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Mashup Score: 0A Microsimulation Study Of The Cost-Effectiveness of Hepatitis C Virus Screening Frequencies in Hemodialysis Centers - 1 year(s) ago
Background National guidelines recommend twice-yearly hepatitis C virus (HCV) screening for patients receiving in-center hemodialysis. However, studies examining the cost-effectiveness of HCV screening methods or frequencies are lacking. Methods We populated an HCV screening, treatment, and disease microsimulation model with a cohort representative of the US in-center hemodialysis population….
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 7
Background and objectives Menstrual abnormalities and shortened reproductive lifespan are associated with shorter life expectancy and higher cardiovascular and osteoporosis risk in the general population, although the magnitude of these reproductive factor irregularities in females with CKD is unclear. This systematic review and meta-analysis aimed to summarize the current knowledge regarding…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
This study shows that menstrual abnormalities & shorter reproductive lifespan are common in females with CKD, though kidney transplantation may improve menstrual health https://t.co/SnqfjQoEvF @DrSandiDumanski @SofiaAhmedMD @LibinInstitute @CalDomMed @UCalgaryMed @ICDC_Research https://t.co/XaXgug2vYj
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Mashup Score: 6
Background: Pruritus is a common symptom experienced by patients with nondialysis CKD, but risk factors for incident pruritus in this patient population have not been evaluated. Methods: We identified 1,951 participants with CKD in the Chronic Renal Insufficiency Cohort Study without pruritus at the baseline assessment. Pruritus was assessed by the Kidney Disease Quality of Life-36 instrument,…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
Pruritus is a common symptom experienced by patients with nondialysis CKD. This study found that a substantial proportion of patients with nondialysis CKD develop moderate-to-severe pruritus https://t.co/yLSg7reJqH @lesliemyint @DrTariqShafi @Macalester https://t.co/rTsPyX5vVD
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Mashup Score: 1
Background: Hepatocyte nuclear factor 1-beta (HNF1B) is an essential transcription factor during embryogenesis. Mutations in HNF1B are the most common monogenic causes of congenital cystic dysplastic renal malformations. The direct functional consequences of mutations in HNF1B on its transcriptional activity are unknown. Methods: Direct reprogramming of mouse fibroblasts to induced renal…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
Hepatocyte nuclear factor 1-beta (HNF1B) is an essential transcription factor during embryogenesis. This study provides insights into the renal transcriptional network that controls nephrogenesis https://t.co/gVZ90Sc8NU https://t.co/YtH9HRs96n
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Mashup Score: 0
Background. Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanics/Latinos, a population with high risk for metabolic disease. Methods. We used data from 3,736 participants from the Hispanic Community Health Study/Study of Latinos, of which 16% had diabetes and 9% had an…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
Albuminuria is linked to metabolic abnormalities. This study identified associations of albuminuria with metabolites involved in glucose dysregulation, and essential fatty acids and precursors of arachidonic acid in Hispanics/Latinos https://t.co/it8wTerPNz https://t.co/TQYGqvxS49
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Mashup Score: 0Activation of Stimulator of IFN Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases - 1 year(s) ago
A signaling molecule that plays a role in the innate immune system, stimulator of IFN genes (STING), is a crucial regulator of the cyclic GMP-AMP synthase (cGAS)-STING pathway. This signaling pathway regulates inflammation and energy homeostasis under conditions of obesity, kidney fibrosis, and AKI, but its exact role in the pathogenesis of glomerular diseases remains unclear. The authors found…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
A stimulator of IFN genes (STING), is a crucial regulator of the cyclic GMP-AMP synthase (cGAS)-STING pathway. This study shows that the activation of the STING pathway acts as a mediator of disease progression in DKD and Alport syndrome https://t.co/qntKR8jaIQ https://t.co/ZUtlJHl0dZ
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Mashup Score: 2
Structural racism embodies the many ways in which society fosters racial discrimination through “mutually reinforcing inequitable systems” that limit access to resources and opportunities that can promote health and well being among marginalized communities. To achieve health equity, and kidney health equity more specifically, structural racism must be eliminated. In February 2022, the National…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
To achieve health equity, and kidney health equity more specifically, structural racism must be eliminated. This article discusses the @NIDDKgov's “Designing Interventions that Address Structural Racism to Reduce Kidney Health Disparities” virtual workshop https://t.co/RKUGpRq1jm https://t.co/ZCuVyGUACS
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Mashup Score: 2The Immune System and Idiopathic Nephrotic Syndrome - 1 year(s) ago
Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome—and the drugs used to treat it—remain important causes of patient morbidity. Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, diseases that primarily affect the podocytes. In spite of decades of research, the underlying causes of both diseases remain…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, but the underlying causes of both diseases remain incompletely understood. This Review discusses the immunologic causes of idiopathic nephrotic syndrome https://t.co/lnD1MfOQYy @ruth_e_campbell
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Mashup Score: 8
Background and objectives For older patients with kidney failure, lowering symptom burden may be more important than prolonging life. Dialysis initiation may affect individual kidney failure–related symptoms differently, but the change in symptoms before and after start of dialysis has not been studied. Therefore, we investigated the course of total and individual symptom number and burden before…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
For older patients with kidney failure, lowering symptom burden may be more important than prolonging life. This study investigates the course of symptom number & burden before & after starting dialysis https://t.co/uff5bdOPeC @LUMC_Leiden @JBZDenBosch @fjcaskey @hoogeveen_ellen https://t.co/Iyb0fKrhXA
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Mashup Score: 0Sex Differences in Age-Related Loss of Kidney Function - 1 year(s) ago
Although more women than men have CKD, more men develop kidney failure. Sex or gender disparities in health status or access to health care, or sex-specific rates of kidney function decline, may explain sex or gender disparities in CKD epidemiology. In this study of a general northern European population, baseline kidney function (GFR measured by plasma iohexol clearance) was lower in middle-aged…
Source: American Society of NephrologyCategories: Latest Headlines, NephrologyTweet-
Sex differences in GFR loss https://t.co/53qR3RqDIq Higher vs Lower Arm BP & CV outcomes https://t.co/CwdCZF5A40
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National guidelines recommend twice-yearly hepatitis C virus (HCV) screening for patients receiving in-center hemodialysis. This study suggests that the KDIGO-recommended HCV screening interval is not a cost-effective use of health care resources https://t.co/skN0tXN64K https://t.co/OskRqR4Evs