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Mashup Score: 0Acquisition of a multibasic cleavage site does not increase MERS-CoV entry into Calu-3 human lung cells | Journal of Virology - 3 month(s) ago
The highly cleavable furin motif in the spike protein is required for robust lung cell entry, transmission, and pathogenicity of SARS-CoV-2. In contrast, it is unknown whether optimization of the furin motif in the spike protein of the pre-pandemic MERS-…
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 93The Brief Case: Sister Fungi in a Patient with AIDS | Journal of Clinical Microbiology - 3 month(s) ago
A 30-year-old female with advanced human immunodeficiency virus (HIV) type 1 infection was transferred to our institution for evaluation of persistent cough and recurrent fevers of unknown origin. She had immigrated from the Philippines to the United States 3 years ago and first came to medical attention at an outside institution 12 weeks prior to current presentation after experiencing 2 months of cough, night sweats, and fevers. Testing at that time revealed Pneumocystis jirovecii pneumonia (PJP) and HIV infection, with an HIV load of 210,000 copies/mL and a CD4 T lymphocyte count of 13 cells/μL (reference range, 500 to 1,200 cell/μL). She was hospitalized for 7 days and treated with trimethoprim-sulfamethoxazole and prednisone for PJP, which was later switched to atovaquone after she developed acute kidney injury (AKI). She was also started on a combination antiretroviral therapy (ART) of bictegravir, emtricitabine, and tenofovir alafenamide for HIV infection.
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
#MayoIDCase #IDBR Young woman, HIV, CD4 13, recent PJP & CMV retinitis CC: dyspnea, fever, renal failure. Kidney histopathology: tubules containing small Gram-positive spores (A) that are focally acid-fast (B). What is your differential diagnosis? https://t.co/T336MxjRsn https://t.co/BMyLnMxlOF
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Mashup Score: 10Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity | Journal of Virology - 3 month(s) ago
This study shows how herpes simplex virus type 1 (HSV-1) spreads within the brain after infecting the nasal passages. Our data reveal the distinct pattern of HSV-1 through the brain during a non-encephalitic infection. Furthermore, microglial activation …
Source: journals.asm.orgCategories: General Medicine News, NeurologyTweet-
“Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity” by Christy Niemeyer et al. Journal of Virology https://t.co/VPepdgMcza
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Mashup Score: 84The Brief Case: Sister Fungi in a Patient with AIDS | Journal of Clinical Microbiology - 3 month(s) ago
A 30-year-old female with advanced human immunodeficiency virus (HIV) type 1 infection was transferred to our institution for evaluation of persistent cough and recurrent fevers of unknown origin. She had immigrated from the Philippines to the United States 3 years ago and first came to medical attention at an outside institution 12 weeks prior to current presentation after experiencing 2 months of cough, night sweats, and fevers. Testing at that time revealed Pneumocystis jirovecii pneumonia (PJP) and HIV infection, with an HIV load of 210,000 copies/mL and a CD4 T lymphocyte count of 13 cells/μL (reference range, 500 to 1,200 cell/μL). She was hospitalized for 7 days and treated with trimethoprim-sulfamethoxazole and prednisone for PJP, which was later switched to atovaquone after she developed acute kidney injury (AKI). She was also started on a combination antiretroviral therapy (ART) of bictegravir, emtricitabine, and tenofovir alafenamide for HIV infection.
