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    Discovering the brakes/checkpoints that cancer places on the immune system to prevent being eradicated led to the 2018 Nobel Prize and the development of multiple Food and Drug Administration-approved immune checkpoint inhibitors (ICIs). ICIs have transformed the treatment of numerous cancer types a …

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    • Immune checkpoint inhibitors amongst best drugs ever. Nobel Prize. End-stage cancers can be cured. But they can also cause dramatically accelerated progression pace (hyperprogression) especially in presence of EGFR alterations or MDM2 amplification https://t.co/X7p3dRpUc6 https://t.co/C5yXnc7VT0