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Mashup Score: 7Single-fraction Radiation Treatment Dose Response in a Genetically Engineered Mouse Model of Medulloblastoma - 6 month(s) ago
Medulloblastoma is the most common malignant brain tumor of children. Although standard of care radiotherapy for pediatric medulloblastoma (PM) can lead to long-term remission or cure in many patients, it can also cause life-long cognitive impairment and other adverse effects. The pathophysiological mechanisms involved in radiation-induced cerebral damage are incompletely understood, and their elucidation may lead to interventions that mitigate radiation toxicity. To explore the mechanisms of radiation-induced cerebral damage, transgenic mouse models of PM and non-tumor-bearing controls were exposed to radiation doses that ranged from 0 to 30 Gy. Between 0–20 Gy, a significant dose-dependent reduction in tumor-associated hydrocephalus and increase in overall survival were observed. However, at 30 Gy, hydrocephalus incidence increased and median overall survival fell to near-untreated levels. Immunohistochemistry revealed that both tumor-bearing and non-tumor-bearing mice treated with 3
Source: meridian.allenpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1Inflammatory Pathways and Their Implications in Heart Failure With Preserved Ejection Fraction - 6 month(s) ago
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome characterized by elevated left ventricular (LV) stiffness and filling pressures, despite normal or near-normal EFs. It accounts for approximately half of all HF cases and has become increasingly prevalent with an aging population.1 In contrast to HF with reduced EF, HFpEF is less understood, and options for effective treatment are limited.2 Recent evidence suggests that systemic inflammation plays a pivotal role in HFpEF pathophysiology.3Historically, the pathophysiologic mechanisms of HFpEF have been attributed primarily to diastolic dysfunction and abnormal ventricular-arterial coupling.4 This paradigm falls short, however, in explaining the full spectrum of clinical manifestations of HFpEF. Although inflammation’s role in HFpEF has been increasingly recognized, the understanding of the mechanistic link between systemic inflammation and the development of HFpEF is still limited. Much of the current understan
Source: meridian.allenpress.comCategories: General Medicine News, Cardiology News and JournTweet-
RT @KeriSprung: Inflammatory Pathways and Their Implications in Heart Failure With Preserved Ejection Fraction https://t.co/jCI10Uq85A @Tex…
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Mashup Score: 1New Biomarkers for Cardiovascular Disease - 6 month(s) ago
Abstract. Cardiovascular disease is the leading cause of death and disability worldwide. Early detection and treatment of cardiovascular disease are crucial for patient survival and long-term health. Despite advances in cardiovascular disease biomarkers, the prevalence of cardiovascular disease continues to increase worldwide as the global population ages. To address this problem, novel biomarkers that are more sensitive and specific to cardiovascular diseases must be developed and incorporated into clinical practice. Exosomes are promising biomarkers for cardiovascular disease. These small vesicles are produced and released into body fluids by all cells and carry specific information that can be correlated with disease progression. This article reviews the advantages and limitations of existing biomarkers for cardiovascular disease, such as cardiac troponin and cytokines, and discusses recent evidence suggesting the promise of exosomes as cardiovascular disease biomarkers.
Source: meridian.allenpress.comCategories: General Medicine News, Cardiology News and JournTweet-
RT @KeriSprung: New Biomarkers for Cardiovascular Disease https://t.co/ndJcbXKJ7q @Texas_Heart
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Mashup Score: 102How to Build a Successful Phase I Clinical Trials Unit: Lessons Based on the MD Anderson Cancer Center Experience - 6 month(s) ago
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA WIN Consortium, Paris, France University of Nebraska, Omaha, NB, USA Department of Investigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX, USA Razelle Kurzrock, David Hong; How to Build a Successful Phase I Clinical Trials Unit: Lessons Based on the MD Anderson Cancer Center Experience. Journal of Immunotherapy and Precision Oncology 2023; doi: https://doi.org/10.36401/JIPO-23-243 This content is only available
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
👉How to Build a Successful Phase I Clinical Trials Unit: Lessons Based on the MD Anderson Cancer Center Experience | Journal of Immunotherapy and Precision Oncology 🫵Many of our points are not intuitive. 💥☄️Conventional wisdom not always correct. https://t.co/fgmKbqKC4h
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Mashup Score: 38
Abstract. The clinical approach to undifferentiated shock in critically ill patients should be revised to use modern, point-of-care tools that are readily available. With the increasing availability of 2-dimensional ultrasonography and advanced Doppler capabilities, a quick, simplified, and integrated stepwise approach to shock using critical care echocardiography is proposed. Evidence supports the feasibility and usefulness of critical care echo-cardiography in enhancing diagnostic accuracy for shock, but there is a lack of systematic application of the technology in patients with undifferentiated shock. The proposed approach begins with the use of noninvasive ultrasonography with pulsed-wave Doppler capability to determine the flow state by measuring the velocity time integral of the left ventricular outflow tract. This narrative review explores the use left ventricular outflow tract velocity time integral, velocity time integral variation, limited visceral organ Doppler, and lung ul
Source: meridian.allenpress.comCategories: General Medicine News, Cardiologists1Tweet-
RT @Serginho1409: Echocardiography—Driven Approach to Undifferentiated Shock https://t.co/4C2mLzibYZ #echofirst #echocardio #CardioEd #Car…
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Mashup Score: 37Unicentric Castleman Disease: Illustration of Its Morphologic Spectrum and Review of the Differential Diagnosis - 7 month(s) ago
