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Mashup Score: 1JCI Insight - LSD1 promotes prostate cancer cell reprogramming by repressing TP53 signaling independently of its demethylase function - 10 month(s) ago
ResearchIn-Press PreviewOncology Open Access | 10.1172/jci.insight.167440 Zhi Duan,2 Diana Flores,1 Chao Zhang,1 Archana Sehrawat,3 Ya-Mei Hu,4 Olivia A. Swaim,1 Eva Rodansky,1 William K. Storck,1 Joshua A. Kuleape,1 Karan Bedi,5 Rahul Mannan,6 Xiao-Ming Wang,6 Aaron M. Udager,6…
Source: insight.jci.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2JCI Insight - Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program - 11 month(s) ago
Human CD8+ T cells differentiated in hypoxia and TGF-β1 acquire a TRM phenotype. The necessity of TGF-β in TRM formation is well documented, but additional cues are required, as TGF-β alone is not sufficient to induce TRM phenotype (4, 8). Previous studies in mouse splenocytes demonstrated a role for inflammatory cytokines in TRM phenotype induction when used in combination with TGF-β (4, 10)….
Source: insight.jci.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
Don’t know whom or what I’ve been spamming but maybe this is a sign I should start - “ This ONE SIMPLE TRICK can make millions of resident memory T cells ..” https://t.co/qncgYPebMH https://t.co/M1GdcWZLND
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Mashup Score: 12JCI Insight - Targeted regulation of TAK1 counteracts dystrophinopathy in a DMD mouse model - 12 month(s) ago
TAK1 is activated in dystrophic muscle of mdx mice. By performing immunoblotting, we first investigated how the levels of TAK1 change with age in the skeletal muscle of dystrophin-deficient mdx mice compared with WT mice. There was a significant increase in the levels of phosphorylated TAK1 (p-TAK1) and total TAK1 protein in the gastrocnemius (GA) muscle of 4-week-old mdx mice compared with…
Source: insight.jci.orgCategories: General Medicine News, Latest HeadlinesTweet-
Researchers target protein that can slow down muscular dystrophy @JCI_Insight https://t.co/lbkSOExM85 https://t.co/SpjfPBLvLM
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Mashup Score: 2JCI Insight - Prospective assessment of risk biomarkers of sinusoidal obstruction syndrome after hematopoietic cell transplantation - 12 month(s) ago
Clinical MedicineOncologyTransplantation Open Access | 10.1172/jci.insight.168221 Alan Bidgoli,2 Brittany P. DePriest,2 Alejandra Méndez,3 Khadijeh Bijangi-Vishehsaraei,3 Evelio D. Perez-Albuerne,4 Robert A. Krance,5 Jamie Renbarger,3 Jodi L. Skiles,3 Sung W. Choi,6 Hao Liu,1,7 and Sophie…
Source: insight.jci.orgCategories: General Medicine News, Latest HeadlinesTweet-
Risk biomarkers could predict serious side effect of #stemcelltransplant @MUSCHealth @JCI_Insight https://t.co/DZikvS20cz https://t.co/10KMszXWPC
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Mashup Score: 1JCI Insight - Beta-cell function after Roux-en-Y gastric bypass surgery or reduced energy intake alone in people with obesity - 12 month(s) ago
BACKGROUND/AIMS. The effects of diet-induced weight loss (WL) and WL after Roux-en-Y gastric bypass (RYGB) surgery on β-cell function are unclear because of conflicting results from different studies, presumably because of differences in the methods used to measure β-cell function, the amount of WL between treatment groups, and baseline β-cell function. The goal of this study was to evaluate the…
Source: insight.jci.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
Beta-cell function after Roux-en-Y gastric bypass surgery or reduced energy intake alone in people with obesity https://t.co/IvElXQoMXz
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Mashup Score: 0JCI Insight - Beta-cell function after Roux-en-Y gastric bypass surgery or reduced energy intake alone in people with obesity - 1 year(s) ago
