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Mashup Score: 0
We identified 45 viral exposures significantly associated with increased risk of neurodegenerative disease and replicated 22 of these associations, including the association between the Epstein-Barr virus and multiple sclerosis. As vaccines are available for some of the associated viruses, vaccination may be a way to reduce risk of neurodegenerative disease.
Source: NeuronCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 1Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity - 1 year(s) ago
Rosenberg et al. reveal a potential mechanism by which cannabidiol (CBD) reduces seizures. They discover that CBD restores the hippocampal excitatory-to-inhibitory ratio by preventing the actions of the lipid LPI at the receptor GPR55. Seizures acutely potentiate the GPR55-LPI axis, providing a target for CBD’s anti-seizure action.
Source: NeuronCategories: General Medicine News, Latest HeadlinesTweet-
"Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity" @NYULH_Neuro Richard Tsien Read more in @NeuroCellPress: https://t.co/rBpYXpzpl1
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Mashup Score: 5Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity - 1 year(s) ago
Rosenberg et al. reveal a potential mechanism by which cannabidiol (CBD) reduces seizures. They discover that CBD restores the hippocampal excitatory-to-inhibitory ratio by preventing the actions of the lipid LPI at the receptor GPR55. Seizures acutely potentiate the GPR55-LPI axis, providing a target for CBD’s anti-seizure action.
Source: NeuronCategories: General Medicine News, Latest HeadlinesTweet-
"Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity" @NYULH_Neuro Richard Tsien Read more in @NeuroCellPress: https://t.co/rBpYXpzpl1
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Mashup Score: 1Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects - 1 year(s) ago
In this article, 433 iPSCs from control and ALS patients were differentiated into motor neurons and profiled by immunocytochemistry and RNA-seq. Results reveal sex and cell composition to be among the strongest drivers of gene expression variation, with a higher percentage of Islet1+ cells observed in male ALS patient-derived cultures.
Source: NeuronCategories: Latest Headlines, NeurologyTweet-
“Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects” by Clive Svendsen et al. Neuron https://t.co/ox0dg6Jgin
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Mashup Score: 1Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency - 1 year(s) ago
Individuals with neurodevelopmental disorders present with wide variability in symptoms, which can be modified by their unique combination of genetic variants. Tabbaa et al. reveal that studying genetic mutations in an ASD-risk gene (Chd8) across many genetically diverse mouse strains recapitulates individual differences in symptom occurrence, manifestation, and severity.
Source: NeuronCategories: Future of Medicine, Latest HeadlinesTweet-
Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency https://t.co/h4CqqO0RS8
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Mashup Score: 7Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning - 1 year(s) ago
The coincidence time window is the maximal temporal interval that allows two stimuli to be associated in Pavlovian learning. However, its neuronal mechanism remains unclear. Zeng et al. identify a serotonergic circuitry that regulates the coincidence time window for Drosophila olfactory learning, shedding light on the mystery left by Ivan Pavlov.
Source: NeuronCategories: Future of Medicine, Latest HeadlinesTweet-
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning https://t.co/B6S4kc4VdL
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Mashup Score: 1
Berendzen et al. report the surprising finding that prairie voles lacking the oxytocin receptor (Oxtr) display pair-bonding and parental behaviors, including nursing. Despite many pharmacological studies suggesting a requirement for Oxtr, these findings indicate that Oxtr is genetically dispensable for pair-bond formation and parental behaviors in voles.
Source: NeuronCategories: General Medicine News, Latest HeadlinesTweet-
Prairie voles can form pair-bonds and rear pups without oxytocin receptor signaling, contrary to decades of research stating otherwise. Read more in @NeuroCellPress: https://t.co/4SmIQ4N33I @LabManoli @Shah_Laboratory https://t.co/pHKJshdGmu
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Mashup Score: 34
Berendzen et al. report the surprising finding that prairie voles lacking the oxytocin receptor (Oxtr) display pair-bonding and parental behaviors, including nursing. Despite many pharmacological studies suggesting a requirement for Oxtr, these findings indicate that Oxtr is genetically dispensable for pair-bond formation and parental behaviors in voles.
Source: NeuronCategories: Future of Medicine, Latest HeadlinesTweet-
RT @LomvardasLab: Oxytocin receptor is not required for social attachment in prairie voles https://t.co/8ppzcoP0ud The tragedy of Science…
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Mashup Score: 11
Berendzen et al. report the surprising finding that prairie voles lacking the oxytocin receptor (Oxtr) display pair-bonding and parental behaviors, including nursing. Despite many pharmacological studies suggesting a requirement for Oxtr, these findings indicate that Oxtr is genetically dispensable for pair-bond formation and parental behaviors in voles.
Source: NeuronCategories: General Medicine News, Latest HeadlinesTweet-
Prairie voles can form pair-bonds and rear pups without oxytocin receptor signaling, contrary to decades of research stating otherwise. Read more in @NeuroCellPress: https://t.co/4SmIQ4N33I @LabManoli @Shah_Laboratory https://t.co/EUHCs3MuTD
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Mashup Score: 10
We identified 45 viral exposures significantly associated with increased risk of neurodegenerative disease and replicated 22 of these associations, including the association between the Epstein-Barr virus and multiple sclerosis. As vaccines are available for some of the associated viruses, vaccination may be a way to reduce risk of neurodegenerative disease.
Source: NeuronCategories: Expert Picks, Latest HeadlinesTweet-
22 viral infections associated with neurodegenerative disease. The largest effect association was between viral encephalitis exposure and #Alzheimer’s disease. Influenza with pneumonia was significantly associated with 5 of 6 neurodegenerative diseases https://t.co/5Vc0Gvb0h2
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Not “ just” for COVID? Virus exposure and neurodegenerative disease risk across national biobanks finds positive associations for several viruses. Food for epidemiology specialists https://t.co/Xzz9ihFN32