Context.—. Unicentric Castleman disease (UCD) is a dynamic entity with a wide spectrum of morphologic findings. UCD can be further subdivided into hyaline-vascular and mixed/plasmacytic variants. Hyaline-vascular UCD has both follicular and interfollicular (stromal) changes, and occasionally these lesions show a skewed representation of either the follicular or stromal compartments. Plasmacytosis is usually minimal in hyaline-vascular variant. Mixed/plasmacytic variant of UCD is composed of sheets of plasma cells often associated with a variable number of follicles with regressive changes.Objective.—. To illustrate the differential diagnosis of UCD, as it is quite broad and includes lymphomas, plasma cell neoplasms and stromal neoplasms such as follicular dendritic cell sarcoma and vascular neoplasms, immunoglobulin G4–related disease, infections, and other rare lesions. An additional objective is to enhance awareness of the morphologic features of UCD in excisional and in small core-n
Source: meridian.allenpress.comCategories: General Medicine News, Hem/OncsTweet-
RT @SibaElHussein: Illustration of the morphologic spectrum of Unicentric Castleman Disease ➡️https://t.co/JEW5THjGlz @ArchivesPath #hemep…
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Mashup Score: 3Comparing Two Methods for Estimating Network Size - 8 month(s) ago
In this paper we compare two methods for estimating the size of personal networks using a nationally representative sample of the United States. Both methods rely on the ability of respondents to estimate the number of people they know in specific subpopulations of the U.S. (e.g., diabetics, Native Americans) and people in particular relation categories (e.g., immediate family, coworkers). The results demonstrate a remarkable similarity between the average network size generated by both methods (approximately 291). Similar results were obtained with a separate national sample. An attempt to corroborate our estimates by replication among a population we suspect has large networks (clergy), yielded a larger average network size. Extensive investigation into the existence of response effects showed some preference for using certain numbers when making estimates, but nothing that would significantly affect the estimate of network size beyond about 6 percent. We conclude that both methods f
Source: meridian.allenpress.comCategories: Infectious Disease, Latest HeadlinesTweet-
Now, we need a denominator. There is a fairly extensive literature on the mean size of social networks of 'meaningful contacts'. There is no absolute consensus, but most estimates are around ~300. I'll use 291 as estimated in the classical paper below. 8/ https://t.co/Cmjkce5TFy
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Mashup Score: 1Clinical Predictors and Outcomes After Left Ventricular Assist Device Implantation and Tracheostomy - 9 month(s) ago
AbstractBackground. Postoperative respiratory failure is a major complication that affects up to 10% of patients who undergo cardiac surgery and has a high in-hospital mortality rate. Few studies have investigated whether patients who require tracheostomy for postoperative respiratory failure after continuous-flow left ventricular assist device (CF-LVAD) implantation have worse survival outcomes than patients who do not.Objective. To identify risk factors for respiratory failure necessitating tracheostomy in CF-LVAD recipients and to compare survival outcomes between those who did and did not require tracheostomy.Methods. Consecutive patients who underwent primary CF-LVAD placement at a single institution between August 1, 2002, and December 31, 2019, were retrospectively reviewed. Propensity score matching accounted for baseline differences between the tracheostomy and nontracheostomy groups. Multivariate logistic regression was used to identify tracheostomy risk factors and 90-day su
Source: meridian.allenpress.comCategories: Cardiologists, Latest HeadlinesTweet-
RT @SXC71: Preop optimization key when looking at Outcomes After LVAD Implantation and Tracheostomy https://t.co/t0Nm49a52P @BCM_Surgery @…
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Mashup Score: 2
Mitral and tricuspid valvular disease have been managed surgically; however, multiple transcatheter technologies have diversified the therapeutic arsenal and expanded the number of patients eligible for treatment. These new technologies and active trials currently being performed at The Texas Heart Institute will be highlighted.Transcatheter edge-to-edge repair (TEER) with MitraClip (Abbott Structural Heart) plays an important role in the management of degenerative and functional mitral regurgitation (MR). Despite its success, the limitations of MitraClip include challenging anatomy that may not be amenable to TEER, the common need for multiple devices, risk of device-related mitral stenosis, and a not-trivial rate of residual MR.1 Delivered via a 22F sheath, the PASCAL device (Edwards Lifesciences) offers several improvements.2 Its 3-catheter system (including a guide, steerable, and implantation catheter) offers easy maneuverability in 3 independent planes. It has a spacer that fills
Source: meridian.allenpress.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Cutting-edge trials in structural heart disease at The Texas Heart Institute | #THIPubs #GVSilva | @Texas_Heart #THIJournal https://t.co/EHxB1llQzQ
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Mashup Score: 0Taking Back Sunday - 9 month(s) ago
1 Department of Medicine, Intermountain Medical Center, Intermountain Health, Murray, UT, USA This content is only available as a PDF. Source of Support: None. Conflict of Interest: None. Lewis MA. Taking back Sunday. This work is published under a CC-BY-NC-ND 4.0 International License. This site uses cookies. By continuing to use our website, you are agreeing to our privacy
Source: meridian.allenpress.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Taking Back Sunday https://t.co/uf6Wxff3Xk @OncoAlert @OncLive @JIPOEditors @JQSHEditors #burnout
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Single-fraction Radiation Treatment Dose Response in a Genetically Engineered Mouse Model of Medulloblastoma | Radiation Research https://t.co/s0CTfQtyG2