• Mashup Score: 8
    Hox genes are critical regulators of periosteal stem cell identity - 1 year(s) ago

    Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is critical for the successful generation and application of future therapeutics. Here, we pinpoint Hox transcription factors as necessary and sufficient for periosteal stem cell function. Hox genes are transcriptionally enriched in…

    Source: The Company of Biologists
    Categories: General Medicine News, Latest Headlines
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      medical_xpress

      Genes that form specific bones in the womb heal them later in life, finds study @nyulangone https://t.co/y6cD6dAUgF https://t.co/b4ixsafYft

  • Mashup Score: 0
    Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling - 1 year(s) ago

    Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine(A) to inosine(I). A-to-I editing alters post-transcriptional RNA processing, making ADAR1 a critical regulator of gene expression. Consequently, Adar1 has been implicated in organogenesis. To determine the role of Adar1 in pancreatic development and homeostasis, we conditionally deleted Adar1 from the…

    Source: The Company of Biologists
    Categories: Hem/Oncs, Latest Headlines
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    • Profile photo of Aiims1742
      Aiims1742

      What role does Adar1 play in exocrine pancreatic development & homeostasis? Very nice study in an autochthonous model of Adar1 deletion by graduating @MDA_UTHGrad student Dhwani Rupani (McAllister Lab @MDAndersonNews) in @Dev_journal @DuctalvsAcinar https://t.co/Xeb8gpFBsn

  • Mashup Score: 1
    importance of stupidity in scientific research - 2 year(s) ago

    I recently saw an old friend for the first time in many years. We had been Ph.D. students at the same time, both studying science, although in different areas. She later dropped out of graduate school, went to Harvard Law School and is now a senior lawyer for a major environmental organization. At some point, the conversation turned to why she had left graduate school. To my utter astonishment,…

    Source: The Company of Biologists
    Categories: Healthcare Professionals, Latest Headlines
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      subatomicdoc

      RT @marianneaznar: @subatomicdoc I totally agree ! I often refer my students to this paper https://t.co/oBh9u25uu2 the phrasing is provoca…

  • Mashup Score: 0
    Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ) - 2 year(s) ago

    Summary: Here, we developed Transgene Electroporation in Adult Zebrafish (TEAZ), a method that enables researchers to study cancer and metastasis by introducing DNA elements focally into somatic adult tissue.

    Source: The Company of Biologists
    Categories: Latest Headlines, Oncologists1
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      whitefishlab

      This is a dream project I have wanted to do ever since I was a postdoc, but we never had quite the right technology. TEAZ turned out to be the technology, but needed a bit of tweaking from the original paper (https://t.co/YruISVDG9O) to make it way more efficient.

  • Mashup Score: 5
    importance of stupidity in scientific research - 2 year(s) ago

    I recently saw an old friend for the first time in many years. We had been Ph.D. students at the same time, both studying science, although in different areas. She later dropped out of graduate school, went to Harvard Law School and is now a senior lawyer for a major environmental organization. At some point, the conversation turned to why she had left graduate school. To my utter astonishment,…

    Source: The Company of Biologists
    Categories: Hospital-Based Medicine, Latest Headlines
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    • Profile photo of SapnaKmd
      SapnaKmd

      ‘Productive stupidity means being ignorant by choice. Focusing on impt ?s puts us in awkward position of ignorance.1 beautiful thing about #science.. allows us to bumble along, getting it wrong time after time, & feel fine as long as we learn something..’ https://t.co/LeNpoHlCXi

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