BACKGROUND/AIMS. The effects of diet-induced weight loss (WL) and WL after Roux-en-Y gastric bypass (RYGB) surgery on β-cell function are unclear because of conflicting results from different studies, presumably because of differences in the methods used to measure β-cell function, the amount of WL between treatment groups, and baseline β-cell function. The goal of this study was to evaluate the…
Source: insight.jci.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
JCI Insight - Beta-cell function after Roux-en-Y gastric bypass surgery or reduced energy intake alone in people with obesity https://t.co/IvElXQpkN7
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Mashup Score: 12JCI Insight - Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans - 1 year(s) ago
Mice RiboTag (RRID:IMSR_JAX:011029; ref. 43), Chat-Cre (RRID:IMSR_JAX:006410; ref. 81), and Ai14 (herein referred to as tdTomato, RRID:IMSR_JAX:007914; ref. 82) mice were purchased from the Jackson Laboratory. C57BL/6 mice were obtained from the National Institute on Aging at the NIH. Hemizygous Chat-Cre mice were crossed with tdTomato mice to generate Chat-Cre;tdTomato mice, and with RiboTag…
Source: insight.jci.orgCategories: General Medicine News, Latest HeadlinesTweet-
Old #motorneurons don't die, scientists discover—they just slow down @BrownUniversity @JCI_Insight https://t.co/t2ZS6dK8tP https://t.co/Hj4dACdFLz
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Mashup Score: 4JCI Insight - Cytokine storm based mechanisms for extra-pulmonary manifestations of SARS-CoV-2 infection - 1 year(s) ago
ResearchIn-Press PreviewNephrology Open Access | 10.1172/jci.insight.166012 Ranjan Das,1 Joubert B. Kharlyngdoh,1 Eduardo Molina-Jijon,1 Hector Donoro-Blazquez,2 Stéphanie Gambut,2 Michael R. Crowley,3 David K. Crossman,4 Rasheed A. Gbadagesin,5 Sunveer S. Chugh,1 Sunjeet S. Chugh,1 Carmen Avila-Casado,6…
Source: insight.jci.orgCategories: General Medicine News, Latest HeadlinesTweet-
Research unveils paths to stopping #cytokine storms in COVID-19 @JCI_Insight https://t.co/Qy9Tro7mFl https://t.co/3feAOHuPoa
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Mashup Score: 1JCI Insight - Impaired PPARɣ activation by cadmium exacerbates infection-induced lung injury - 1 year(s) ago
ResearchIn-Press PreviewInfectious diseasePulmonology Open Access | 10.1172/jci.insight.166608 Shanrun Liu,2 Jennifer M. Pyles,3 Suzanne E. Lapi,3 Komal Saleem,1 Veena B. Antony,1 Manuel Lora Gonzalez,4 David K. Crossman,5 and A. Brent Carter1 1Department of Medicine, University of Alabama at Birmingham, Birmingham,…
Source: insight.jci.orgCategories: General Medicine News, Latest HeadlinesTweet-
How #cadmium-induced inflammation increases the severity and mortality of #lung infections @JCI_Insight https://t.co/1OsxriyypJ https://t.co/yqxYScTprC
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Mashup Score: 0JCI Insight - An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants - 1 year(s) ago
Research ArticleImmunologyTransplantation Free access | 10.1172/jci.insight.124732 Fuyi Liao,1 Davide Scozzi,1 Yuka Furuya,3 Kaitlyn N. Pugh,1 Ramsey Hachem,3 Delphine L. Chen,4 Marlene Cano,3 Jonathan M. Green,3,5 Alexander S. Krupnick,6 Daniel Kreisel,1,2 Anne Karina T. Perl,7,8 Howard J. Huang,9…
Source: insight.jci.orgCategories: Infectious Disease, Latest HeadlinesTweet-
Another innovative approach to CLAD prevention using 3T 🐁 🫁 model- adding CC10 can promote tolerance, driving club cell regeneration w ⬇️ IFNg, impacting T-RM cells and granzyme B expression - great promise for targeting therapies @WUSTLmed #ishlt2023 https://t.co/0aXlIhYQNY
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RT @anbu4genes: Very happy to share our new work out in @JCI_insight- https://t.co/MRUsZ2y7MI. This work was made possible by help and supp…