Service
There are many dimensions to scientific life. We asked investigators about the impact of service to the scientific community and beyond and how service has shaped their experience, perspective, and research path.
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Functional differences between rodent and human PD-1 linked to evolutionary divergence
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
Antibody Response to RSV Vaccination in Immunocompromised Persons
This prospective study investigates antibody response following respiratory syncytial virus vaccination in immunocompromised individuals.
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
Gao et al. show that the plasma cells (PCs) can be recruited to glioblastoma stem cell (GSC) niches via the CCL2-CCR2 chemokine program and promote glioblastoma…
Photos: Kids celebrate the new year at noon in Iowa City
More than 350 on hand for balloon drop at Iowa City Public Library
Plasma cell and cancer stem cell crosstalk in glioblastoma
Plasma cells (PCs) are the main producers of antibodies and have context-dependent roles in tumor immunity. In this issue of Cancer Cell, Gao et al. report…
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
Gao et al. show that the plasma cells (PCs) can be recruited to glioblastoma stem cell (GSC) niches via the CCL2-CCR2 chemokine program and promote glioblastoma…
Evaluating rooftop PV’s impact on power supply-demand discrepancies in grid decarbonization
We investigate the feasibility of achieving a carbon-neutral grid by integrating rooftop PV systems and implementing energy storage to mitigate the mismatch between renewable generation…
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
Gao et al. show that the plasma cells (PCs) can be recruited to glioblastoma stem cell (GSC) niches via the CCL2-CCR2 chemokine program and promote glioblastoma…
Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer
Ge et al. show that cancer β-TrCP+ exosomes in the tumor microenvironment induce CD8+ T cell exhaustion in a YAP1-amino acid transport-mTORC1-dependent manner. Inhibiting cancer β-TrCP rescues…
Stem Cell Reports
This special issue is in partnership with the ISSCR Athens International Symposium “Neural Stem Cells: Capturing Complexity and Plasticity from the Cell to the Organism,”…