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    Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila - 2 year(s) ago

    Variants in TBC1D8B cause isolated nephrotic syndrome. TBC1D8B protein interacts with the slit diaphragm protein nephrin, but the pathogenesis remains unclear. We used Drosophila to elucidate the functional role of the recently discovered disease-causing gene. A null allele of Tbc1d8b in Drosophila exhibits a nephrocyte-restricted phenotype similar to patient presentation. Tbc1d8b protein…

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      JASN_News

      Variants in TBC1D8B cause isolated nephrotic syndrome. This study found variants in TBC1D8B are not infrequent among patients with FSGS. TBC1D8B, functioning in endosomal maturation and degradation, is essential for nephrin trafficking https://t.co/ppdJIAeWJZ @MartinHelmstdt1 https://t.co/IBTW1nUcTz

  • Mashup Score: 3
    Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome - 2 year(s) ago

    Rituximab is an established therapy in children with idiopathic nephrotic syndrome to sustain short to medium term disease remission and avoid steroid toxicities. Recent trials focus on its use as a first-line agent among those with milder disease severity. Rituximab is used in multi-drug refractory nephrotic syndrome and post-transplant disease recurrence, although the evidence is much less…

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      Rituximab is an established therapy in children with idiopathic nephrotic syndrome. This Review highlights recent advances on the use of rituximab for childhood nephrotic syndrome and how the therapeutic landscape is evolving https://t.co/mAQkDmLlFy @DrRulanParekh https://t.co/Yj91kXegoT

  • Mashup Score: 1
    Cost-Effectiveness of Dapagliflozin as a Treatment for Chronic Kidney Disease - 2 year(s) ago

    Background and objectives CKD imposes a significant burden on patients and health care providers, particularly upon reaching kidney failure when patients may require KRT. The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial demonstrated that dapagliflozin, with standard therapy, reduced CKD progression and KRT requirement. The study objective was to estimate the…

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      Dapagliflozin, a SGLT-2 inhibitor, was shown to be an efficacious treatment for CKD. This study estimates the cost-effectiveness of dapagliflozin for the treatment of CKD from payer perspectives in the UK, Germany, and Spain https://t.co/0BJGW8jDHd @DavidCWheeler2 https://t.co/GJMZRrEx01

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    Reproductive Healthcare is a Key Component of Comprehensive Care for Adolescents with CKD - 2 year(s) ago

    In order to get access to the article, you must have an account.  If you have an account, enter your user name and password into the boxes above. If you do not have an account, follow the instructions below to create one.  Once you have purchased the article, you will have access to it for 24 hours.   Steps for Creating an Account: Click the “Purchase Access” button.  The page will redisplay…

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      "It is our job as physicians to provide care that aligns with our patients’ goals. When missteps occur, we should do our best to help them get back on track." This article expresses the need for reproductive healthcare in adolescent patients with CKD https://t.co/BtiWJJbSAP https://t.co/NVJur5gehT

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    Management of Patients with Kidney Failure and Pericarditis - 2 year(s) ago

    Diseases of the pericardium, including pericarditis, pericardial effusion, and tamponade, are common in patients with kidney failure, but there are limited data to guide management. We present a clinical case and our approach to managing these challenging clinical situations. A 23-year-old woman

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      Diseases of the pericardium are common in patients with kidney failure. This Kidney Case Conference: How I Treat article presents a clinical case and an approach to managing these challenging clinical situations https://t.co/WYtzUvixkq https://t.co/6XORwJGzbQ

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    Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases - 2 year(s) ago

    Background: Fibroblast growth factor 23 (FGF-23) is associated with a range of cardiovascular and non-cardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding. Methods: SCALLOP consortium data on 19,195 participants were used to generate an FGF23 genetic score. Data…

    Source: American Society of Nephrology
    Categories: Latest Headlines, Nephrology
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      FGF-23 is linked to a range of diseases in conventional epidemiological studies. This study found that genetically predicted FGF-23 levels are not linked to atherosclerotic and non-atherosclervotic cardiovascular diseases https://t.co/CExUIvVi1r @willkidney @NatalieStaplin https://t.co/NbDr87iwPj

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    Genomic Disorders in CKD across the Lifespan - 2 year(s) ago

    Pathogenic structural genetic variants, also known as genomic disorders, have been associated with pediatric CKD. This study extends those results across the lifespan, with genomic disorders enriched in both pediatric and adult patients compared with controls. In the Chronic Renal Insufficiency Cohort study, genomic disorders were also associated with lower serum Mg, lower educational…

    Source: American Society of Nephrology
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      JASN_News

      Genomic disorders (GDs) are linked to many comorbid outcomes. Identification of GDs has diagnostic utility. This study found that undiagnosed GDs are detected both in children and adults with CKD https://t.co/6MbeVpiLXd @HaroldFeldman @kirylukk @ColumbiaKidney @ColumbiaMed https://t.co/APVbLSYLVu

  • Mashup Score: 2
    Reproductive Health in Women with Kidney Disease - 2 year(s) ago

    Menstrual abnormalities, including oligomenorrhea, polymenorrhea, and irregular menses, have adverse health effects and worsen the quality of life of women with kidney disease. Early menopause, defined as menopause before 45 years, leads to a decline in ovarian hormones, which is associated with a

    Source: American Society of Nephrology
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      "There remains a need to increase awareness regarding menstrual and reproductive health among patients and health care providers." This article discusses reproductive health in women with kidney disease https://t.co/g0o9BRKwKM @silvishah

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