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
#MayoIDCase #IDBR Young woman, HIV, CD4 13, recent PJP & CMV retinitis CC: dyspnea, fever, renal failure. Kidney histopathology: tubules containing small Gram-positive spores (A) that are focally acid-fast (B). What is your differential diagnosis? https://t.co/T336MxjRsn https://t.co/BMyLnMxlOF
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Mashup Score: 21
Our study addresses a significant knowledge gap in the clinical management of this non-Candida albicans species. Our retrospective review includes comprehensive AST data for 112 Candida guilliermondii isolates, which is the largest number of isolates …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
Publication Alert Candida guilliermondii fungemia: a 12-year review of antimicrobial susceptibility patterns at a reference laboratory and tertiary care center. Congratulations Drs. @jamchugh @IDdocAdi @NischalR3 @stevens_AK https://t.co/jukFrT7ylf
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Mashup Score: 4
A 72-year-old man from rural Minnesota presented to the emergency department in November 2023 with a 4-day history of fever, chills, vomiting, diarrhea, cough, and shortness of breath. He had underlying sarcoidosis, bronchiectasis, paroxysmal atrial fibrillation, and sinus bradycardia and had a pacemaker in place. He reported extensive zoonotic exposures in Minnesota during the 2 weeks before presentation, including deer hunting until 5 days before the symptom onset, consumption of cooked game meat, and freshwater exposure. In addition, on the day of symptom onset, he had manually removed and discarded two engorged ticks from his abdomen. In the emergency department, he was febrile and developed atrial fibrillation with rapid ventricular response and hypotension. Because of the concern for sepsis, he was given intravenous cefepime, vancomycin, and metronidazole, and oral doxycycline; 4 h after administration of this antimicrobial regimen, he developed severe hemodynamic instability. Hy
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
PCR / molecular test of the blood has highest sensitivity for diagnosis of leptospirosis in a patient within 6 days of symptoms in whom serology is still negative. You can read more of leptospirosis and this case report of our fellow Dr MJ Kim here: https://t.co/87Xl7HKObV
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Mashup Score: 3
A 72-year-old man from rural Minnesota presented to the emergency department in November 2023 with a 4-day history of fever, chills, vomiting, diarrhea, cough, and shortness of breath. He had underlying sarcoidosis, bronchiectasis, paroxysmal atrial fibrillation, and sinus bradycardia and had a pacemaker in place. He reported extensive zoonotic exposures in Minnesota during the 2 weeks before presentation, including deer hunting until 5 days before the symptom onset, consumption of cooked game meat, and freshwater exposure. In addition, on the day of symptom onset, he had manually removed and discarded two engorged ticks from his abdomen. In the emergency department, he was febrile and developed atrial fibrillation with rapid ventricular response and hypotension. Because of the concern for sepsis, he was given intravenous cefepime, vancomycin, and metronidazole, and oral doxycycline; 4 h after administration of this antimicrobial regimen, he developed severe hemodynamic instability. Hy
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
PCR / molecular test of the blood has highest sensitivity for diagnosis of leptospirosis in a patient within 6 days of symptoms in whom serology is still negative. You can read more of leptospirosis and this case report of our fellow Dr MJ Kim here: https://t.co/87Xl7HKObV
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Mashup Score: 58GPT-4-based AI agents—the new expert system for detection of antimicrobial resistance mechanisms? | Journal of Clinical Microbiology - 4 month(s) ago
The study titled “GPT-4-based AI agents—the new expert system for detection of antimicrobial resistance mechanisms?” is critically important as it explores the integration of advanced artificial intelligence (AI) technologies, like generative pre-trained …
Source: journals.asm.orgCategories: General Medicine News, Expert PicksTweet-
There's a pressing need to improve the efficiency of accurately detecting antimicrobial resistance. How about generative #AI? https://t.co/YDG5rFhXtF A problem of over-flagging, for now https://t.co/gthjEWO17F
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Mashup Score: 48The mammary glands of cows abundantly display receptors for circulating avian H5 viruses | Journal of Virology - 4 month(s) ago
H5N1 influenza viruses, which usually affect birds, have been found on dairy farms in the USA. Surprisingly, these viruses are spreading among dairy cows, and there is a possibility that they do not spread through the air but through their milk glands. To …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
The mammary glands of cows abundantly display receptors for circulating avian H5 viruses | Journal of Virology https://t.co/StshrtZDK5
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Mashup Score: 0Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry | mBio - 4 month(s) ago
Enveloped viruses cause a wide range of diseases in humans. At the first step of infection, these viruses must fuse their envelope with a cell membrane to initiate infection. This fusion is mediated by viral proteins that require a critical activating …
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet-
Dr. @mosconaporotto's lab shows that the F proteins of field strains have a different cleavage motif from laboratory-adapted strains and are cleaved by unidentified proteases expressed in only a narrow subset of cell types. @mbiojournal | https://t.co/01ByDN9TsI https://t.co/SNoOY99Ovt
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😷 By employing pseudotyped particles, scientists investigated whether augmented cleavage at the S1/S2 site also increases #MERS-CoV entry into Calu-3 human #lung cells. 👉 https://t.co/u0oJWlJXrT https://t.co/33uCyjiGPv