarrell Imamura,1 Aimalie Hardaway,2 Mona Patel,3 Mike Berk,3 Timothy D. Smile,4 Elai Davicioni,5 Kevin L. Stephans,4 Jay Ciezki,4 Christopher J. Weight,5 Shilpa Gupta,4 Chandana A. Reddy,5…
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Mashup Score: 6JCI - Biosynthesis of glucocorticoids in tumors - 6 month(s) ago
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. Find articles by Cirillo, N. in: JCI | PubMed | Google Scholar Published in Volume 133, Issue 21 on November 1, 2023 J Clin Invest. 2023;133(21):e174686. https://doi.org/10.1172/JCI174686. © 2023 Cirillo This work is licensed…
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Mashup Score: 15JCI - Cardiac noradrenergic deficiency revealed by 18F-dopamine positron emission tomography identifies preclinical central Lewy body diseases - 6 month(s) ago
Clinical MedicineIn-Press PreviewNeuroscience Open Access | 10.1172/JCI172460 Courtney Holmes,1 Patti Sullivan,1 Grisel Lopez,2 Janna Gelsomino,1 Sarah Moore,1 Risa Isonaka,1 Tianxia Wu,3 and Yehonatan Sharabi4 1Autonomic Medicine Section, Clinical Neurosciences Program, Division of Int, National Institute of…
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Mashup Score: 41JCI - PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models - 6 month(s) ago
ResearchIn-Press PreviewCell biologyImmunology Open Access | 10.1172/JCI162129 Christian Doreth,1 Yang Li,2 Xiaohui Zhao,1 Emily F. Warner,1 Hannah Chenoweth,1 Kamal Kishore,3 Yagnesh Umrania,4 David-Paul Minde,4 Sarah Winkler,1 Xian Yu,1 Yuning Lu,1 Alice Knapton,1 James Harrison,1…
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Mashup Score: 41JCI - PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models - 6 month(s) ago
ResearchIn-Press PreviewCell biologyImmunology Open Access | 10.1172/JCI162129 Christian Doreth,1 Yang Li,2 Xiaohui Zhao,1 Emily F. Warner,1 Hannah Chenoweth,1 Kamal Kishore,3 Yagnesh Umrania,4 David-Paul Minde,4 Sarah Winkler,1 Xian Yu,1 Yuning Lu,1 Alice Knapton,1 James Harrison,1…
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Mashup Score: 0JCI - Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer - 6 month(s) ago
ResearchIn-Press PreviewOncology Open Access | 10.1172/JCI172503 Elena B. Kabotyanski,1 Alexander B. Saltzman,2 Anna Malovannaya,2 Xueying Yuan,1 Lucas C. Reineke,3 Nadia Lieu,1 Yang Gao,1 Diego A. Pedroza,1 Sebastian J. Calderon,1 Alex J. Smith,1 Clark W. Hamor,1 Kazem Safari,4 Sara R….
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Thank you @RahulBanerjeeMD for highlighting our work led by Fumou @UAMSMyeloma #mmsm @jclinicalinvest 👇 https://t.co/VJxHsHbOed Fumou is a super star&will have another important publication @NatureComms in coming few days exploring new CAR-T construct👇 Photo credit for him https://t.co/83juo3PW39 https://t.co/eXZhUAwBfd