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Mashup Score: 2
De-Shen Wang and colleagues evaluate the efficacy and safety of cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as a conversion regimen in CRC patients with initially unresectable colorectal liver metastases.
Source: journals.plos.orgCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 1
Applying a positive outlier lens is one effective approach for generating evidence to inform global health policy, program, and funding decisions. Exemplars in Global Health (EGH) is a program that studies positive outlier countries that have made extraordinary progress in health outcomes (despite limited resources) and disseminates their successes through multiple types of outputs. To date, EGH has studied, or is studying, 14 global health topics in 28 countries. This paper aims to identify findings, summarized as themes and sub-themes, that appear among all completed EGH studies. We developed a conceptual framework and used a content analysis approach to identify the top thematic areas that appear as drivers for programmatic success across EGH studies that were completed between June 2020-May 2023. The EGH studies (N = 31) spanned six topics including under-five child mortality (n = 6), childhood stunting (n = 5), community health workers (CHW) (n = 4), vaccine delivery (n = 3), COVI
Source: journals.plos.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 5
Using a novel modelling approach, Mousa and colleagues investigate the design and analysis of malaria chemoprevention trials and generate measures of protection that can be applied across a range of transmission settings.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Paucity of intellectual property rights information in the US biologics system a decade after passage of the Biosimilars Act - 2 day(s) ago
In this Policy Forum piece, Robin Feldman discusses how current legislation contributes to informational deficits around drug patents for biologic drugs in the United States.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 14
Objective The purpose of this study was to examine the long-term effects of time-restricted eating (TRE), with or without high intensity functional training (HIFT), on body composition and cardiometabolic biomarkers among inactive women with obesity. Methods Sixty-four women (BMI = 35.03 ± 3.8 kg/m2; age = 32.1 ± 10 years) were randomly allocated to either: (1) TRE (≤8-h daily eating window, with ad libitum energy intake) group; (2) HIFT (3 sessions/week) group; or (3) TRE combined with HIFT (TRE-HIFT) group. The interventions lasted 12 weeks with a pre-post measurement design. A HIFT session consists of 8 sets of multiple functional exercises with self-selected intensity (20 or 30s work/10s rest). Results TRE-HIFT showed a greater decrease of waist and hip circumferences and fat mass compared to TRE (p = 0.02, p = 0.02 and p<0.01; respectively) and HIFT (p = 0.012, p = 0.028 and p<0.001; respectively). Weight and BMI decreased in TRE-HIFT compared to HIFT group (p<0.001; for both). Fa
Source: journals.plos.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Protracted development of stick tool use skills extends into adulthood in wild western chimpanzees - 4 day(s) ago
Tool use is considered a driving force behind the evolution of brain expansion and prolonged juvenile dependency in the hominin lineage. A study of stick tool use in wild chimpanzees reveals a prolonged time for cognitive assimilation, suggesting selection pressure that favors retention of learning capacities into adulthood.
Source: journals.plos.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 1
Thuy Doan and co-workers explore the impact of mass azithromycin distribution on the antibiotic resistance in the gut of Nigerien pre-school children.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 12
Binh Nguyen and colleagues, use longitudinally collected data and target trial emulation methods to explore the impact of mid-life physical activity on the health outcomes of Australian women later in life.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet-
Binh Nguyen and team, use longitudinally collected data and target trial emulation methods to explore the impact of mid-life physical activity on the health outcomes of Australian women later in life. @DrMelodyDing @pjclare @GregoreMielke @ProfWendyBrown https://t.co/pae5f7yEM3 https://t.co/mQmVlOL5yR
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Mashup Score: 184
Anthony Civitarese and colleagues observed an increase in mitochondrial DNA in muscle and a decrease in whole body oxygen consumption in healthy adults who underwent caloric restriction.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 12
Binh Nguyen and colleagues, use longitudinally collected data and target trial emulation methods to explore the impact of mid-life physical activity on the health outcomes of Australian women later in life.
Source: journals.plos.orgCategories: General Medicine News, General HCPsTweet-
Binh Nguyen and team, use longitudinally collected data and target trial emulation methods to explore the impact of mid-life physical activity on the health outcomes of Australian women later in life. @DrMelodyDing @pjclare @GregoreMielke @ProfWendyBrown https://t.co/pae5f7yEM3 https://t.co/mQmVlOL5yR
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De-Shen Wang and colleagues evaluate the efficacy and safety of cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as a conversion regimen in CRC patients with initially unresectable colorectal liver metastases. #clinicaltrial #colorectalcancer 🔬: https://t.co/LDd9mjfNkn https://t.co/SkGw4P3ad5