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Mashup Score: 64Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course | Circulation: Genomic and Precision Medicine - 8 hour(s) ago
BACKGROUND: Earlier identification of high coronary artery disease (CAD) risk individuals may enable more effective prevention strategies. However, existing 10-year risk frameworks are ineffective at earlier identification. We sought to understand how the variable importance of genomic and clinical factors across life stages may significantly improve lifelong CAD event prediction. METHODS: A longitudinal study was performed using data from 2 cohort studies: the FOS (Framingham Offspring Study) with 3588 participants aged 19 to 57 years and the UKB (UK Biobank) with 327 837 participants aged 40 years to 70 years. A total of 134 765 and 3 831 734 person-time years were observed in FOS and UKB, respectively. Hazard ratios for CAD were calculated for polygenic risk score (PRS) and clinical risk factors at each age of enrollment. The relative importance of PRS and pooled cohort equations in predicting CAD events was also evaluated by age groups. RESULTS: The importance of CAD PRS diminished
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 12
Nature – Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet-
RT @vagheesh: AI is completely insane! (From the lab of this years winner of the Nobel prize) https://t.co/aQ0Zur5wSE
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Mashup Score: 12
Nature – Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet-
RT @vagheesh: AI is completely insane! (From the lab of this years winner of the Nobel prize) https://t.co/aQ0Zur5wSE
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Mashup Score: 3Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: A Pilot Randomized Controlled Trial | Circulation - 9 day(s) ago
View all available purchase options and get full access to this article. Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim S-Y, Zannad F. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J. 2013;34:2453–2463. doi: 10.1093/eurheartj/eht187 Agarwal R, Ruilope LM, Ruiz-Hurtado G, Haller
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
In a pilot open-label RCT of N=8 with primary aldosteronism and BP >140/90 randomized to finerenone v spironolactone had no significant difference in mean daytime SBP on 24h ambulatory BP monitor at d56 but maybe more favorable safety endpts https://t.co/HVWCDROMFz @CircAHA https://t.co/Vf2mgx7Vab
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Mashup Score: 2
The agency issued designs for front-of-package lists that food companies would be required to include.
Source: www.nytimes.comCategories: General Medicine News, CardiologistsTweet-
More context for Nutrition Labels so consumers can more easily make informed decisions regarding saturated fat, sodium, and added sugars https://t.co/SXL8gYkfNQ @nytimes https://t.co/HZxLwGF8rv
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Mashup Score: 3Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: A Pilot Randomized Controlled Trial | Circulation - 9 day(s) ago
View all available purchase options and get full access to this article. Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim S-Y, Zannad F. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J. 2013;34:2453–2463. doi: 10.1093/eurheartj/eht187 Agarwal R, Ruilope LM, Ruiz-Hurtado G, Haller
Source: www.ahajournals.orgCategories: General Medicine News, CardiologistsTweet-
In a pilot open-label RCT of N=8 with primary aldosteronism and BP >140/90 randomized to finerenone v spironolactone had no significant difference in mean daytime SBP on 24h ambulatory BP monitor at d56 but maybe more favorable safety endpts https://t.co/HVWCDROMFz @CircAHA https://t.co/Vf2mgx7Vab
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Mashup Score: 26Heart Failure with Preserved Ejection Fraction | NEJM - 13 day(s) ago
Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors.
Source: www.nejm.orgCategories: General Medicine News, CardiologistsTweet-
High yield HFpEF review https://t.co/oIZt5R7t8g @NEJM https://t.co/Vx48btmjOg
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Mashup Score: 24Heart Failure with Preserved Ejection Fraction | NEJM - 14 day(s) ago
Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors.
Source: www.nejm.orgCategories: General Medicine News, CardiologistsTweet-
High yield HFpEF review https://t.co/oIZt5R7t8g @NEJM https://t.co/Vx48btmjOg
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Mashup Score: 17Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial - 14 day(s) ago
AbstractBackground and Aims. Moderate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine
Source: academic.oup.comCategories: General Medicine News, CardiologistsTweet-
In the PREDIMED trial, urinary tartaric acid (as a measure of red wine consumption) analysis shows an association between light-to-moderate wine consumption & reduced CV risk https://t.co/QS9V4dQfjp @ESC_Journals https://t.co/nW8PTTIS4u
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Mashup Score: 30
Nature – Tabular Prior-data Fitted Network, a tabular foundation model, provides accurate predictions on small data and outperforms all previous methods on datasets with up to 10,000 samples by a…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet-
A new AI model for your spreadsheet needs https://t.co/rZZ5wtdqyE @Nature https://t.co/vjdBNRbvCi
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Delighted to share our study by @tigerstatdoc with @aklfahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events https://t.co/oLRpkE3cNW @Circ_Gen https://t.co/TJIVDbhKUC