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Mashup Score: 13Shared genetic and epigenetic changes link aging and cancer - 1 year(s) ago
Aging is a universal biological process that increases the risk of multiple diseases including cancer. Growing evidence shows that alterations in the genome and epigenome, driven by similar mechanisms, are found in both aged cells and cancer cells. In this review, we detail the genetic and epigenetic changes associated with normal aging and the mechanisms responsible for these changes. By…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3
Obesity, a global public health concern, is an important risk factor for metabolic diseases and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with the pathologies of obesity; excessive or uncontrolled extracellular matrix (ECM) production in AT has a crucial role in this pathogenesis. The ECM is a critical and functional component of various tissues, providing…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Read this opinion piece from @iUNIST researchers "Extracellular matrix remodeling facilitates obesity-associated cancer progression" published in @TrendsCellBio #AACR23 https://t.co/n48au28k72
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Mashup Score: 60A new time dimension in the fight against metastasis - 1 year(s) ago
The daily light/dark cycle has an immense impact on the physiology and behavior of nearly all living species. To adapt to and optimally respond to environmental changes in a timely manner, most organisms have developed an internal timekeeping system that allows self-sustained, oscillating physiological processes that cycle with a ~24 h period – the circadian rhythm. The term ‘circadian’…
Source: Trends in Cell BiologyCategories: Expert Picks, Latest HeadlinesTweet-
The key and under-appreciated dimension of time and our circadian clock in the diagnosis and treatment of cancer https://t.co/k0v8gEcYrk @TrendsCellBio @CellCellPress @ETH_en https://t.co/6NoSlHOsvP
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Mashup Score: 10Agent-based methods facilitate integrative science in cancer - 1 year(s) ago
In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell and cell–environment interactions that drive cancer progression, therapeutic resistance, and metastasis. These biological phenomena are particularly suited to be captured at the cell-scale resolution possible only within agent-based or individual-based mathematical models. These modeling approaches…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Super chuffed to see @mathoncbro artwork generated with @HybridAutomata on the cover of @TrendsCellBio for our recent article with @markrt_ on how, Agent-based methods facilitate integrative science in cancer. https://t.co/DgxWGEyU07 https://t.co/3EW4RPYTyw
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Mashup Score: 0Extracellular vesicles and nanoparticles: emerging complexities - 1 year(s) ago
Cells communicate with each other by secreting signaling molecules, including proteins, lipids, and nucleic acids. Cells can package these signaling molecules in EVs (see Glossary) in an effort to avoid rapid degradation and escape immune surveillance, among other purposes, resulting in local and long-distance intercellular communication. EVs are lipid-bilayer membrane-enclosed vesicles that are…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Good primer in @TrendsCellBio on the increasingly complex and heterogeneous world of extracellular vesicles: don't just call them #exosomes any more! https://t.co/Jt3rwMkUzR #extracellularvesicles #EV #EVs #cellbio https://t.co/YhpYz3Hjqg
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Mashup Score: 0
Lysosomes are essential catabolic organelles in animal cells. Originally known as the terminal compartments for endocytic and autophagic degradation, lysosomes are now also appreciated for their roles in nutrient sensing, growth signaling, and cellular stress handling, as well as innate and adaptive immunity [1]. These diverse functions are all dependent on the acidic luminal pH and dozens of…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Lysosomal quality control: molecular mechanisms and therapeutic implications https://t.co/eqtpj8iaTH
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Mashup Score: 1Changing the culture for the future: time to take brain drain in academics seriously - 1 year(s) ago
Many trainees (see Glossary) pursue academic careers because of the freedom of independent/critical thinking, intellectual satisfaction of creativity and imagination, and the responsibility of mentoring the next generation of scholars. While all of these qualities are still inspiring, and a society always needs minds of critical and creative thinking, we are approaching a crisis point in…
Source: Trends in Cell BiologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Changing the culture for the future: time to take brain drain in academics seriously - @AshaniTW and colleagues in @trendscancer. Also to note: the brain drain is not specific to the U.S.: many other countries suffer as well. https://t.co/KK63sIyAU4
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Mashup Score: 0Mitotic disassembly and reassembly of nuclear pore complexes - 1 year(s) ago
Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope (NE) that serve as selective gates for macromolecular transport between nucleus and cytoplasm. When higher eukaryotic cells prepare for division, they rapidly disintegrate NPCs during NE breakdown such that nuclear and cytoplasmic components mix to enable the formation of a cytoplasmic mitotic spindle. At the…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Mitotic disassembly and reassembly of nuclear pore complexes - read the full article in @TrendsCellBio Wolfram Antonin, Ramona Jühlen @RWTH & @kutay_lab @ETH_en #CellBio2022 https://t.co/FqIRkKJXXC
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Mashup Score: 3Phase Separation during Germline Development - 1 year(s) ago
Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work has revealed crucial functions for phase separation during germline development. Phase separation controls the assembly and segregation of germ granules that determine which…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out this review in @CellReports "Phase Separation during Germline Development" by @SchuhLab et al. #CellBio2022 https://t.co/792zYTRalF
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Mashup Score: 1
Cell migration is essential for many biological processes, while abnormal cell migration is characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to-mesenchymal transition (EMT), and mesenchymal cells increase migration speed by adopting amoeboid features. This review highlights how amoeboid behaviour is not merely a migration mode but rather a cellular state –…
Source: Trends in Cell BiologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out this review by @VickySanzMoreno "The amoeboid state as part of the epithelial-to-mesenchymal transition programme", published in @TrendsCellBio #CellBio2022 https://t.co/Dbrvr6aMx8
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Check out this review "Shared genetic and epigenetic changes link aging and cancer" from @danielzabransky & @AshaniTW published in @TrendsCellBio #AACR23 https://t.co/UUajYk3YjX