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Mashup Score: 7
Miriam Udler, MD, PhD, uses the Mass General Brigham Biobank for her diabetes research. Read about how studying this disease helps clinicians provide better care for their patients.
Source: www.massgeneralbrigham.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 12Use of Estonian Biobank data and participant recall to improve Wilson’s disease management - 3 day(s) ago
European Journal of Human Genetics – Use of Estonian Biobank data and participant recall to improve Wilson’s disease management
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet-
Genotype-first identification of Wilson’s Disease in the Estonian Biobank. 17 identified and only 8 previously diagnosed. Very high prevalence of neurodegenerative symptoms for those with WD genotypes https://t.co/LrCLNUs5gi @ejhg_journal https://t.co/XXqFIDwqVT
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Mashup Score: 11Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer - 7 day(s) ago
Broad and Mass General researcher Alexandra-Chloé Villani and Mass General oncologist Kerry Reynolds describe their pioneering effort to better understand, diagnose, and manage dangerous complications from cancer immunotherapy.
Source: www.broadinstitute.orgCategories: General Medicine News, CardiologistsTweet-
The interdisciplinary collaboration toward creative and impactful discoveries is what makes this place (& people) special. Great Q&A on this journey https://t.co/mVYWgs9rSs @broadinstitute https://t.co/TFZkz0tEeJ
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Mashup Score: 17A Polygenic Predictor of Baseline QTc is Associated With Sotalol-Induced QT Prolongation | Circulation - 9 day(s) ago
View all available purchase options and get full access to this article. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W; American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology. Prevention of torsade de pointes in hospital setting s: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010;55:934–947. doi: 10.1016/j.jacc.2010.01.001 Nauffal
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Polygenic predisposition to prolonged QTc among individuals with a normal baseline QTc predicted those having QTc prolongation after sotalol 80mg https://t.co/DktqTJVg5y @CircAHA @DrMegLancaster https://t.co/fQWJK2rGSN
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Mashup Score: 28Aspirin for Secondary Prevention of Atherosclerosis - 10 day(s) ago
Decades of recommendations to give aspirin for primary prevention of cardiovascular events, based on overoptimistic interpretation of inconclusive data, were recently overturned after a randomized clinical trial with approximately 100 000 person-years of follow-up found that aspirin increased…
Source: jamanetwork.comCategories: General Medicine News, CardiologistsTweet-
Thought-provoking editorial suggests we should reevaluate the recommendation for aspirin for chronic ASCVD https://t.co/TJePlL7hDJ @JAMACardio https://t.co/1ePMAEBcUI
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Mashup Score: 11
Background We examined the association between cannabis use and cardiovascular outcomes among the general population, among never‐tobacco smokers, and among younger individuals. Methods and Results…
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
In a large cross-sectional study of risk factors and outcomes (BRFSS), cannabis use was independently associated with increased odds of CVD in dose-dependent fashion, including among non-tobacco smokers https://t.co/aFGaiWBO4F @JAHA_AHA https://t.co/7KnPxxZh78
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Mashup Score: 1
Objectives To test whether haemochromatosis HFE C282Y homozygotes have increased risk of diabetes, liver disease, and heart disease even when they have normal plasma iron, transferrin saturation, or ferritin concentrations and to test whether C282Y homozygotes with diabetes, liver disease, or heart disease have increased mortality compared with non-carriers with these diseases. Design Prospective cohort study. Setting Three Danish general population cohorts: the Copenhagen City Heart Study, the Copenhagen General Population Study, and the Danish General Suburban Population Study. Participants 132 542 individuals genotyped for the HFE C282Y and H63D variants, 422 of whom were C282Y homozygotes, followed prospectively for up to 27 years after study enrolment. Main outcome measure Hospital contacts and deaths, retrieved from national registers, covering all hospitals and deaths in Denmark. Results Comparing C282Y homozygotes with non-carriers, hazard ratios were 1.72 (95% confidence inter
Source: www.bmj.comCategories: General Medicine News, CardiologistsTweet-
Intriguing but very small numbers - potentially high risk for diabetes for those with HFE C282Y homozygotes (genotype for hereditary hemochromatosis) but with normal ferritin or transferrin saturation. Oddly no signal when these are high. https://t.co/8ikma2lCOp @bmj_latest https://t.co/p3EXDMLhur
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Mashup Score: 5
BACKGROUND: Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and a potential target molecule. This study aimed to clarify whether a vaccine targeting FAP could eliminate myofibroblasts in chronic cardiac stress model mice and reduce cardiac fibrosis. METHODS: We coadministered a FAP peptide vaccine with a CpG K3 oligonucleotide adjuvant to male C57/BL6J mice and confirmed an elevation in the anti-FAP antibody titer. After continuous angiotensin II and phenylephrine administration for 28 days, we evaluated the degree of cardiac fibrosis and the number of myofibroblasts in cardiac tissues. RESULTS: We found that cardiac fibrosis was significantly decreased in the FAP-vaccinated mice compared with the angiotensin II and phenylephrine control mice (3.45±1.11% versus 8.62±4.79%; P=4.59×10−3) and that the accumulation of FAP-positive cells was also significan
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
Among mice continuously administered AngII/Epi, a fibroblast activation protein (FAP) vaccine mitigated cardiac fibrosis https://t.co/KTpGy3akNP @CircRes https://t.co/0KJZrwdtxd
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Mashup Score: 11Biden-Harris Administration Announces Action to Increase Access to Sickle Cell Disease Treatments | CMS - 14 day(s) ago
The Biden-Harris Administration announced today that sickle cell disease (SCD) will be the first focus of the Cell and Gene Therapy (CGT) Access Model, which was initially announced in February 2023. The model is designed to improve health outcomes, increase access to cell and gene therapies, and lower health care costs for some of the nation’s most vulnerable populations.
Source: www.cms.govCategories: General Medicine News, CardiologistsTweet-
Biden-Harris Administration Announces Action to Increase Access to Sickle Cell Disease Treatments https://t.co/n4fVPbW7m2 @CMSGov
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Mashup Score: 26Aspirin for Secondary Prevention of Atherosclerosis - 15 day(s) ago
Decades of recommendations to give aspirin for primary prevention of cardiovascular events, based on overoptimistic interpretation of inconclusive data, were recently overturned after a randomized clinical trial with approximately 100 000 person-years of follow-up found that aspirin increased…
Source: jamanetwork.comCategories: General Medicine News, CardiologistsTweet-
Thought-provoking editorial suggests we should reevaluate the recommendation for aspirin for chronic ASCVD https://t.co/TJePlL7hDJ @JAMACardio https://t.co/1ePMAEBcUI
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Nice summary about @MGHMedicine Endocrine investigators transforming type 2 diabetes classification and management studying the interplay of contributory genetic, environmental, and socioeconomic factors in the @MassGenBrigham Biobank https://t.co/Y1P7mnjCXv @miriam_udler… https://t.co/8pf6ply4hW https://t.co/j38YqeKC9e